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There are no quick solutions or magical pills that easily solve the problems of obesity. But new anti-obesity drugs are proving remarkably effective, cutting body weight by an average 15% to 22%. Medicines including Ozempic and Wegovy could trigger a shift in how doctors treat obesity. We hear from some people taking them and William Brangham speaks with Dr. Fatima Cody Stanford about the drugs. Stream your PBS favorites with the PBS app: https://to.pbs.org/2Jb8twG Find more from PBS NewsHour at https://www.pbs.org/newshour Subscribe to our YouTube channel: https://bit.ly/2HfsCD6 Follow us: Facebook: http://www.pbs.org/newshour Twitter: http://www.twitter.com/newshour Instagram: http://www.instagram.com/newshour Subscribe: PBS NewsHour podcasts: https://www.pbs.org/newshour/podcasts Newsletters: https://www.pbs.org/newshour/subscribe

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A diet drug that has generated some news is the French drug called "Acomplia Rimonabant." The anti-obesity drug, an appetite suppressant, was created to help people lose fat by blocking circuitry in the brain that gives the body cravings. The drug works by an entirely new approach by blocking the same primeval circuitry in the brain that gives pot-smokers the munchies. The French firm Sanofi-Synthelabo won approval to market it in the European Union in 2006. It is not yet approved in the U.S., where it is known as "Zimulti". A study found that the drug helped people drop 20 pounds in a year. Doctors say the drug is noteworthy because it takes a different approach to helping people overcome their cravings for food. It is the first of a class of medicines that blocks the so-called endocannabinoid system in the central nervous system. Marijuana makes people hungry by stimulating this circuitry. The same biology serves crucial everyday purposes by helping the brain regulate hunger, including alcohol craving. Overeating can overstimulate this system, which in turn causes people to eat and smoke more. By temporarily blocking the body's ability to receive these signals, experts believe they can return the system to normal. In the larger of the two studies, Dr. Jean-Pierre Despres of Laval University in Quebec City used 1,036 volunteers, all with stomachs that put them at high risk for heart problems. They were urged to cut 600 calories/day and given either accomplia or placebos. After a year, those who got the higher of two doses of accomplia had lost an average of 20 pounds and trimmed three inches from their waists. Nearly half of them took off 10 percent of their body weight. By comparison, those on placebos lost just five pounds. Those receiving accomplia improved in other ways, as well: their levels of good cholesterol rose 23 percent, while their triglycerides fell 15 percent. **We will beat any competitors price GUARANTEED YourTramadol.com**

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Learn how to build muscle fast. Even if you're a skinny guy or hardgainer you can gain weight and bulk up if you just follow this diet and workout advice. The link to create you're own bulking meal plan is below and by sticking to your macros you'll gain healthy weight while building muscle mass. 🔥 FREE 6 Week Shred: https://GravityTransformation.com 📲 Fat Loss Calculator: http://bit.ly/gt-calculator27 Timestamps: #1 Not Eating Enough Calories 1:07 #2 Increase Your Carbs 4:02 #3 Progressive Overload 5:20 #4 Undulating Periodization 7:09 #5 Eat Enough Protein 7:55 #6 Don’t Overdo Cardio 9:17 #7 Get Enough Sleep 10:46 If you consider yourself a hardgainer and you find that no matter how hard you try, you just can't pack on any more muscle you're probably wondering, "what am I doing wrong here?" You've probably spent months, or maybe even years trying to bulk up but you're still skinny, you don't have much noticeable muscle mass, and most of your t shirts are still baggy, especially around your arms. Meanwhile you see other people that just seem to have an easier time than you. People that might not workout as much or they might eat the worst foods, yet they seem to be able to build muscle just by looking at a dumbbell. This can become really frustrating and even if you're a persistant person that doesn't quit, it can be very easy to simply label yourself as a hardgainer and to start making excuses. But the truth is that you're not a hardgainer. That's right....you heard me.. you're not. Sure everyone's biology and physiology is different, and sure you may have a slightly tougher time building muscle than others, but most of what you believe about being a hardgainer is just a myth that's keeping you skinny. In reality, if you just do the 7 things that I"m about to show you consistently, I don't care how much of a hardgainer you think you are, you're going to bulk up. The first and most common problem for... Research: 1. "consumption of amino acids, in particular leucine, stimulating increased muscle protein synthesis via the mTOR signaling pathway" Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514292/ 2. "long-term severe CR reduces serum total and free testosterone" https://www.ncbi.nlm.nih.gov/pubmed/20096034 "Restricting calories increased the total output of cortisol" https://www.ncbi.nlm.nih.gov/pubmed/20368473 3. Extreme calorie surpluses provide no muscle-building benefit but do cause fat gain. See figure 1 of the study https://www.ncbi.nlm.nih.gov/pubmed/23679146 4. Bench press strength associated with chest size: See figure 1 https://www.ncbi.nlm.nih.gov/pubmed/24169471 5. "more successful powerlifters typically have higher degrees of muscle mass expressed per unit height and/or bone mass" https://www.ncbi.nlm.nih.gov/pubmed/25611080 "the significant differences were for muscle mass and muscular girths, it would appear likely that these differences contributed to the stronger lifters' superior performance." https://www.ncbi.nlm.nih.gov/pubmed/17786689 https://www.ncbi.nlm.nih.gov/pubmed/19826300 6. Ideal protein intake is 1.6g/kg or about 0.8g/lb See Figure 5 https://bjsm.bmj.com/content/52/6/376 7. "greater protein intakes and a more even distribution across meals are modifiable factors associated with higher muscle mass" Link: https://www.ncbi.nlm.nih.gov/pubmed/27465379 "an even distribution of daily protein intake across meals is independently associated with greater muscle strength" Link: https://www.ncbi.nlm.nih.gov/pubmed/28515070 8. “a balanced distribution of daily protein intake" "acutely stimulated the synthesis of muscle contractile proteins more effectively than a skewed distribution" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420900/ 9. Concurrent training: The negative effect that cardio has on lower body strength/muscle mass See Figure 1 https://www.ncbi.nlm.nih.gov/pubmed/22002517 10. "resulting in an increase in AMPK activity after endurance exercise" & "AMPK"... "leads to the inactivation of mTOR and a decrease in the rate of protein synthesis" https://www.ncbi.nlm.nih.gov/pubmed/17095927 (10.5) 2% Carbs vs 77% carbs effect on Muscles https://www.ncbi.nlm.nih.gov/pubmed/15879168 (11) Testosterone to Cortisol Ratio 60% carbs vs 30% carbs https://www.ncbi.nlm.nih.gov/pubmed/20091182 (12) "The carbohydrate restriction program caused a significant reduction in the number of squat repetitions performed" https://espace.library.uq.edu.au/view/UQ:142963 (13) "Approximately 1 hr of SR on five nights a week led to less proportion of fat mass loss" "despite similar weight loss" https://www.ncbi.nlm.nih.gov/pubmed/29438540 (14) high-GI meal resulted in a significant shortening of SOL in healthy sleepers https://www.ncbi.nlm.nih.gov/pubmed/17284739

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