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Parkinson’s disease, also known as PD, is the second most common neurodegenerative disorder. The disease is characterized by a loss of dopamine-producing neurons in the substantia nigra, which is an area of the brain responsible for movement. Cannabis, specifically CBD, has shown promise in treating some of the symptoms of PD. In this video we will define Parkinson’s disease and cannabis, explain how cannabis can help with PD, and physician perspectives on prescribing cannabis.
This video was created by Demystifying Medicine students Simran Matharu, Mahek Minhas and Micaela McNulty in collaboration with the McMaster Demystifying Medicine Program
Copyright McMaster University 2021
For more information visit:
https://www150.statcan.gc.ca/n1/pub/82-003-x/2014011/article/14112-eng.htm
Time Stamps:
Introduction/What is Parkinson’s Disease? → 00:00 - 01:23
What is Cannabis? → 01:24 - 02:34
How Can Cannabis Help With Parkinson’s? → 02:35 - 05:09
Physician Perspectives → 05:10 - 07:19
Conclusion → 07:20 - 07:52
References:
Bega, D., Simuni, T., Okun, M. S., Chen, X., & Schmidt, P. (2016). Medicinal cannabis for Parkinson's disease: Practices, beliefs, and attitudes among providers at national Parkinson Foundation centers of excellence. Movement Disorders Clinical Practice, 4(1), 90-95.
Benner, E. J., Banerjee, R., Reynolds, A. D., Sherman, S., Pisarev, V. M., Tsiperson, V., Nemachek, C., Ciborowski, P., Przedborski, S., Mosley, R. L., & Gendelman, H. E. (2008). Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PloS one, 3(1), e1376.
Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009). The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology, 56, 235–243.
de Lau, L. M., & Breteler, M. M. (2006). Epidemiology of Parkinson’s disease. The Lancet Neurology, 5(6), 525–535.
Edelstein, O. E., Wacht, O., Isralowitz, R., Reznik, A., & Bachner, Y. G. (2020). Beliefs and attitudes of graduate gerontology students about medical marijuana use for Alzheimer’s and Parkinson’s disease. Complementary Therapies in Medicine, 52, 102418.
Gardiner, K. M., Singleton, J. A., Sheridan, J., Kyle, G. J., & Nissen, L. M. (2019). Health professional beliefs, knowledge, and concerns surrounding medicinal cannabis – A systematic review. PLOS ONE, 14(5), e0216556.
Hauser, R. A., Rascol, O., Korczyn, A. D., Jon Stoessl, A., Watts, R. L., Poewe, W., De Deyn, P. P., & Lang, A. E. (2007). Ten-year follow-up of Parkinson's disease patients randomized to initial therapy with ropinirole or levodopa. Movement disorders: official journal of the Movement Disorder Society, 22(16), 2409–2417.
Jankovic, J. (2008). Parkinson’s disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 79(4), 368–376.
Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L. E., Huang, X.-F., Liu, K., Arnold, J. C., & McGregor, I. S. (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443–457.
Lang, A. E., & Lozano, A. M. (1998). Parkinson’s Disease. New England Journal of Medicine, 339(16), 1130–1143.
Laun, A. S., & Song, Z. H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochemical and biophysical research communications, 490(1), 17–21.
Marras, C., Beck, J. C., Bower, J. H., Roberts, E., Ritz, B., Ross, G. W., Abbott, R. D., Savica, R., Van Den Eeden, S. K., Willis, A. W., & Tanner, C. (2018). Prevalence of Parkinson’s disease across North America. Npj Parkinson’s Disease, 4(1), 21.
Nutt J. G. (2000). Response to L-dopa in PD: the long and the short of it. Neurology, 54(10), 1884–1885. https://doi.org/10.1212/wnl.54.10.1884
Oeckl, P., Hengerer, B., & Ferger, B. (2014). G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology, 257, 1–9. https://doi.org/10.1016/j.expneurol.2014.04.010
Severe Spasticity. (2020). https://lioresal.com/severe-spasticity/.
Venderová, K., Růzicka, E., Vorísek, V., & Visnovský, P. (2004). Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms. Movement disorders: official journal of the Movement Disorder Society, 19(9), 1102–1106. https://doi.org/10.1002/mds.20111
Wang, M., Wang, Y.-H., Avula, B., Radwan, M. M., Wanas, A. S., Mehmedic, Z., van Antwerp, J., ElSohly, M. A., & Khan, I. A. (2017). Quantitative Determination of Cannabinoids in Cannabis and Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography and Diode Array/Mass Spectrometric Detection. Journal of Forensic Sciences, 62(3), 602–611. https://doi.org/10.1111/1556-4029.13341
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Super Deluxe deleted all of my old videos so I'm re-uploading here. Cheers! Composed, Performed and Edited by Nick Lutsko: Follow on Spotify: https://open.spotify.com/artist/0gEenHtJ9puwA63nbY2TAE Instagram: https://www.instagram.com/nicklutsko Twitter: https://twitter.com/NickLutsko Facebook: https://www.facebook.com/NickLutsko Bandcamp: http://nicklutsko.bandcamp.com/ Website: http://nicklutsko.com Graphic Design by Jesse Benjamin: http://jessebenjamin.com Produced by Jason Richards and Super Deluxe.
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In today's video, I try dabbing D8 for the first time. I try some shatter from Bay Smokes and see how it makes me feel. I hope you enjoy! In todays video, Check out my website at https://goblin420.com/ ! DISCLAIMER: I am in no way confessing to the acts stated in this video. This video, along with all others found on my channel, has been uploaded purely for entertainment purposes and should not be taken seriously. Contact: ☆Twitter☆ https://twitter.com/TheGoblinnn ☆Snapchat☆ thegxblin ☆Business E-Mail☆ [email protected] ☆Instagram☆ https://www.instagram.com/thegbln/ I hope you enjoyed, subscribe if you did!
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Royal King Seeds CBD & Chrome Pony Ranch: Week 8 Flower Power Explosion! Get ready for an electrifying update from the collaboration between Royal King Seeds and Chrome Pony Ranch as their strains hit the peak of their flowering stage in Week 8! This powerhouse partnership has been nurturing some of the most exceptional CBD and cannabis genetics, resulting in a true Flower Power Explosion. Here’s a closer look at the standout strains lighting up this grow: Royal King Seeds’ Stephen Hawking Kush and Ringo’s Gift, paired with Chrome Pony Ranch’s Hellraiser x Cherry Hash Breath. Each strain brings its own unique magic to this vibrant week of flowering. Royal King Seeds: CBD Excellence in Bloom Stephen Hawking Kush Inspired by the iconic physicist, Stephen Hawking Kush is a CBD-dominant strain designed for those seeking powerful relief with minimal psychoactive effects. Boasting a high CBD content and low THC, it’s a medicinal marvel. By Week 8, the plants are stunning—dense, resin-packed buds shimmer with trichomes, hinting at a robust cannabinoid profile. The scent is a calming mix of earthy pine and subtle citrus, offering a soothing experience that matches its therapeutic benefits. This strain is a shining star for wellness-focused users. Ringo’s Gift Named in honor of CBD pioneer Lawrence Ringo, this strain blends Harle-Tsu and ACDC genetics to deliver a balanced CBD-to-THC ratio. Known for its uplifting, clear-headed effects, Ringo’s Gift is perfect for daytime relief or maintaining focus. At Week 8, the plants are thriving, with lush green leaves and tight, compact buds releasing a sweet, herbal aroma that’s hard to resist. It’s a beautifully crafted strain that combines flavor, potency, and versatility. Chrome Pony Ranch: A THC-Charged Showstopper Hellraiser x Cherry Hash Breath Chrome Pony Ranch brings the heat with Hellraiser x Cherry Hash Breath, a THC-heavy hybrid that’s as bold as it is flavorful. Hellraiser delivers raw potency, while Cherry Hash Breath infuses a distinctive cherry sweetness layered with earthy, hashy notes. By Week 8, the buds are massive and sticky, coated in a thick blanket of trichomes that signal a knockout punch. The aroma is a heady mix of ripe cherries and deep hash, promising a euphoric, intense experience for those who dare to indulge. Week 8: A Burst of Flower Power At Week 8, the grow is a spectacle of cannabis at its finest. The plants are in peak form—trichomes gleam like jewels, buds swell with density, and vibrant colors signal a bountiful harvest on the horizon. Royal King Seeds’ Stephen Hawking Kush and Ringo’s Gift offer CBD-rich tranquility, while Chrome Pony Ranch’s Hellraiser x Cherry Hash Breath unleashes a THC-fueled thrill. Together, they create a perfect harmony of effects and flavors, catering to medical patients, recreational enthusiasts, and everyone in between. This Flower Power Explosion is a testament to expert cultivation and elite genetics. Stay tuned as Royal King Seeds and Chrome Pony Ranch prepare to harvest this extraordinary lineup—Week 8 is just the beginning of something truly spectacular!
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GABY Inc. (CSE: GABY OTCQB: GABLF) is a U.S. focused consumer packaged goods (CPG) company taking a unique approach to cannabis and hemp-infused products. With relationships in over 3,400 retailers in the mainstream sales channel, GABY bridges the gap between the licensed dispensary and mainstream markets. Success as a CPG company requires quality and speed. GABY has both; owning its manufacturing infrastructure and licenses, and thus controlling the quality of its products. GABY brands are ensured speed-to-market through its proprietary distribution infrastructure and licenses, its team of diverse salespeople, its network of third-party distributors, and its existing relationships with retailers. With a focus on its societal and environmental impacts, GABY is a conscious corporation striving to innovate and inspire through plant-based lifestyles. Learn more about GABY Inc. on their website: https://www.gabyinc.com/ If you want to learn more about the Market One Minute and how your company can reach millions of investors on BNN, please visit the Market One Minute section of our website here: http://bit.ly/2pBFSqP Missed an episode of a Market One Minute segment? Here’s a playlist to catch up on any you’ve missed: http://bit.ly/2D4PMqX » Subscribe to us on YouTube: http://bit.ly/2CYmf2y Engage with Market One » Like us on Facebook: https://www.facebook.com/marketonemediagroup/ » Follow us on Twitter: https://twitter.com/MarketOneMedia » Connect with us on LinkedIn: https://www.linkedin.com/company/market-one-media-group-inc- » Follow us on Instagram: https://www.instagram.com/marketonemediagroup/
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