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This is a quick fire episode after I was 'challenged' about the importance of insulin sensitivity for weight loss over simply being concerned with energy balance. I discuss weight loss injections like semaglutide and the diabetes medication, metformin. Apologies for the audio quality! TOPICS 00:40 - Can certain 'insulin sensitivity' medications increase fat loss? 04:30 - The unknown impacts of increasing your insulin sensitivity 06:40 - The role of leptin and appetite hormones in weight loss maintenance 08:57 - What advice doctors should be giving alongside the prescription of "weight loss" drugs
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Obesity, a driver of inflammation, is prevalent in patients with HFpEF. Ileana Pina asks Ambarish Pandey about GLP-1 inhibitors and SGLT2 inhibitors in HFpEF. Are these drugs anti-inflammatory? https://www.medscape.com/viewarticle/993980?src=soc_yt -TRANSCRIPT- Ileana L. Piña, MD, MPH: Hello, everyone. I'm Ileana Piña, professor of medicine at Jefferson University Hospital in Philadelphia. I'm the chief of quality. This is my blog. We have been hearing a lot of conversation about obesity. It's coming out of our endocrine division and our weight management division. And the patients are asking for things like bariatric surgery and maybe a holistic program of weight loss. A lot of the primary care doctors are starting to recommend glucagon-like peptide-1 (GLP-1) receptor agonists for those patients. But we deal with patients with heart failure with preserved ejection fraction (HFpEF), and a lot of our phenotypes are patients with obesity who happen to have hypertension and/or diabetes, and they are difficult to manage. Inflammation, Obesity, and HFpEF Piña: For today's conversation, there is nobody better than Dr Ambarish Pandey, who has a HFpEF program at the University of Texas Southwestern. Ambarish, welcome. Give me your thoughts overall about the link between obesity, inflammation, and HFpEF. Ambarish Pandey, MD: Thank you, Dr Piña. I'm excited to be on your blog and I'm glad that we are discussing such an important topic. The burden of heart failure, particularly HFpEF, has been increasing and is not just affecting older individuals. We see more younger folks with obesity in our HFpEF clinic coming in with symptoms of shortness of breath and fluid buildup. Our understanding of HFpEF has evolved quite a bit over the past two or three decades. Initially, it was thought to be a disease of largely impaired myocardial relaxation. And then Walter Paulus was one of the pioneers who proposed the concept of inflammation leading to HFpEF, and obesity being one of the important drivers of the inflammation that leads to the development of HFpEF. Now our understanding of HFpEF has evolved to it being a multisystem disorder that leads to dysfunction in different organ systems. One of the cardinal features that drives this dysfunction is upregulation of inflammatory pathways, increased inflammatory burden — and a lot of that is driven by obesity. Obesity is one of the most important modifiable risk factors for HFpEF. Piña: It is so common. In my clinic the other day, probably 3 out of 4 patients were obese. Pandey: Up to 75% of patients that we see in our program are over the 30 BMI cut-off, and a lot of the literature that has come from US HFpEF cohorts shows a very high average BMI in these patients. Piña: When we talk about inflammation, what are the chemical pathways of inflammation? For example, a long time ago, we tried to block TNF-alpha and it didn't quite work out. So, what pathways are we talking about? Pandey: I think a lot more work needs to be done to really understand the key drivers of inflammation and what pathways are being upregulated. As we know, inflammation is most commonly identified by elevation in levels of C-reactive protein (CRP), which serves as a marker of increased inflammation, but the upstream upregulation in IL-1– and IL-6–mediated pathways has been implicated in inflammation that drives development of diseases like HFpEF. There is an ongoing trial of ziltivekimab, which is an IL-1 inhibitor in patients with HFpEF. That's the HERMES trial led by Paul Ridker, one of the pioneers of inflammatory therapies in heart disease. We are starting to understand more about the key molecular pathways that are driving it. And now we're starting to target them, with the hope that we can actually halt the progression of HFpEF and improve the symptom burden as well as the risk for adverse outcomes in these patients. Are GLP-1 Inhibitors Anti-inflammatory? Piña: Do you think that the GLP-1s, or even now the SGLT2 inhibitors, are anti-inflammatory since we really don't know all the pathways? Pandey: I do think that GLP-1s, by virtue of causing weight loss and reduction in visceral adiposity and the bad fat depots that exist in our body, have a significant anti-inflammatory effect. And if you look at the data from the STEP trials that were done, looking at weight loss effects of semaglutide, a commonly used GLP-1 inhibitor, there was a good 30%-40% reduction in CRP levels, and that suggests that there is a significant anti-inflammatory effect. Now, whether it's a direct effect on anti-inflammatory pathways or is related to weight loss is a matter of debate. Piña: Are you using GLP-1 inhibitors in your HFpEF clinic? And what trials can we look forward to seeing concerning the use of these agents? https://www.medscape.com/viewarticle/993980?src=soc_yt
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The ketogenic diet has gained immense popularity in recent years due to its ability to help people lose weight and improve their overall health. This high-fat, low-carb diet has been proven to be effective in burning fat and boosting energy levels. However, following a strict keto diet can be challenging for many individuals. That’s where keto supplements like keto gummies come in handy, providing a convenient way to support your ketogenic lifestyle.
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Keto gummies have become increasingly popular among keto dieters as they offer a delicious and convenient way to get your daily dose of essential nutrients. These gummies are typically infused with key ingredients like MCT oil, collagen, and electrolytes to support your ketogenic diet. Not only do they taste great, but they can also help curb your cravings and keep you on track with your keto lifestyle.
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When it comes to selecting keto supplements, it’s essential to choose high-quality products that are free from harmful additives and fillers. Look for keto gummies that are made with natural ingredients and are free from artificial colors and flavors. Additionally, consider the dosage and potency of the supplements to ensure you’re getting the right amount of nutrients to support your ketogenic diet.
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Whether you’re new to the ketogenic diet or a seasoned keto enthusiast, incorporating keto supplements like keto gummies into your routine can enhance your overall well-being and support your health goals. With the wide selection of keto products available at Chemist Warehouse, you can easily access high-quality supplements to help you stay on track with your keto journey. Take the first step towards a healthier lifestyle today by exploring the variety of keto supplements at Chemist Warehouse.
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As you embark on your keto journey, it’s important to arm yourself with the right tools and resources to support your health and fitness goals. Keto supplements like keto gummies can be a valuable addition to your daily routine, providing you with the essential nutrients you need to thrive on a ketogenic diet. Chemist Warehouse offers a diverse range of keto products to help you kickstart your keto lifestyle and achieve optimal results.
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Are you following a Weight Watchers diet but also interested in the keto lifestyle? You may be wondering how to integrate these two popular approaches to weight loss and health. One way to do this is by incorporating Weight Watchers Keto Gummies into your daily routine. These gummies are a convenient and delicious way to enjoy the benefits of both Weight Watchers and keto. In this article, we will explore how you can incorporate these gummies into your diet and make the most of their unique combination of ingredients.
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First, let’s take a look at the benefits of Weight Watchers Keto Gummies. These gummies are specifically designed to be low in carbs and sugar, making them a great option for those following a keto diet. They are also portion-controlled, which can help you stay on track with your Weight Watchers points. Additionally, these gummies are packed with nutrients and antioxidants, making them a healthy snack option.
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Now that you know the benefits of Weight Watchers Keto Gummies, let’s discuss how you can incorporate them into your diet. One way to enjoy these gummies is as a snack between meals. This can help to curb your cravings and keep you satisfied until your next meal. You can also enjoy these gummies as a dessert after dinner. They provide a sweet treat without all the added sugar and carbs.
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Another way to incorporate Weight Watchers Keto Gummies into your diet is to use them as a topping for salads or yogurt. This can add a burst of flavor and sweetness to your meal without adding unnecessary calories. You can also chop up the gummies and mix them into your favorite smoothie or protein shake for an extra boost of nutrients.
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To make the most of Weight Watchers Keto Gummies, it’s important to practice portion control. While these gummies are low in carbs and sugar, it’s still important to enjoy them in moderation. Be mindful of your portion sizes and avoid overindulging. It’s also a good idea to track your gummy consumption in your Weight Watchers app to ensure you’re staying within your daily points allowance.
In addition, be sure to drink plenty of water throughout the day when enjoying Weight Watchers Keto Gummies. Staying hydrated can help you feel full and satisfied, reducing the temptation to snack on unhealthy foods. Water can also help to flush out toxins and aid in digestion, keeping your body healthy and functioning properly.
Final Thoughts on Weight Watchers Keto Gummies
Integrating keto into a Weight Watchers diet can be a successful way to lose weight and improve your overall health. Weight Watchers Keto Gummies are a convenient and delicious way to enjoy the benefits of both approaches. By following the tips outlined in this article, you can make the most of these gummies and stay on track with your weight loss goals. Whether you enjoy them as a snack, dessert, or topping, Weight Watchers Keto Gummies are a versatile option for those looking to enhance their diet and lifestyle.
Overall, Weight Watchers Keto Gummies are a great addition to any weight loss plan. They are low in carbs and sugar, packed with nutrients, and convenient to enjoy on the go. By incorporating these gummies into your diet and following the tips provided, you can make the most of their unique combination of benefits. Whether you’re following a keto diet, a Weight Watchers plan, or both, these gummies can help you stay on track and reach your weight loss goals.
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Are GLP-1 The New Statin? Let’s Break It Down Are GLP-1 Drugs the Next Statin? A Medical Revolution or Just Hype? GLP-1s like Ozempic, Wegovy, and Mounjaro are everywhere—from your doctor’s office to TikTok. But are they just the latest weight loss trend, or are they reshaping medicine like statins did in the '90s? Grab your water and let's dive in. 💬 Let’s Connect: Facebook page: 👉https://www.facebook.com/GLP1journeyinreview Instagram: 👉https://www.instagram.com/lorrieissman Subscribe to YouTube channel: 👉https://www.youtube.com/@Glp1journeyinreview Subscribe for More: Follow GLP 1 Journey in Review for healthy recipes, weight loss tips, and personal insights into life on GLP-1 medications. #glp1journeyinreview #monjouro #semaglutide #weightmanagement #sustainableweightloss #weightlossupport #foodfreedom #foodforweightloss #glp1medication #weightlossjourney #medicaljourney #medicalbreakthrough #healthnews #hearthealth
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