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Carlat Psychiatry News | Stimulant Fraud • Oral Ketamine • E-Cigarettes • Benzo Tapering • CBD 💡Subscribe to our newsletter: https://www.thecarlatreport.com/products ➡️Check out our website: https://www.thecarlatreport.com/ ================ Follow Carlat: 🔴SUBSCRIBE ► / @thecarlatreport ➡️Twitter: / CarlatPsych ================ References: Hines, Lindsey A et al. “Incident psychotic experiences following self-reported use of high- potency cannabis: Results from a longitudinal cohort study.” Addiction (Abingdon, England) vol. 119,9 (2024): 1629-1634. doi:10.1111/add.16517 Fucito, Lisa M et al. “Varenicline for E-Cigarette Cessation in Adults: A Preliminary Placebo- Controlled Randomized Trial.” American journal of preventive medicine vol. 67,2 (2024): 296- 298. doi:10.1016/j.amepre.2024.04.007 Glue, Paul et al. “Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial.” Nature medicine vol. 30,7 (2024): 2004-2009. doi:10.1038/s41591-024-03063-x Gundugurti, Prasad Rao et al. “Evaluation of the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol oral solution (150 mg/mL) versus placebo in mild to moderate anxiety subjects: A double blind multicenter randomized clinical trial.” Asian journal of psychiatry vol. 97 (2024): 104073. doi:10.1016/j.ajp.2024.104073 Rohde, Christopher et al. “A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression.” The American journal of psychiatry vol. 181,7 (2024): 630-638. doi:10.1176/appi.ajp.20230477 Tuisku, Anna et al. “Electronic Cigarettes vs Varenicline for Smoking Cessation in Adults: A Randomized Clinical Trial.” JAMA internal medicine vol. 184,8 (2024): 915-921. doi:10.1001/jamainternmed.2024.1822 Benzodiazapene Tapering Guidelines: https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/guidelines/bzd-cpg-narrative-draft-for-public-comment.pdf?sfvrsn=6d96408_2 ================ 0:00 - Intro 0:29 DOJ Charges Telehealth Executives 1:55 Oral Extended Release Ketamine 3:29 MDMA Trials Suspended 04:43 Liquid Clonidine and Liquid Lithium 5:46 Benzodiazepine Tapering Guidelines 8:01 Antidepressants in Bipolar Disorder 10:52 Vaping Trials and Smoking Cessation 12:54 Brexpiprazole & Sertraline For PTSD 14:15 CBD Oil for Anxiety #MentalHealthNews #psychiatry #psychiatricmedications #psychnews #psychiatrynews #psychopharmacology #pmhnp #psychnp ================ In this episode, we explore nine groundbreaking stories in mental health and psychiatric medicine, covering everything from healthcare fraud to the latest advancements in drug trials. Healthcare Fraud Charges: The US DOJ has charged executives at Done, a California telehealth company, for allegedly prescribing 40 million Adderall pills without proper evaluation. Extended Release Oral Ketamine: New trials on an extended release oral ketamine show potential for treatment-resistant depression. (https://pubmed.ncbi.nlm.nih.gov/38914860/) MDMA-assisted Psychotherapy Setbacks: After FDA approval was pulled due to ethical concerns, can upcoming trials revive this promising therapy for PTSD? Liquid Formulations: Onyda is brand name for the new liquid Clonidine XR and the return of liquid lithium citrate offer new options for ADHD and bipolar patients. Benzodiazepine Tapering Guidelines: The American Society of Addiction Medicine's new draft guidelinesadvocate for a careful, patient-centric approach, especially for vulnerable populations. Antidepressants and Bipolar Disorder: A Danish study provides some reassurance about using antidepressants in bipolar disorder, but its methodology leaves some questions unanswered. E-Cigarettes vs. Chantix: A new trial finds nicotine e-cigarettes as effective as Chantix for smoking cessation, but flavored vape products and their health risks continue to spark debate. Brexpiprazole and Sertraline for PTSD: Brexpiprazole showing promise as an add-on treatment to sertraline, but will the FDA approve this new therapy? CBD Oil for Anxiety: A new phase 3 trial offers hope for treating anxiety with CBD oil, though its high cost rmay emain a barrier for many patients.

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