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https://bengreenfieldfitness.com/dom A few months ago, I recorded a highly controversial ketosis interview with Dr. Richard Veech, in which Dr. Veech claimed that the form of ketones most people take to get into ketosis are actually quite dangerous. Dr. Veech's solution was something called "ketone esters", which are extremely expensive, but, according to him, a far more natural, safe and healthy way to quickly get the body into ketosis - for anything from managing medical conditions, to improving cognition, to increasing endurance and beyond. In the video below, I actually experimented with these spendy ketone esters myself and, as you can see, the results were astounding... After shooting this video, I took another bottle of ketone esters to a Tough Mudder event and recorded a crazy video on Snapchat during which I elevated both blood glucose by drinking 75 grams of pure glucose and elevated blood ketones by drinking a bottle of the ketone salts, and the results were equally as astounding, resulting in one of the fastest races of my life. But the question remains: are these fancy, expensive ketone esters actually far better than ketone salts? Are ketone salts, which is what most people use, actually going to result in long term health issues? In today's podcast, I bring on ketosis expert Dr. Dominic D’Agostino to get his opinion. Dominic is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, cancer inflammation and performance enhancement in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. He's also no stranger to this podcast, having been a previous guest in the episode "A Deep Dive Into Ketosis: How Navy Seals, Extreme Athletes & Busy Executives Can Enhance Physical and Mental Performance With The Secret Weapon of Ketone Fuel". During today's discussion, you'll discover: -The difference between a ketone salt and a ketone ester...[9:25] -Three unique compounds you can "mix" with ketones to enhance deliverability, and the important difference between BCAAs and EAA's...[23:55] -Why is it that some people, including Dr. Veech, believe ketone esters to be dangerous and MCT oil to block BHB absorption...[41:05 & 62:40] -What Dominic has found by testing both ketone salts and ketone esters in his lab...[44:30] -If there is actually any evidence of people experiencing medical issues with the use of ketone salts or esters...[47:50] -The safety of using ephedrine for fat loss, and Dom's own experience with ephedrine...[60:05] -Whether you can combine glucose with ketones to enhance performance...[65:40] -Why the salts so much more expensive than the ester, and whether there are ways to make either that actually are cost effective...[72:15] -And much more! Resources from this episode: -My article and review of common ketone supplements such as Pruvit and KetoCaNa called "How To Get Into Ketosis" -The Metabolic Therapeutics Conference -NatureAminos amino acids supplement -Brain Octane -The HMB/ATP stack that Ben takes (and the study that discusses this approach) -Is It Possible To Be Extremely Active and Eat A Low Carbohydrate Diet? (my interview with Peter Attia) Do you have questions, thoughts or feedback for Dominic or me? Leave your comments at https://bengreenfieldfitness.com/dom and one of us will reply!

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In this first segment, we look at how effective GLP-1 treatments are. Two standout medications are Semaglutide (known as Ozempic and Wegovy) and Tirzepatide (or Mounjaro). At the highest dose, Semaglutide helps people lose an average of 15% of their total body weight, while Tirzepatide has shown even more impressive results with a loss of 21% of total body weight. Both are promising options for those looking to manage their weight. Next, we'll talk about how to take GLP-1 medications. Most of these drugs, like Ozempic, Wegovy, and Mounjaro, are given as weekly shots. This means fewer doses, making it simpler for patients. But there's also a pill version of Semaglutide called Rybelsus, which is taken daily. This is great for those who prefer pills over injections. When starting GLP-1 medications for weight management, patients usually begin with the lowest dose. Initially, the weight loss progress is checked every month. For patients losing a pound or more each week, they stick with that dose. For patients losing weight more slowly, the dose would typically be increased. Once the right dose is found, it can be continued for the long term and the dose no longer needs to be adjusted monthly. And the good news? There's typically no need for routine lab tests before starting the medication. Now, we'll talk about who qualifies for GLP-1 medications. These drugs, first made for type 2 diabetes, are now used for weight loss. If your BMI is 30 or above, you qualify based on BMI alone. If your BMI is 27 or higher you can also qualify if you have a weight related condition such as high blood pressure, diabetes, prediabetes, or high cholesterol. Lastly, those who have diabetes can qualify for a GLP-1 as a treatment for diabetes. At this point, we'll talk about who might not be a good fit for these medications. They're not recommended for people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Those with stomach issues like gastroparesis or a history of pancreatitis should also be cautious. Always chat with your doctor to see if these drugs are safe for you. Let's talk about possible side effects. GLP-1 medications can sometimes lead to digestive issues like nausea, vomiting, or diarrhea, and you might feel tired or fatigued too. These side effects are usually strongest after your first dose or when the dose goes up. The good news is they typically only last about a day and go away on their own. That's why we often suggest taking the medicine on a Saturday so you can rest at home and not deal with discomfort at work. When using GLP-1 medications, it's important to be aware of potential interactions with other drugs. If you're also taking diabetes medications like insulin or sulfonylureas, there's a risk of low blood sugar, so close monitoring is essential. Additionally, GLP-1s might affect the absorption of certain drugs, like birth control pills, potentially reducing their effectiveness. Let's discuss the costs. GLP-1 medications like Semaglutide (Ozempic, Wegovy, or Rybelsus) and Tirzepatide (Mounjaro) can be expensive, sometimes more than $1,000 per month. The good news is that insurance, especially private insurance, often covers most of the cost. To get insurance coverage, your doctor will need to submit a prior authorization to your health insurance company, usually after sending your prescription to the pharmacy. The insurance approval process typically takes about one week but can sometimes take longer, up to a few weeks. If you're looking for more affordable options, compounding pharmacies offer custom versions that are often a few hundred dollars per month, shipping included. To find the best option for your budget, talk to your doctor and insurance company. As a side note, another potential issue regarding the accessibility of these medications is that they are extremely popular and are sometimes sold out at pharmacies due to high demand. Research shows that sustaining weight loss through diet and exercise alone without the help of medication is tough. Studies show that most dieters gain back most of the weight they lost within two years. But, using GLP-1 medications like Ozempic, Wegovy, or Mounjaro offers a different story. Those who continue to take their GLP-1 medication tend to maintain their weight loss and avoid regaining the pounds. GLP-1 medications provide a helpful tool to break the cycle of yo-yo dieting seen with the usual weight loss methods that use diet and exercise changes alone. This is why it is usually recommended to take GLP-1 medications long term to maintain the benefits. If you stop taking them, your weight is likely to go back up to where it was before starting the medications. So, it's important to see GLP-1 medications as part of a long-term plan, not a quick fix.

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💉 Thinking about microdosing Ozempic or other GLP-1 medications like semaglutide and tirzepatide? Here’s a clear, math-based guide to using pen clicks to calculate your exact microdose! 📊 ⚠️ Important: Microdosing Ozempic is NOT FDA-approved and NOT recommended by Novo Nordisk. This guide is for educational purposes only. Always consult your healthcare provider. 🚨 In this video you’ll learn: ✔ Why more people are microdosing GLP-1 medications. ✔ How to calculate Ozempic microdoses using pen clicks. ✔ Step-by-step formula for 0.25mg, 0.5mg, 1mg, and 2mg Ozempic pens. ✔ Real-world click counts reported by users. ✔ Critical warnings about pen differences and safety tips! 🧮 Simple Math Breakdown: ➔ Confirm your pen's labeled dose. ➔ Manually count full-dose clicks. ➔ Divide full dose by clicks = dose per click. ➔ Calculate your microdose using the clicks! 💬 Ready to feel more confident managing your Ozempic pen? Let’s dive in! 👉 Watch next: "Why Ozempic Doses Feel So Different Between People" ➔ Tap the playlist at the end! 🎥==================. https://www.youtube.com/playlist?list=PLEXh8W6bLS3Pg0mlJsDYEUJ11HiXK3g0K ----------------------------------------------------------------- #ozempicclicks #OzempicClickschart #OzempicMicrodosing #GLP1 #Semaglutide #Tirzepatide #PharmacistExplains #DoctorExplains #DiabetesTreatment #WeightLossJourney #HealthTips #OzempicPen #OzempicTips #Microdosing #OzempicGuide ------------------------------------------------------------------ Disclaimer – Fair Use Our videos do not negatively impact the original works. The content we create is for informational and educational purposes only. We use only the audio component and small portions of video footage when necessary. DISCLAIMER: Copyright Disclaimer under Section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education, and research. Fair use is a legally permitted use under copyright law that might otherwise be infringing.