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Dr Tamaan K. Osbourne-Roberts reviews the list of patients who probably should not be taking GLP-1 receptor agonists. https://www.medscape.com/viewarticle/glp-1-ras-when-not-prescribe-2024a1000nd8?src=soc_yt -- TRANSCRIPT -- Hi. I'm Tamaan K. Osbourne-Roberts, family medicine physician and lifestyle medicine physician, here to discuss GLP-1 receptor agonist (RA) contraindications — the skinny on when not to prescribe. It can be hard not to think of GLP-1 RAs like Ozempic and Mounjaro as silver bullets, long-awaited miracle drugs that we should probably be putting in the water. And it's true they have the potential to help a lot of people. However, there are definitely groups of patients who should not take these drugs or should take them with caution. They include the following: Patients with a family history of certain cancers. Given that GLP-1 RAs can increase the risk for thyroid cancer, patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 should not take these drugs. Gut motility issues. Since one of the primary mechanisms of action for these drugs is to slow down the gut, patients with gastroparesis — diabetic or otherwise — or other gut motility issues should avoid these drugs. Patients with inflammatory bowel disease also should not use GLP-1 RAs. Pancreatitis. These medications can increase the risk for serious pancreatitis on their own, so use in patients who have had pancreatitis already is not recommended. Renal impairment. An eGFR [estimated glomerular filtrationrate] below threshold, typically around 30 mL/min/1.73 m2, excludes GLP-1 RAs for some patients. Be certain to check the threshold for individual medications before prescribing. And finally, pregnancy. These drugs generally should not be used in pregnancy, and people of childbearing age with the ability to become pregnant should use contraception while taking these medications. GLP-1 RAs are great medications and have the potential to revolutionize obesity medicine, but like all drugs, it's important to use them safely. Knowing when not to prescribe them is an important step in ensuring patient safety and will help ensure they are available for those who need them. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1-ras-when-not-prescribe-2024a1000nd8?src=soc_yt

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Semaglutide injection for weight loss has gained popularity in recent years as a promising treatment for obesity. This medication, originally developed for type 2 diabetes, has been found to have significant weight loss effects in clinical trials. As obesity rates continue to rise, finding effective and safe treatments for weight management is crucial. Semaglutide offers a new option for individuals struggling with obesity to help them achieve their weight loss goals.

How does Semaglutide Injection Work for Weight Loss?

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it works by mimicking the effects of GLP-1, a hormone that regulates appetite and food intake. By activating GLP-1 receptors in the brain, semaglutide helps to reduce feelings of hunger and increase feelings of fullness, leading to decreased food intake and ultimately weight loss.

In addition to its effects on appetite regulation, semaglutide also has metabolic benefits that contribute to weight loss. It helps to improve insulin sensitivity, reduce liver fat, and increase the body’s energy expenditure, all of which can help in the management of obesity.

Studies have shown that semaglutide injection can lead to significant weight loss in individuals with obesity. In one clinical trial, participants who received semaglutide lost an average of 15% of their body weight over 68 weeks, compared to 2.4% in the placebo group. This substantial weight loss can have important implications for overall health and reduce the risk of obesity-related complications.

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One of the key benefits of semaglutide injection for weight loss is its effectiveness in promoting significant and sustained weight loss. Unlike many other weight loss medications, semaglutide has been shown to lead to substantial weight loss that is maintained over time. This makes it a valuable tool for individuals looking to achieve long-term weight loss goals.





In addition to its weight loss effects, semaglutide also has other health benefits that can improve overall well-being. It can help to lower blood sugar levels, reduce blood pressure, and improve cholesterol levels, all of which are important factors in reducing the risk of heart disease and other obesity-related conditions.

Another advantage of semaglutide injection is its convenience and ease of use. The medication is administered once weekly via subcutaneous injection, making it a convenient option for individuals who may have difficulty adhering to daily medication regimens or frequent doctor visits.

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Like any medication, semaglutide injection can cause side effects in some individuals. The most common side effects reported in clinical trials include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild to moderate in severity and may improve over time as the body adjusts to the medication.

In rare cases, semaglutide injection may cause more serious side effects, such as pancreatitis or kidney problems. It is important to discuss any concerns or symptoms with your healthcare provider to determine the best course of action. It is also important to follow the prescribed dosing regimen and monitor for any potential side effects while taking semaglutide.

Overall, the benefits of semaglutide injection for weight loss outweigh the potential risks for many individuals with obesity. However, it is important to weigh the pros and cons and discuss any concerns with your healthcare provider before starting this medication.

Is Semaglutide Injection Right for You?

Deciding whether semaglutide injection is the right choice for weight loss depends on individual factors such as weight loss goals, medical history, and overall health. It is important to consult with a healthcare provider who can help determine the best treatment plan for your specific needs. Semaglutide injection may not be suitable for everyone, so a thorough evaluation is essential before starting this medication.

If you are struggling with obesity and have not had success with other weight loss methods, semaglutide injection may be a viable option to consider. Its proven effectiveness in promoting weight loss, along with its potential health benefits, make it a valuable tool in the fight against obesity. Discussing the pros and cons with your healthcare provider can help you make an informed decision about whether semaglutide is right for you.

Overall, semaglutide injection for weight loss offers a promising new approach to tackling obesity and improving overall health. With its ability to promote significant and sustained weight loss, along with its metabolic and health benefits, semaglutide may be a valuable addition to your weight loss journey. Consult with your healthcare provider to learn more about semaglutide injection and whether it may be the right choice for you.