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I show guys a full day of eating and discuss what is important for preventing muscle loss while cutting and losing fat. ONLINE COACHING: [email protected] STUDIES IN VIDEO --------------- Caloric Deficit Study - https://www.ncbi.nlm.nih.gov/pubmed/21558571?dopt=Abstract Optimal Protein Intake Study - https://jissn.biomedcentral.com/articles/10.1186/1550-2783-11-20 Training Intensity & Volume Reference - http://www.bodyrecomposition.com/training/weight-training-for-fat-loss-part-2.html/ Calorie Cycling Study - https://www.ncbi.nlm.nih.gov/pubmed/21410865

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Resources for the Community ___________________________________________________________________ https://linktr.ee/theplussidezpodcast Ro - Telehealth for GLP1 weight management https://ro.co/weight-loss/?utm_source=plussidez&utm_medium=partnership&utm_campaign=comms_yt&utm_content=45497&utm_term=55 Find Your US Representatives https://www.usa.gov/elected-officials United States Patent & Trademark Office Website and Email https://www.uspto.gov/ [email protected] i-MAK Website https://www.i-mak.org/ i-MAK Briefs & Reports https://www.i-mak.org/resource-type/briefs/ ______________________________________________________________________ Tahir Amin, founder of I-MAK, joins us to break down why GLP-1 meds like Ozempic and Mounjaro stay so pricey. We dig into evergreening, patent thickets, and how pharma companies use legal loopholes to delay generics and extend monopolies. We also explore why some companies spend more on stock buybacks than drug innovation—and what that means for access. If you’ve felt exploited by the system, you’re not alone. But there’s hope. Learn about the policy changes ahead and how you can take action to fight for affordable meds. Tahir Amin bio: Tahir Amin is a founder and CEO of the Initiative for Medicines, Access & Knowledge (I-MAK), a nonprofit organisation working to address the systemic inequities in how medicines are developed and distributed. He has over 30 years of experience in intellectual property (IP) law, during which he has practised with two of the leading IP law firms in the United Kingdom and served as IP Counsel for multinational corporations. His work focuses on changing the structural power dynamics that allow health and economic inequities to persist by challenging and re-shaping IP laws and the related global political economy to better serve the public interest. He is a former Harvard Medical School Fellow in the Department of Global Health & Social Medicine and has served as legal advisor/consultant to many international groups, including the European Patent Office and World Health Organization, as well as testifying before the U.S. Congress on intellectual property and unsustainable drug prices. Special Guest Co-Host, Amanda Bonello from GLP-1 Collective https://glp1collective.org/ ______________________________________________________________________ Join this channel to get access to perks: / @theplussidez ______________________________________________________________________ #Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide #GLP1 #Obesity #zepbound #wegovy

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Key Points Question Are glucagon-like peptide-1 receptor agonists semaglutide and liraglutide, which were originally introduced for the treatment of type 2 diabetes and are frequently prescribed due to their weight loss properties, associated with disproportionately increased reporting of suicidality? Findings This disproportionality analysis through the case-control design based on the World Health Organization global database collecting suspected adverse drug reactions, identified a disproportionality signal of suicidal ideation with semaglutide, which remained significant when comparing semaglutide with dapagliflozin and metformin and in the subgroup of patients with coreported use of antidepressants and benzodiazepines. Meaning A detected signal of semaglutide-associated suicidal ideation warrants urgent clarification. Abstract Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained use primarily due to their weight-reduction effects, although a regulatory review was undertaken for potential suicidality concern. Objectives To evaluate potential signals for suicidal and self-injurious adverse drug reactions (ADRs) associated with the GLP-1 RAs semaglutide and liraglutide. Design, Setting, and Participants Disproportionality analysis through the case-control design using the World Health Organization (WHO) global database of suspected ADRs. Participants were clinical patients worldwide experiencing an ADR suspectedly attributable to semaglutide or liraglutide in the database from inception to August 30, 2023. Data were analyzed from September to December 2023. Exposure Treatment with semaglutide or liraglutide regardless of indication or treatment duration. Main Outcomes and Measures Reporting odds ratio (ROR) and the bayesian information component (IC) with 95% CIs were calculated as measures of disproportionate reporting of suicidal and self-injurious ADRs associated with semaglutide and liraglutide compared with all other medications. Sensitivity analyses were conducted including patients with coreported use of antidepressants and benzodiazepines and using dapagliflozin, metformin, and orlistat as comparators. A disproportionality signal was considered when the lower limits of the ROR and IC were above 1 and 0, respectively. Results A total of 107 (median [IQR] age 48 [40-56] years; 59 female patients [55%]) and 162 (median [IQR] age 47 [38-60] years; 100 female patients [61%]) cases of suicidal and/or self-injurious ADRs were reported between November 2000 and August 2023 with semaglutide and liraglutide, respectively. Significant disproportionality was detected only for semaglutide-associated suicidal ideation (ROR, 1.45; 95% CI, 1.18-1.77; IC, 0.53; 95% CI, 0.19-0.78), which remained significant in patients with coreported use of antidepressants (ROR, 4.45; 95% CI, 2.52-7.86; IC, 1.96; 95% CI, 0.98-2.63) and benzodiazepines (ROR, 4.07; 95% CI, 1.69-9.82; IC, 1.67; 95% CI, 0.11-2.65), when compared with dapagliflozin (ROR, 5.56; 95% CI, 3.23-9.60; IC, 0.70; 95% CI, 0.36-0.95), metformin (ROR, 3.86; 95% CI, 2.91-5.12; IC, 1.20; 95% CI, 0.94-1.53) and orlistat (ROR, 4.24; 95% CI, 2.69-6.69; IC, 0.70; 95% CI, 0.36-0.95). Conclusions and Relevance This study using the WHO database found a signal of semaglutide-associated suicidal ideation, which warrants urgent clarification.