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Today we’ll talk about a question I get asked a lot. Is it safe to take metformin with semaglutide? The short answer: It depends. But before we dive into how taking metformin and semaglutide together may affect you, I’d like to go over why someone might be prescribed both semaglutide and metformin. Semaglutide (Ozempic) and metformin are prescribed to help people with type 2 diabetes manage their blood sugar. However, semaglutide (Wegovy) can also help people manage their weight, especially when used in addition to healthy lifestyle changes like diet, regular exercise, and stress management. Metformin is also prescribed to help treat some symptoms of polycystic ovary syndrome (PCOS), like insulin resistance, irregular menstrual cycles, obesity, and increased hair growth. Can I take metformin and semaglutide together for weight loss? The short answer is yes. In fact, when prescribed together, the medications help manage blood sugar levels. Type 2 diabetes, obesity, and PCOS have been linked to insulin resistance. In this condition, the body doesn’t respond appropriately to insulin, leading to high blood sugar and weight gain. Semaglutide stimulates insulin secretion from the pancreas to lower blood sugar and reduce appetite; metformin improves insulin sensitivity. There’s no interaction between metformin and semaglutide. Both medications are considered safe when taken as instructed. Still, it’s important to remember that taking semaglutide with blood-sugar-lowering medications like metformin can raise the risk of low blood sugar (hypoglycemia). If you have type 2 diabetes and you’ve been prescribed metformin to help manage your blood sugar, it’s important to regularly check your blood sugar levels to help avoid low blood sugar. Your healthcare provider may also suggest that you have an emergency glucagon product or carry glucose tablets to raise your blood sugar quickly if severe low blood sugar happens. Signs of low blood sugar include feeling shaky, having a fast heartbeat, sweating, confusion, dizziness, or feeling hungry. They may also lower your metformin dose to decrease your risk of low blood sugar. Although rare, low blood sugar can happen if you take semaglutide alone. But this typically doesn’t happen because semaglutide tells your body to release insulin in response to food. What about side effects? When taken together, the side effects are typically the same as those experienced when taking the medications on their own. We’ve discussed the common side effects of semaglutide before, but I’d like to review them again. The common side effects of semaglutide are stomach-related (nausea, vomiting, diarrhea, constipation, burping, and bloating) and usually occur with dose increases and go away with time. And some people experience headaches and fatigue. Similar to semaglutide, most people experience stomach-related side effects like diarrhea, nausea, vomiting, and gas. What about alcohol use? A couple of weeks ago, we discussed how the occasional alcoholic beverage is okay with semaglutide. But it’s important to remember that you may be at risk for pancreatitis and kidney problems with long-term, heavy alcohol use. This risk is higher for dehydrated people due to fluid loss from side effects like nausea, vomiting, or diarrhea. Like semaglutide, heavy alcohol use should be avoided while taking metformin as it can increase the risk of developing a condition called lactic acidosis. Lactic acidosis is when too much lactic acid is in our blood, and our organs cannot function properly. This is considered a medical emergency. Symptoms of lactic acidosis include trouble breathing, stomach pain, and muscle aches. Oddly enough, you may have heard that semaglutide can may alcohol less appealing for people taking it. In other words, you may not even want to drink alcohol while taking semaglutide. This is likely because when you drink alcohol, a chemical called dopamine is released. Typically, dopamine makes you feel good. But when you take semaglutide, glucagon-like peptide-1 (GLP-1) agonist targets areas in the brain that block the dopamine boost. Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! Pro Tips We’re huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness? Giving yourself a peptide injection can be scary or confusing. But we’ve got you covered. Check out 6 tips to make peptide injections easier

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Discover the truth behind weight loss drugs like Ozempic, Wegovy, Mounjaro, and Zepbound. Dr. Jack Mosley, GLP-1 expert, shares insights on their effectiveness, risks, and the importance of smart nutrition. Learn about his book 'Food Noise' and how to navigate the complex landscape of weight management. #weightlossdrugs #smartnutrition #GLP1

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Discover how to actually burn belly fat while sleeping in bed. Increasing your metabolism is possible for anyone regardless of your age and these tips will help boost your resting metabolic rate fast. Find out how to burn fat while sitting, sleeping, and resting. 🔥 FREE 6 Week Shred: http://bit.ly/2Bv8CL4 📲 FREE Diet/Workout Planner Tool: http://bit.ly/2N41lTX If you could burn more belly fat while sleeping in a bed it would make getting and staying lean significantly easier. As human beings, we spend about a third of our entire lives sleeping and even though it might sound too good to be true it's actually very possible to burn significantly more fat at rest than you're burning right now, That's why in today's video, I'm going to give you 8 proven ways that you can speed up fat burning while asleep.  First, although it won't be a huge increase one of the easiest ways to bump up your metabolism and burn more calories while sleeping is to have a Casein shake 30 minutes before bed.(1) Not only do studies show that casein is absorbed perfectly fine while you sleep but digesting it positively affects your resting metabolic rate throughout the night and even into the next morning (2). Since Casein has a slow digestion rate it provides a continuous release of amino acids into your bloodstream while you sleep. This can help maintain muscle protein synthesis throughout the night as well, which prevents muscle breakdown and assists with muscle recovery. Another big benefit of, having casein before bed is that it can help you feel full for longer. This can help reduce nighttime snacking or overeating before going to sleep. As a trainer, it's very common to hear that many people struggle with late-night cravings and often mindlessly eat hundreds upon hundreds of calories right before bed. Having a filling casein shake or an alternative casein source like cottage cheese, or Greek yogurt, can effectively reduce appetite at night and can lower overall calorie intake. Taking casein before bed consistently over time has also been proven to benefit muscle strength and muscle growth. (3)  And that's actually one of the best ways to burn more belly and body fat while sleeping... by building more muscle. Muscle tissue is metabolically active and significantly more metabolically active than fat: This is because it requires energy to maintain itself. It also requires energy to carry out essential functions like repairing broken-down muscle fibers, supporting posture, and producing movement. This constant energy expenditure contributes to a higher resting metabolic rate, which means anytime that you're at rest regardless of whether you sleeping or relaxing on a couch you'll be burning more calories per minute, per hour, and per day, than you would if you had less muscle on your body. While fat tissue does of course cost some calories to maintain, it's less metabolically active compared to muscle. The other benefit of muscle tissue is that it's able to absorb and store glycogen which is the broken down and stored version of carbohydrates. Every time you lift heavy weights you'll deplete a lot of the stored glycogen in your liver and muscle tissue, allowing you to refill those glycogen stores again, without them spilling over into fat storage.  That actually brings us to the next thing you can do to burn more calories while sleeping lift heavy weights or perform other high-intensity workouts. This is due to something known as the Afterburn Effect, which is often used as a gimmicky term in fitness marketing campaigns to sell magic fat-burning pills, at-home exercise equipment, and training programs. But the afterburn effect is actually a real science-based phenomenon. The exact mechanism that supports a faster metabolism after high-intensity exercise is known as Excess Post-Exercise Oxygen consumption or in short Epoc. Essentially epoc leads to an increased amount of calories continuing to be burnt even after being done training. Your body will continue to burn calories at an elevated rate after a weightlifting session because it needs to repair and recover muscle tissue, replenish energy stores, and remove waste products. This increased post-exercise calorie burn, can last anywhere from a few hours up to 2 whole days after performing your last set. How long it lasts for you depends on things like the intensity and duration of your weight training session. Higher intensities create a longer-lasting afterburn. It also depends on your fitness level, if you're well-conditioned epoc will actually be shorter-lived than if you're out of shape because your body will be able to bounce back faster. Lastly, compound movements like squats, deadlifts, and bench presses typically create a greater afterburn than isolation movements like bicep curls and tricep extensions. As an added benefit resistance training in general can improve insulin sensitivity, which helps your body better manage blood sugar levels, and can positively...

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