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Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms and demonstrating benefits to mouse neurons. Two of the most well-known components of marijuana are tetrahydrocannabinol, or THC, and cannabidiol, or CBD. They have the same atomic composition, but differ in structure. THC provides the high that is often associated with marijuana use. CBD, on the other hand, is considered benign and seems to possess antipsychotic, pro-cognitive, anti-inflammatory, anti-seizure, and antioxidant properties. In June 2018, the FDA approved Epidiolex, the first CBD-based prescription medication, for rare forms of epilepsy, and later for the treatment of some seizures. However, the research into both compounds is still in its infancy. In this new study, scientists dived deeper into the workings of CBD using C. elegans nematode worms, which is considered a good model for initial studies, including in geroscience. Previous research has shown that CBD can increase lifespan in C. elegans and zebrafish, but the mechanism had remained unknown. Another study found that CBD induces autophagy in cultured neuronal cells. In this new study, the researchers attempted to investigate the relationship between these two effects. Autophagy is the process of clearing away various cellular debris, such as misfolded proteins and dysfunctional organelles. Unsurprisingly, this maintenance system appears to be very important for health and longevity in numerous model organisms and in humans. The CBD treatment greatly increased autophagic activity in several tissues and cell types, most drastically by 78% in neurons. The researchers then validated those findings in vitro on several types of cells, including mouse primary hippocampal neurons. Importantly, impaired autophagy in the brain is considered a major cause of Alzheimer’s disease. Worms on CBD lived significantly longer than controls. The researchers also measured the worms’ healthspan. Many interventions that prolong lifespan in C. elegans often lead to functional impairment, such as decreased motility. Three popular health metrics in C. elegans that decline with age are pharyngeal pumping rate, reproductive capacity, and locomotion, and all three were significantly restored, rather than impaired, by CBD treatment. The gene SIRT1 has been a popular object of study in geroscience. One of its roles is a mediator of autophagy. By knocking out SIRT1 in mouse neurons, researchers were able to obliterate many of the benefits of CBD, pointing at a crucial role of SIRT1 in mediating CBD-induced effects. This study expands our understanding of CBD's effects, linking them to autophagy, an important process that keeps popping up on geroscientists' radars. It is encouraging that CBD demonstrates the strongest pro-autophagy effect in neurons, making it a potential anti-Alzheimer’s drug. Obviously, the fact that CBD increases autophagy in worms does not mean that using marijuana makes humans healthier, and we’ll need to see human trials on CBD and other compounds. SOURCES AND FURTHER READING ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity - https://pubmed.ncbi.nlm.nih.gov/35445360/ Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans - https://pubmed.ncbi.nlm.nih.gov/33998871/ Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205952/ Cannabidiol induces autophagy via ERK1/2 activation in neural cells - https://www.nature.com/articles/s41598-021-84879-2 EPIDIOLEX - https://youtu.be/zepKBzlKzdY FOOTAGE, IMAGES, AND MUSIC CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Stock footage & Images : Videoblocks.com, Shutterstock.com Music: "Elastic Vibe" by Ziv Moran PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Host, Producer, & Editor - Ryan O’Shea Writer - Arkadi Mazin Art - Mattijs Vonk, Tim Maupin Executive Producer - Keith Comito #CBD #Science #Longevity

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What is THC-P? And is it dangerous? If you’ve heard about THC-P (Tetrahydrocannabiphorol) — the newly discovered, ultra-potent cannabinoid — you’re not alone. It’s being marketed as 30x stronger than traditional THC, but what does that really mean for your body, mind, and safety? In this video, we break down everything you need to know about THC-P, including what it is, how it compares to Delta-9 THC, whether it’s legal, how it’s made, what risks it may pose, and whether it’s actually safe to consume. ⸻ 🧠 What You’ll Learn: • What is THC-P and how was it discovered? • How THC-P interacts with the body’s endocannabinoid system • Is THC-P really 30x more potent than Delta-9 THC? • What does a THC-P high feel like compared to other cannabinoids? • Is THC-P synthetic or natural? • Where is THC-P legal in the U.S. and globally? • Does THC-P show up on drug tests? • What are the side effects or dangers of using THC-P? • Is THC-P safe for beginners or should you avoid it? ⸻ ⚠️ Is THC-P Dangerous? While some sources claim THC-P is a natural cannabinoid, the way it’s extracted and concentrated for commercial use raises some safety questions. Because research is still in its early stages, there’s not much clinical data about THC-P’s effects — but users report intense highs, stronger than expected body effects, and sometimes anxiety or paranoia if dosed too high. If you’re considering trying THC-P, this video gives you all the facts to make an informed decision, especially if you’re new to high-potency cannabinoids. ⸻ 📌 Why This Video Matters: As cannabis products evolve, new cannabinoids like THC-P, HHC, THCA, and Delta-8 are popping up in vape cartridges, edibles, and tinctures — especially in dispensaries and smoke shops. But with loose regulations and limited studies, it’s crucial to understand what you’re consuming. We created this video to help cannabis consumers stay informed and avoid surprises when exploring powerful compounds like THC-P. ⸻ 👥 Who This Is For: • Cannabis consumers curious about rare cannabinoids • Dispensary shoppers wondering what’s in their carts • Medical marijuana patients evaluating new products • People researching the risks and benefits of THC-P • Anyone wondering if THC-P is legal, safe, and legit • Cannabis educators and influencers wanting clear info • New users who want to avoid a too-intense first experience ⸻ 📚 Watch Next: • THC vs THCA – What’s the Difference? • What Are Terpenes? – Full Breakdown of Cannabis Aroma Chemistry • Delta-8 vs Delta-9 vs THC-P – Potency Showdown • What To Expect Your First Time In a Dispensary • Are Cannabis Concentrates Too Strong for Beginners? ⸻ 🔍 Relevant SEO Keywords & Tags: THC-P explained, What is THC-P, is THC-P dangerous, THC-P vs THC, THC-P safety, strongest cannabinoid, new cannabinoids, THC-P side effects, THC-P review, THC-P risks, what is tetrahydrocannabiphorol, THC-P high, THC-P vs Delta-9, THC-P facts, cannabis science, cannabinoids explained, THC-P legal, rare cannabinoids, THC-P tinctures, THC-P vape safety, marijuana education, THC-P dose, THC-P for beginners ⸻ 📢 Stay Connected! 💬 Drop a comment if you’ve tried THC-P or are curious 👍 Like this video if you learned something new 🔔 Subscribe for weekly cannabis breakdowns 📤 Share this with your crew before they hit that vape cart ⸻ 🌿 Hashtags for Visibility: #THCP #CannabisEducation #Cannabinoids #WhatIsTHCP #THCPSideEffects #StrongestCannabinoid #CannabisScience #RareCannabinoids #WeedExplained #THCPHigh #CannabisContent #DispensaryTips #WeedTube #MarijuanaEducation #THCPDangerous

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Forget smoking marijuana or eating pot edibles, you won't even notice the newest way people are getting high. More and more are turning to a pot patch. Jaclyn Allen reports. ◂ The Denver Channel, 7News, brings you the latest trusted news and information for Denver, Colorado, Mile High and the Rocky Mountains. Our mission is to provide useful, interesting news and updates on breaking news to people in the Denver metro area, all across our beautiful state of Colorado and all over the world. For more download the 7News mobile app: iPhone: http://bit.ly/iOS-kmgh Android: http://bit.ly/kmgh-android

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Are you tired of living with chronic pain? Cannabis may be the natural remedy you've been searching for. In this video, we explore the benefits of cannabis therapy in managing chronic pain conditions. From reducing inflammation to promoting relaxation, we dive into the science behind how cannabis can be an effective tool in pain management. As a natural alternative to pharmaceuticals, cannabis has been shown to provide relief for patients suffering from a range of conditions. Join us as we discuss the miracle leaf and how it can be used to improve patient care and overall well-being. Whether you're looking for health tips or exploring medical marijuana as an option, this video is for you. Learn how cannabis therapy can be a game-changer for those seeking natural remedies for chronic pain relief.