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In this episode of "In the Interim..." we revisit the ground-breaking seamless phase 2/3 clinical trial for the GLP-1 agonist, dulaglutide—better known as Trulicity. We discuss the intricacies of the adaptive trial design, and the unique features that helped expedite development by 12-18 months. Listeners will gain insight into how Bayesian algorithms and innovative statistical methods were pivotal in navigating a complex trial design, benefiting Eli Lilly's pipeline and changing the landscape of diabetes treatment. Key Highlights: —Outline of the trial design and the barriers faced during its inception in 2007-2008. —Explanation of the Clinical Utility Index and its role in adaptive randomization. —The DSMB's role and interaction with Bayesian decision-making models. —Simulation-based design to optimize development efficiencies. —Insights into the predictive power of the trial on weight loss outcomes in subsequent trials. Quotes: —"The trial was run entirely by Bayesian algorithms." – Scott Berry —"They believed this utility function was absolutely the right way to go forward." – Scott Berry For more head to berryconsultants.com.

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To support our channel and level up your health, check out: Our Fast Weight Loss Course: http://thehealthnerds.com/the-science-of-fast-weight-loss-course Our Better Health Basics Course: http://thehealthnerds.com/food-health-happiness Recommended Supplements from Video: Fish Oil: https://amzn.to/3GC92vx Vitamin D: https://amzn.to/3GCON0F Protein Powder: https://amzn.to/3HBnbdv Matcha Green Tea: https://amzn.to/3rBHWA8 Apple Cider Vinegar: https://amzn.to/3oBpHZR Probiotics: http://amzn.to/2iUbkeV Today we are going to talk about 8 weight loss supplements that actually work. Also, when talking about supplements for weight loss, there's a lot of contradictory and scammy information out there! But before that, here are 3 scams to watch out for: 1. Watch out for Celebrity Endorsement. 2. Watch Out for Anything Hyped Out of Its Mind. 3. Finally, Watch Out for Proprietary Blends. This is a common way for supplement producers to mask the amounts of quality ingredients in a supplement and use a lot of filler ingredients instead. Ok, here are the 8 Weight Loss Supplements That Actually Work 1. Water Before you start looking for expensive supplements and pills, make sure to get the basics right. Getting in 100oz of water a day will have a bigger weight loss impact than most realize. Water not only boosts one’s metabolism, but it also will keep you full making it easier to fight off those pesky sugar cravings. 2. Caffeine Caffeine is a well-known metabolism booster and is a common ingredient in commercial weight loss supplements. Its most powerful effects come from the fact that it boosts the metabolism and can increase fat burning by up to 29%. You can get more caffeine in by drinking coffee or taking a caffeine pill. 3. Fish Oil While taking more “omega 3 fatty acids” doesn’t scream "weight loss", the enzymes they produce can help initiate the fat-burning process. More importantly, omega-3s are one of the most well-researched and documented supplements of all time. They have been proven to help with blood flow, lowering triglyceride levels, reduce the effects of depression, and have many other benefits. Improving your overall health by supplementing with fish oil will help your body function more efficiently, which will help you lose weight! 4. Vitamin D Known as the sunshine hormone, an estimated 85% of people in the US are deficient in vitamin D. This is probably due to the increase in technology and fewer outdoor activities people are participating in these days. And similar to fish oil, it’s one of the best supplements you can take. It lowers the risk of certain cancers Improves cognitive function in the elderly Lowers the amount of fat mass on the body Lowers blood pressure Improves balance Studies suggest that if you increase your levels of Vitamin D when starting a low-calorie diet, you’ll lose more weight, including in that stubborn belly region. 5. Protein Powder Protein helps improve metabolism, combat cravings, and reduce the loss of muscle when dieting. Keep protein powder on the go when you need a healthy meal, but there are no good options available. 6. Matcha Green Tea Powder Green tea is a popular dietary supplement for weight loss because of the antioxidant EGCG, which can boost your metabolism during exercise. It comes in a powder form as opposed to loose or bagged tea leaves. Drink 2-4 cups daily for best effects. 7. Apple Cider Vinegar ACV is a powerful health and weight loss supplement proven to help: Curb appetite Improve skin health Increases insulin sensitivity Get better nutrient absorption for your food And more Mix with 8oz of water for best effects! And now for the weight loss supplement people miss... 8. Probiotics Probiotics are live microorganisms found in the gut that help process the food we eat. In fact, during a 3-month study, women taking the probiotics lost 50% more weight compared to the group taking a dummy pill (placebo). They also continued to lose weight during the weight maintenance phase of the study. The point is, your gut health matters and taking care of it with a healthy probiotic can really work wonders. Those are the supplements for weight loss and the 8 best weight loss supplements that actually work! Studies used: http://ajpendo.physiology.org/content/268/6/E1192.short http://ajcn.nutrition.org/content/49/1/44.long http://www.ncbi.nlm.nih.gov/pubmed/18006026 http://jn.nutrition.org/content/139/2/264.full http://jcem.endojournals.org/content/92/8/3334.full http://www.ncbi.nlm.nih.gov/pubmed/20847729 http://www.ncbi.nlm.nih.gov/pubmed/24299712 http://www.ncbi.nlm.nih.gov/pubmed/16015276 The Health Nerd is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com.

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Are you struggling to lose weight and looking for a natural solution that actually works? Look no further than A1 Keto BHB, the groundbreaking weight loss supplement that has taken the world by storm. Featured on the popular television show Shark Tank, A1 Keto BHB has gained massive popularity for its ability to help people shed excess pounds and achieve their dream body. In this article, we will explore the incredible results of A1 Keto BHB on Shark Tank and how it can help you achieve your weight loss goals.

Revolutionary Weight Loss Supplement

A1 Keto BHB is a revolutionary weight loss supplement that is designed to help people burn fat and lose weight quickly and effectively. The key ingredient in A1 Keto BHB is beta-hydroxybutyrate (BHB), which is a ketone that the body produces during ketosis. By taking A1 Keto BHB, you can increase the levels of BHB in your body, which helps your body enter ketosis faster and burn fat for energy instead of carbs. This results in rapid weight loss and improved energy levels.

Unlike other weight loss supplements on the market, A1 Keto BHB is all-natural and free from harmful chemicals and additives. This means that you can trust that you are putting a safe and effective product into your body. A1 Keto BHB is also easy to take, with convenient capsules that can be taken with water or any beverage. With consistent use of A1 Keto BHB, you can see significant results in just a few weeks.

One of the reasons why A1 Keto BHB has gained so much attention is its appearance on Shark Tank, the hit television show where entrepreneurs pitch their products to a panel of investors. The founders of A1 Keto BHB were able to secure a deal with one of the Sharks, who saw the potential of this incredible weight loss supplement. Since then, A1 Keto BHB has become a household name and a go-to solution for people looking to lose weight and improve their health.

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Countless men and women have experienced life-changing results with A1 Keto BHB. By following a healthy diet and exercise routine while taking A1 Keto BHB, many people have been able to shed pounds and achieve a leaner, more toned physique. Customers rave about the energy boost they get from taking A1 Keto BHB, as well as the improved mental clarity and focus that comes with being in ketosis.

One customer, Lisa, shared her success story with A1 Keto BHB, saying, “I have struggled with my weight for years, trying every diet and exercise plan out there with little to no results. But with A1 Keto BHB, I finally found something that works for me. I have lost 20 pounds in just two months and feel better than ever. I can’t recommend A1 Keto BHB enough!”Carbofire Ignite Your Weight Loss Journey With The Ultimate Fat Burner

If you are ready to take control of your weight and transform your body, A1 Keto BHB is the solution you have been searching for. With its proven track record of success and natural ingredients, A1 Keto BHB can help you reach your weight loss goals and live a healthier, happier life. Don’t wait any longer – try A1 Keto BHB today and see the results for yourself!

Frequently Asked Questions

Q: Is A1 Keto BHB safe to take?

A: Yes, A1 Keto BHB is made with all-natural ingredients and is free from harmful chemicals and additives. It is safe to take and has been shown to be effective for weight loss.

Q: How quickly will I see results with A1 Keto BHB?

A: Results may vary, but many customers see significant weight loss results within a few weeks of consistent use of A1 Keto BHB. By following a healthy diet and exercise routine, you can maximize your results.

Q: Can I take A1 Keto BHB if I have medical conditions or take medications?

A: It is always recommended to consult with your healthcare provider before starting any new supplement regimen, including A1 Keto BHB. Your healthcare provider can advise you on whether A1 Keto BHB is safe for you to take based on your individual health profile.

Q: Do I need to follow a specific diet or exercise plan while taking A1 Keto BHB?

A: While A1 Keto BHB can help boost your weight loss efforts, it is important to follow a healthy diet and exercise routine to maximize your results. A balanced diet and regular exercise can help you achieve your weight loss goals more quickly.

Q: Can I purchase A1 Keto BHB in stores?

A: A1 Keto BHB is available for purchase online through the official website. This ensures that you are getting a genuine product and can take advantage of any discounts or promotions that may be available. Visit the official website today to order your supply of A1 Keto BHB and start your weight loss journey!

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