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Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today we’re diving into a topic that’s been everywhere lately: GLP-1 medications like semaglutide and tirzepatide for weight loss. You may know them by names like Wegovy, Ozempic, Mounjaro, or Zepbound. I want to give you a clear, realistic picture of what to expect—because while the media loves to highlight the dramatic before-and-after photos, the real journey can be slower and more nuanced for some. So in this episode, we’re going to talk about the truth—what these medications can do, what they can’t, how long things really take, and what you need to know to set yourself up for success. Not hype, not magic promises—just real, honest insight to help you understand the process. Let’s get into it. How GLP-1 & GIP/GLP-1 Agonists Work So first things first—how do these meds work? Semaglutide is a GLP-1 receptor agonist, and tirzepatide is a dual GIP and GLP-1 receptor agonist. Basically, they mimic natural hormones in your body that help regulate blood sugar, slow digestion, and—most importantly for weight loss—reduce appetite and improve satiety. That means you feel fuller faster and stay full longer. You're not obsessing over food like before. And that’s powerful. But—and this is a big one— these peptides don't magically erase years of weight gain overnight. What they do is help make weight loss easier by reducing hunger and supporting your metabolism—but they don't do all the work for you. It’s important to remember they're a powerful tool, not a replacement for your efforts. You're still in control of your choices, habits, and long-term success. Why We Titrate the Dose—and What "Therapeutic Dose" Means Now, let’s talk about dosing. When you start Wegovy, you don’t start at the highest dose. It’s gradually increased over several weeks to give your body time to adjust and to help reduce side effects like nausea or stomach upset. The usual schedule looks like this: You’ll start with 0.25 mg once a week for the first month. Then it increases every four weeks—0.5 mg, then 1 mg, then 1.7 mg. By week 17, most people reach the full dose of 2.4 mg once a week—that’s the dose shown in studies to lead to the most consistent weight loss, with many people losing around 15% of their total body weight over about a year. But here’s the thing—not everyone follows this path exactly, and that’s okay. Some people need to slow down or stay longer at a lower dose if they’re having side effects. Others may need to increase sooner if they’re not seeing appetite changes and are tolerating the medication well. And even though 2.4 mg is considered the “therapeutic dose,” not everyone needs to reach it. Some people feel great and lose weight at a lower dose—and if that’s you, that’s your sweet spot. The real goal is to find the lowest effective dose that controls your hunger, helps you lose weight at a steady pace, and keeps side effects to a minimum. This isn’t a one-size-fits-all journey, and pushing through side effects just to hit the max dose isn’t necessary—or safe. Your best dose is the one your body handles well and helps you make progress. *How Much Weight Can You Expect to Lose—and How Fast? Let’s take a look at the clinical studies. In large trials, people on semaglutide lost about 15% of their total body weight over 68 weeks. For tirzepatide, it was even higher—20% or more in some cases. But here’s the thing—those results happened over a year to a year and a half. Not 6 weeks. Not 3 months. It’s a marathon, not a sprint. Also, most of the weight loss doesn't happen during the titration phase. You may see some weight loss early on, especially if your appetite plummets. But the bulk of the weight loss happens once you reach and maintain your therapeutic dose. Why Everyone’s Journey Looks Different I can’t stress this enough—everybody’s journey is different. Some people feel zero hunger from their very first injection. Others don’t notice a big change until week 10 or 12. Some drop 10 pounds in the first month. Others lose two pounds and feel discouraged. All of those experiences are normal. Your age, hormones, medications, stress levels, sleep, and past diet history? They all play a role. And let’s be real—gaining 20, 50, or 100 pounds didn’t happen in a few weeks, right? It likely took months or even years of lifestyle habits, hormonal shifts, emotional eating, or underlying conditions. So we have to give ourselves that same grace and patience when we’re trying to take the weight off—even with medical support. Navigating Side...

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-84lb weight loss on Mounjaro! Tough week on Mounjaro and experienced some issues that I did not see coming. I will discuss what I did wrong on my weight loss journey and how it increased my Mounjaro side effects. #mounjaro #zepbound #tirzepatide My Mounjaro/Zepbound Amazon Necessities Travel Case: https://amzn.to/3WYwfnm Best Deoderant: https://amzn.to/4aVy6Nj Ninja Creami: https://amzn.to/4dXohAZ Favorite Smoothie Blender: https://amzn.to/4bXRVEl Handheld Frother: https://amzn.to/4bDBdKD Smart Body Scale: https://amzn.to/4bILs0A Food Scale: https://amzn.to/3VjbQbg Control Underarm Sweat: https://amzn.to/4aA0IeI Motive Pure Electrolytes: https://amzn.to/3KqI2mM Grass Fed Organic Whey Protein: https://amzn.to/4dS3vTg Favorite Protein Bars: YUM https://amzn.to/3V3VfXX Mini Beef Sticks: https://amzn.to/3WWLVHT Gin Gin Ginger Chews: https://amzn.to/4dW8PVH Collagen Peptides: https://amzn.to/3WPOtHK Hair Towel Wrap: https://amzn.to/3QT62Tk Hair Brush: Boar Bristle: https://amzn.to/4bJC9gg Hair Brush: https://amzn.to/3wKC3WO Silk Pillowcase: Primary: https://amzn.to/3yvrGXD Travel: https://amzn.to/4boqxQ0 Innersense: https://amzn.to/4c5cqzh Travel Case: https://amzn.to/3WYwfnm *Not medical advice, talk to your own healthcare provider.

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Ozempic isn’t making you healthy. It’s making your body think you’re in a famine. You’re not just losing fat—you’re losing muscle. You’re losing bone. “We’re medicalizing thinness and selling starvation,” says Dr. Raj Patel. Women are reporting hair loss, missed periods, brittle bones, and gallstones. One study found 40% of the weight lost isn’t fat. It’s your body breaking itself down just to stay thin. And here’s the kicker: Once you stop? 67% of the weight comes back within a year. So ask yourself: Are you losing weight—or losing your health? 👉 Full episode Related Video Link #uncomfortable #rxansmith #politics #ozempic #zepbound

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American College of Cardiology now recommends GLP1 medications first line for weight loss! What are your thoughts? #glp1 #Ozempic #Mounjaro #heartdisease #medicine #wellness #health #greenscreen

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Are GLP-1 Medications Reshaping Healthcare Costs? Are they just moving the costs around? Are GLP-1 medications replacing gastric bypass surgeries? Cardiac Bypass? Can they put an end of type 2 diabetes? Why won't insurance be for such a cost savings medication? Grab your water, and let's dive in. 💬 Let’s Connect: Facebook page: 👉https://www.facebook.com/GLP1journeyinreview Instagram: 👉https://www.instagram.com/lorrieissman Subscribe to YouTube channel: 👉https://www.youtube.com/@Glp1journeyinreview Subscribe for More: Follow GLP 1 Journey in Review for healthy recipes, weight loss tips, and personal insights into life on GLP-1 medications. #glp1medication #weightlossjourney #healthyliving #weightmanagement #glp1journeyinreview #zepbound #ozempic #glp1 #semaglutide #healthcare #insuracecoverageApple Cider Vinegar Gummies Review They Work