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Investigation on the Effects of GLP1 analog and SGLT2 inhibitor against Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms Background: The present study investigated the possible cardioprotective effects of GLP1 and SGLT2i against diabetic cardiomyopathy (DCM) in type 2 diabetic rats and the possible underlying mechanisms. DCM is defined as the presence of heart failure in absence of coronary artery disease. Methods: Thirty-two male Sprague Dawley rats were randomly subdivided into 4 equal groups; a) control group, b) DM group, type 2 diabetic rats with saline daily for 4 weeks, c) DM+ GLP1, as DM group with GLP1 analogue (liraglutide) at a dose of 75 µg/kg for 4 weeks, and d) DM+ SGLT2i: as DM group with SGLT2 inhibitor (dapagliflozin) at a dose of 1mg/kg for 4 weeks. By the end of treatment (4 weeks), serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB) were measured. Also, the cardiac histopathology, myocardial oxidative stress markers (MDA, GSH and CAT) and norepinephrine (NE), myocardial fibrosis, the expression of caspase-3, TGF-, TNF- and tyrosine hydroxylase (TH) in myocardial tissues were measured. Results: T2DM caused significant increase in serum glucose, HOMA-IR, serum CK-MB and LDH (p less than 0.05). Also, DM caused significant myocardial damage and fibrosis, elevation of myocardial MDA, NE with upregulation of myocardial caspase-3, TNF-, TGF- and TH and significant decrease in serum insulin and myocardial GSH and CAT (p less than 0.05). Administration of either GLP1 analog and SGLT2i caused in significant improvement in all studied parameters (p less than 0.05). Conclusion: We concluded that either of GLP1 and SGLT2i exhibited cardioprotective effects against DCM in T2DM with the upper hand for SGLT2i. This might be due to attenuation of fibrosis, oxidative stress, apoptosis (caspase-3), sympathetic nerve activity and inflammatory cytokines (TNF- and TGF-). #type #2 #cardiomyopathy #oxidative #stress #3 #glp1 #norepinephrine #tgf #tnf #and #tyrosine

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We’re in Week 4 of the “Get Less Fat” transformation and Week 2 of the Summer Sizzle Challenge and this one might be my favorite video yet. Why? Because there's a little competition. We launched a mini challenge inside Fitness Culture this week: 30-20-10 of wall balls and rowing If you’re a Fitness Culture member and you beat my time (4:48), you get a $50 gift card. If you don’t… well, you still get a killer workout. Let’s see what you’ve got. In this video: ✅ Weigh-in update (still 253… but body comp is changing) ✅ Full Summer Sizzle Week 2 Lower Body Workout ✅ Zombie squats, reverse lunges, hip work, and glute ham raises ✅ The full Metcon breakdown + leaderboard call-out ✅ Tips on tempo, mobility, and how to approach each movement Whether you’re in the challenge or just starting your comeback, this one will push you. 📲 Enrollment for the official challenge is closed, but you can still follow the entire program inside the Fitness Culture App. Jump in, follow the weekly workouts, and climb the leaderboard with us. — 💬 Comment below if you beat my time 📉 Goal: 235 lbs and a new performance phase 📅 Subscribe for weekly check-ins, transformation content, and raw training footage #VanillaGorillaChallenge #SummerSizzle #FitnessCulture #JakeHutton #MetconChallenge #WallBalls #RowerWorkout #TransformationSeries #WeightLossJourney #100vs1 Timecodes: 0:00 - Intro 0:08 - Weekly Check in 0:35 - Today' s Workout 0:48 - Active Warm-up 1:04 - Lower Body Warm-up 3:02 - First Superset: Zombie Squats and TKEs 5:24 - Second Superset: Reverse Lunges and Reverse Hyper 6:20 - Third Superset: Cyclist Squats and Hip Extensions 7:29 - Last Superset: Glute Ham Raises, Leg Extensions, Calf Raises 8:28 - Metcon, 30-20-10: Wall Balls and Row 10:33 - Metcon Results and Community at Fitness Culture, Outro

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No more insurance battles, wasted PTO, or $6,000 deductibles. Instead: cash-pay options, virtual visits, and personalized care across all 50 states. This healthcare revolution? All thanks to GLP-1. You're welcome. For more on this movement: radicallyhealthy.com #Healthcare #glp1 #Shorts

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