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Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you’ll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help.  Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?

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http://losefatcells.blogspot.com - The best way to lose belly fat for most men and women may be easier than you think ... The best way to lose belly fat for most men and women may have nothing to do with what you eat, no matter how fast you want to lose it. It's true that a healthy diet plan and regular exercise both result in weight loss. But sometimes these two factors are just part of the solution, especially when it comes to getting rid of abdominal or visceral fat. Sometimes we have to check under the bonnet to see what the real problem is. As there are many reasons why men and women struggle to achieve a flat tummy, one needs to identify the probable cause(s) of unwanted weight gain. One of the most overlooked culprits that may interfere with reducing excess pounds, is a troubled digestive tract. The symptoms of an imbalanced digestive system aren't limited to weight gain, indigestion or a bloated stomach either. Associated problems can range from one extreme to the other, from IBS to diarrhea. As we age, our bodily systems don't function nearly as well as they once did. Up until we reach our 40s (and 50s when we experience middle-age spread), and beyond, losing weight is usually easier and quicker. Fortunately, there is a simple way to improve the way our bodies digest whatever we eat or drink efficiently, irrespective of how old we are. Natural substances such as enzymes, fiber and probiotics or prebiotics are required to break down proteins, carbohydrates, vitamins, and minerals into smaller units. This process enhances the absorption and distribution of nutrients, and facilitates the removal of waste products. While certain foods contain these natural elements, a more convenient way is to supplement the diet. A number of nutritional supplements can be taken that work together to aid digestion. Alternatively, you can take a unique digestive health supplement, which serves the same purpose. Proper digestion could be the best way to lose belly fat for some men and women, whether you're over 20 or over 60. If you feel this simple change could make a difference, then you may want to give it some serious thought. Once you start losing stomach fat, weight reduction usually follows in other fatty areas as well (hips, thighs, love handles, back etc). http://losefatcells.blogspot.com/2011/08/best-way-to-lose-belly-fat-for-men.html http://losefatcells.blogspot.com/

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In This video we will discuss how to manage issue of your hemorrhoids at home with the help of high fiber diet. Bawaseer ka ilaj DISCLAIMER Some contents are used for educational purposes under fair use.Copyright disclaimer under section 107 of the copyright act 1976,allowance is made for 'fair use' for purposes such as critism,comment,news reporting,teaching,scholarship and research.Fair use is a use permitted by copyright statue that might otherwise be infringing.Non-Profit,educational or personal use tips the balance in favour of fair use. My Most footage sources are www.pixabay.com www.pexels.com www.commons.wikimedia.org www.creativecommons.org www.flickr.com www.pxhere.com www.freeimageslive.co.uk About Me My Name Is Dr Afzal.I Graduated From Allama Iqbal Medical College Lahore. Based On Almost 20 Years Of My Experience In Field Of Medicine I Strongly Believe That If You Want A Healthy SocietyThen First & Foremost You Need To Educate & Inform People Living Around You About Their Basic Health Problems In The Easiest Possible Way.And In This Regard I Honestly Believe There Can Not Be A Plateform As Goid As Youtube Which Helps To Bring This Dream To Reality So Here I Present Myself With The Most Updated Medical Knowledge in Simplest Possible Way.But As I Always Say Its Just An Informative Video And It Can IN WAY be a substitute Of Your Primary Physician or Your Primary Doctor. So I Always always Request You To Please Consult Your Primary Health Care Provider In Case You Have any health Issue. THANKS Dr Muhammad Afzal

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Body recomposition, or "recomp," involves improving body composition by simultaneously decreasing fat and increasing muscle mass. Dr. Schoenfeld asserts that resistance training alone is a poor strategy for losing weight and is most valuable when used as an adjunct to calorie reduction. If a person reduces their caloric intake to lose weight, as much as 30 percent of their weight loss may come from muscle – unless they engage in resistance training. In this clip, Dr. Brad Schoenfeld describes the importance of resistance training and adequate protein intake to prevent losing muscle mass during weight loss. Interview published on Dec 6, 2022 Watch the full episode: https://youtu.be/SUy6HwOhT3U #exercise #protein #muscle

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