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Obesity expert Dr Holly Lofton reviews three alternatives to GLP-1s to help patients drop excess weight. https://www.medscape.com/viewarticle/1000474?src=soc_yt -- TRANSCRIPT -- Hi. I'm Dr Holly Lofton. I'm a board-certified obesity medicine specialist, and I direct the medical weight management program at NYU Langone Health. There is so much information about glucagon-like peptide 1 (GLP-1) agonists as anti-obesity medications. I bet you can't think of a single person who hasn't heard of them, and many of your friends or family members may have even tried them. However, we also have what we call the first generation of medications for weight management, and I'll talk about some of those today. Phentermine. If your patient is not able to tolerate a GLP-1 agonist or is unable to access these medicines for various reasons, one option is phentermine, which has been around for decades. It is an oral medication that's usually taken once a day in the morning. It is a classic appetite suppressant. Phentermine makes people feel less hungry. It also gives people a little more energy, so they're able to increase their activity while creating a caloric deficit, and this leads to weight loss over time. Phentermine differs from the GLP-1 agonists, which are intended for chronic weight management. The FDA has approved phentermine for short-term weight loss; its use is recommended for no more than 12 weeks at a time. The medication comes in doses ranging from 8 mg to 37.5 mg and is usually slowly titrated up depending on tolerance and effect. Side effects that are most often reported include a racing heart, insomnia, agitation, and dry mouth. This drug is not for everyone. Phentermine is contraindicated in those with uncontrolled hypertension, with cardiac disease (such as a history of heart attack), or who are at high risk for heart attack or stroke. Some drug interactions can occur, which should be considered on a case-by-case basis. Phentermine may be an option for your patients if an elevated appetite is keeping them from losing weight. It should be used as an adjunct to lifestyle recommendations, which means eating fewer calories and increasing activity. Phentermine-Topiramate. Another non–GLP-1 agonist medication indicated for obesity is phentermine-topiramate [Qsymia]. This is another oral medication. The idea behind combining these two medications is that they can generate more appetite suppression without the high potential for side effects of phentermine alone, such as agitation, increased heart rate, or increased blood pressure. Topiramate is used for migraine or seizure prevention. One side effect of topiramate is unintentional weight loss, so they decided to combine phentermine with topiramate in one pill. Phentermine-topiramate comes in four different doses and is usually titrated up from the lowest to the highest dose. People who can't tolerate the higher doses of phentermine are able to tolerate Qsymia because the dose of phentermine is lower. This medication came to the market in 2012, after the SEQUEL trial, which demonstrated its safety and efficacy, achieved about 12% weight loss, which for many years was the highest weight loss seen with any other anti-obesity medications on the market. Because this is a combination medication, it has some potential side effects and contraindications. For example, we don't give phentermine-topiramate to people with uncontrolled hypertension or anxiety, and it is contraindicated in those with glaucoma. We don't give this medication to anyone who has had adverse reactions or hypersensitivity to either of the ingredients. Because the combination contains topiramate, it should not be prescribed to anyone with childbearing potential unless they are using an effective form of hormonal contraception or even two effective forms. Topiramate can increase the risk of having a baby with a cleft palate by five times if they become pregnant while taking this medication. Phentermine-topiramate is dosed once daily. One commonly reported side effect is paresthesia: numbness and tingling of the fingers and toes that can manifest as feeling very cold when it's cold outside. Although some patients report paresthesia, most say that it's not so intolerable that they want to discontinue the medication. There have been reports of vision changes in people taking phentermine-topiramate; if severe vision changes occur, it is recommended to discontinue the medication. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/1000474?src=soc_yt

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Summary and FAQ

In summary, Apple Keto Gummies are a delicious and effective weight loss solution that combines the power of apple cider vinegar and the keto diet. These gummies work by suppressing appetite, boosting metabolism, and increasing energy levels, making it easier for you to lose weight and keep it off. With natural ingredients and a proven formula, Apple Keto Gummies are a game-changer in the world of weight loss supplements.

FAQs:

1. Are Apple Keto Gummies safe to use?

Yes, Apple Keto Gummies are made with natural ingredients and are safe to use. However, it’s always a good idea to consult with your healthcare provider before starting any new supplement regimen.

2. How long does it take to see results with Apple Keto Gummies?10 Minutes A Day To Lose Weight For Woman

Results may vary, but many people start to see results within a few weeks of consistent use. For best results, it’s recommended to take Apple Keto Gummies as directed and follow a healthy diet and exercise routine.

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Yes, Apple Keto Gummies are gluten-free, dairy-free, and vegan, making them a great option for those with dietary restrictions. These gummies are also free from artificial colors, flavors, and preservatives.

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Are you looking for a way to lose weight and improve your health? Look no further than “Keto by Dr. Juan Rivera: A Doctor’s Prescription for Ketosis.” This groundbreaking book offers a comprehensive guide to the ketogenic diet, a high-fat, low-carb eating plan that has been shown to help with weight loss, reduce inflammation, improve brain function, and more. Written by Dr. Juan Rivera, a renowned physician and nutrition expert, this book is your roadmap to achieving ketosis and reaping the many benefits of this revolutionary diet.

Understanding Ketosis

First and foremost, “Keto by Dr. Juan Rivera” introduces readers to the concept of ketosis. Ketosis is a metabolic state in which your body burns fat for fuel instead of carbohydrates. By drastically reducing your carb intake and increasing your fat intake, you can transition your body into ketosis and start burning stored fat for energy. This process can lead to rapid weight loss, improved energy levels, and better mental clarity.

Dr. Juan Rivera explains how ketosis works, why it is beneficial for weight loss, and how to achieve and maintain ketosis through your diet. By following the guidelines laid out in this book, you can harness the power of ketosis to transform your body and improve your overall health.

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Final Thoughts

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How Is Weight Watchers Responding to the Semaglutide Competition? In this informative video, we’ll discuss the recent developments surrounding Weight Watchers and its strategies in response to the growing popularity of semaglutide medications for weight loss. With the weight management landscape evolving rapidly, Weight Watchers is taking steps to ensure it remains a key player in the industry. We’ll cover the expansion of their services, particularly regarding clinical support for members using glucagon-like peptide one medications. Additionally, we’ll touch on the company's recent financial restructuring efforts and what that means for its future. You’ll learn how Weight Watchers is maintaining its commitment to its members, partners, and vendors during this transition. This video aims to provide clarity on how these changes may impact your weight loss journey and what to expect moving forward. If you’re interested in understanding how established weight management programs are adapting to new medical solutions, this discussion is for you. Don’t forget to subscribe to our channel for more engaging content on health and wellness topics. ⬇️ Subscribe to our channel for more valuable insights. 🔗Subscribe: https://www.youtube.com/@TheHealthBrief/?sub_confirmation=1 #WeightWatchers #WeightLoss #Semaglutide #Ozempic #HealthManagement #GlucagonLikePeptide #WellnessJourney #ClinicalSupport #DietPlans #FinancialRestructuring #WeightLossJourney #HealthyLiving #Nutrition #FitnessGoals #HealthCare About Us: At The Health Brief, we are dedicated to making general medicine accessible and engaging for everyone. Our channel focuses on a wide range of topics, including common health concerns, medical advancements, and wellness tips. We aim to empower viewers with knowledge that can help them make informed decisions about their health and well-being. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.