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In an office in Bagsværd near Copenhagen, young biotechnologist Lotte Bjerre Knudsen has been made project manager for a promising, but uncertain project of converting the hormone GLP-1 into a drug that can prove effective in combating the rapidly growing wave of diseases such as type 2 diabetes in the 1990s. If she fails, the project will fold. Follow Episode 2 "If you don't fix this" of this advent calender from the Novo Nordisk Foundation "The Story of GLP-1". 00:00:00 - Introduction: Lotter Knudson's project on GLP-1 00:00:03 - The aim of converting GLP-1 into a drug 00:00:21 - The high stakes of the project 00:00:46 - Initial failed experiments with native GLP-1 00:01:14 - Innovative ideas for stabilizing GLP-1 00:01:50 - Use of fatty acids and albumin for protection 00:02:06 - Issues with purifying fatty acid-bound GLP-1 00:02:22 - A small crisis meeting and the biology-chemistry interplay 00:02:37 - Breakthroughs in understanding GLP-1’s biology 00:03:07 - The built-in safety switch of GLP-1 00:03:31 - Discoveries in Copenhagen on insulin and glucagon secretion 00:04:00 - Challenges in treating people with GLP-1 00:04:08 - Discovery of DPP-4 enzyme’s role 00:04:17 - Development of DPP-4 enzyme inhibitors 00:05:01 - Historical analogies with ACE inhibitors 00:05:47 - Development of DP4 inhibitors 00:06:18 - Long-acting GLP-1 analogs and their limitations 00:06:48 - Chemistry innovations to stabilize GLP-1 00:07:02 - John Eng’s discovery of Exendin-4 from Gila monster venom 00:08:02 - Challenges faced in patenting and developing Exendin-4 00:08:42 - Collaboration with Amylin Pharmaceuticals 00:09:53 - Management challenges and a deadline to fix the GLP-1 project 00:10:06 - Revisiting the initial solutions with new resources 00:10:48 - Issues in clinical trials and correct dosing 00:11:22 - Market competition and the first GLP-1 drug approval 00:12:00 - Investor skepticism and motivation to succeed

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Weight Loss Raspberry Pudding ❤️🎂👇🏻 45g of protein, no sugar, and fewer than 300 calories for this bagel. 🎉 💡 Sticking to your weight loss goals this year? We’re making it easier than ever with these hormone-balancing, GLP-1-boosting breakfasts—ready in just one minute, no meal prep needed! ❤️ Comment “QUICK” and we’ll DM you this new one minute recipe PLUS Week 1 of our 16-Week No-Prep Meal Plan to help you hit 100g protein/day consistently and stay motivated! 🔥 Our 16-Week Summer Countdown Meal Plan has begun! ✨ Comment “QUICK” and we’ll DM you Week 1 + this weight loss pudding recipe to kickstart your results! 📆 Come back next week to get Week 2! (Make sure you’re following so you don’t miss it!) These delicious recipes are made with Protein Milkshake, the world’s first all-natural GLP-1-boosting protein powder to help you achieve hormone balance and consistent weight loss! ✨ (Make sure you’re following, or I won’t be able to DM you!) #gethealthy #insulinresistance #guthealth #hormonalbalance #menopausalweightloss #balanceyourhormones #eatwell #healthyliving #weightlossover40 #healthyweightloss #healthyliving #weightlossjourney #weightlosstransformation #highproteinrecipes #lowcalorie #mealreplacement #breakfast #highprotein #mealprep #easyrecipes #mealplanideas #healthyrecipes

2 Understanding Glp1 For Weight Loss A Comprehensive Guide

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High Protein Mongolian Beef Noodles! All for 471 Calories🍜🔥 One of the tastiest combos, the beef is so tender snd goes perfectly with the noodles. Packed with flavour and lots of protein making this perfect for weight loss and meal prep for the week ahead! Macros per serving (4 total) 471 Calories | 48g Protein | 48g Carbs | 9g Fat Ingredients (4 servings) - 700g Lean Beef Steak cut into thin strips (i use Topside beef, get it straight from a butchers) - 20-30ml Light Soy Sauce - 2 tsp Garlic Powder - 2 tsp Black Pepper - 1/2 tsp Baking Soda (use this to make the beef extra tender!) - 2-3 tsp Olive Oil - 20g Cornflour/Cornstarch (used to make it crispy but is optional) - 220g Uncooked Egg Noodles (Brand: Asia’s Specialty from Aldi) - Green Onion/Scallion (the white and green parts used separately) - 4-5 Garlic Cloves Chopped - 1/2 Red Onion Sliced For the Sauce - 40ml Dark & Light Soy Sauce (20ml each) - 50g Oyster Sauce (Brand: M&S) - 40ml Water - 5-10g Cornflour/Cornstarch Mixed with 15ml water - Garnish with Chilli Flakes & Sesame Seeds Find more Easy & Delicious Recipes Like this in my Digital Cookbook!👨‍🍳📖❤️ Important Cooking Notes - Marinate the beef for 30mins to allow the baking soda to tenderise it - Use cooking spray on the pan when cooking the beef, 2-3 mins will be sufficient as you don’t want to over cook the beef - When making the sauce, let it come to a bubble before adding the cornflour slurry. Then let it thicken for 2-3 mins before adding the beef back in - Cook your noodles following the packet instructions. I cooked mine for 5-6 mins in boiling water on a very low heat . . . . . #noodles #beef #beefnoodles #steak #mealprep #healthyrecipes #highprotein #easyrecipes #lowcalorie #lowcaloriemeals #quickmeals #takeout #takeaway #gymfood #foodie #fitness #weightloss #fatloss