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May 1: Aon study finds GLP-1 drugs help employers reduce medical costs by 7% in two years, despite high costs, due to improved health outcomes.

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In this episode of "In the Interim..." we revisit the ground-breaking seamless phase 2/3 clinical trial for the GLP-1 agonist, dulaglutide—better known as Trulicity. We discuss the intricacies of the adaptive trial design, and the unique features that helped expedite development by 12-18 months. Listeners will gain insight into how Bayesian algorithms and innovative statistical methods were pivotal in navigating a complex trial design, benefiting Eli Lilly's pipeline and changing the landscape of diabetes treatment. Key Highlights: —Outline of the trial design and the barriers faced during its inception in 2007-2008. —Explanation of the Clinical Utility Index and its role in adaptive randomization. —The DSMB's role and interaction with Bayesian decision-making models. —Simulation-based design to optimize development efficiencies. —Insights into the predictive power of the trial on weight loss outcomes in subsequent trials. Quotes: —"The trial was run entirely by Bayesian algorithms." – Scott Berry —"They believed this utility function was absolutely the right way to go forward." – Scott Berry For more head to berryconsultants.com.

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""Mi metto a dieta"" = """"Devo mangiare poco e soffrire la fame"""" ❌ FALSO! È questa mentalità che ti porta a FALLIRE continuamente! La chiave del dimagrimento senza sofferenza si chiama DENSITÀ CALORICA, e questi confronti ti lasceranno a bocca aperta: 🍝 PASTA AL POMODORO vs GNOCCHI AL POMODORO → Gli gnocchi hanno LA METÀ delle calorie! Stessa soddisfazione, metà impatto! 🍪 BISCOTTI vs GELATO → Con lo stesso apporto calorico puoi mangiare PIÙ DEL DOPPIO di gelato! Quale preferisci? 🍌 BANANE vs ANGURIA → Di anguria puoi mangiarne PIÙ DEL TRIPLO con le stesse calorie della banana! 🌰 FICHI SECCHI vs FICHI FRESCHI → I fichi freschi ti permettono di mangiare TRE VOLTE DI PIÙ dello stesso frutto! Ecco perché nel metodo Corposostenibile non contiamo calorie né eliminiamo alimenti: insegniamo a scegliere cibi a bassa densità calorica che ti permettono di: ✅ Mangiare PORZIONI ABBONDANTI ✅ Sentirti SODDISFATTO/A ✅ DIMAGRIRE senza fame ✅ Non rinunciare ai tuoi CIBI PREFERITI La chiave per eliminare la """"panza"""" non è mangiare meno, ma mangiare MEGLIO! 🔑 Il segreto è costruire piatti che ti facciano sentire sazio/a con meno calorie, permettendoti di entrare in deficit calorico SENZA NEMMENO ACCORGERTENE! Vuoi scoprire altri consigli pratici per dimagrire mangiando cibi che ami? Seguimi su IG @sciaudone.matteo! #alimentazione #benesserepsicologico #stiledivitasano #salute #dimagrimento #fitness "

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BEST & WORST Injection glp1 sites for weight loss: Does it matter? In this video, registered dietitian and GLP-1 user Ana Reisdorf dives deep into the topic of injection sites for GLP-1 medications like Wegovy, Zepbound, and others. She explains why the location of your injection matters, how it affects absorption, and whether one site is truly better than another. Ana shares her personal experience with different injection sites — the stomach, thigh, and back of the arm — and discusses their pros and cons, including pain levels, side effects, and ease of self-administration. She also addresses common myths, like whether certain sites help you lose more weight, and provides science-backed insight into whether site selection impacts results. Finally, she shares helpful tips for managing side effects and invites viewers to explore additional resources on her website and podcast. Studies cited: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/209637Orig1s000ClinPharmR.pdf?utm_source=chatgpt.com 📌 What You'll Learn in This Video: ✅The best places to inject GLP-1 medication ✅How each injection site affects comfort and effectiveness ✅Why rotating your injection site matters ✅Tips for minimizing bruising and irritation ✅Whether injection site impacts weight loss results ✅Common mistakes to avoid (like injecting into the buttocks) ✅How to handle allergic reactions or irritation ✅Where to find GLP-1-friendly meal plans and expert guidance ⏱️ Timestamps: 0:00 - Why injection site matters for GLP-1 medication 0:32 - 3 recommended GLP-1 injection sites 1:19 - Personal experience: stomach vs. thigh vs. arm 2:28 - Why you should NOT inject into the buttocks 2:47 - The importance of rotating injection sites 3:31 - Does injection site affect weight loss? What research says 4:49 - What to do if you're experiencing side effects 6:06 - Summary: what really matters for injection sites 6:34 - GLP1Hub website and resources 7:00 - Weekly podcast and sharing your own experience #glp1injection, #weightlossjourney, #dietitianadvice, #healthtipsdaily, #glp1support Want to connect more with GLP-1 Hub? Website: https://www.glp-1hub.com Instagram: https://www.instagram.com/glp1hub GLP-1 Hub store: https://glp-1hub.com/nutrition-guides... Newsletter: https://glp1hub.myflodesk.com/rn9j3lxjpp

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The demand for products that help us shed weight without having to do much stems from the consumer’s wish for fast and incredibly easy solutions. With this ever-growing trend in mind, it is easy to see why the ketogenic diet – the low carb, high fat eating plan – has grown to such popularity. People have hailed it for the quickness it helps individuals lose their weight. It is also this fast reputation that makes keto pills Shark Tank endorsed products recent bestsellers. Ever since the great success of the famous show, Shark Tank, a spin-off of the acclaimed show Dragon’s Den can be found all over the world, all sorts of new products or services by entrepreneurs attempt to impress the wealthy and successful business people on the panel in hope of getting an investment (and eventually the boom). The audience to shows such as these is not small, and mainstream media can offer new and upcoming companies with something to sell an impressive opportunity. With the growing trend in weight loss products, one wonders if keto pills Shark Tank are all they claim to be?

Understanding the Ketogenic Diet

First, a few basics for those unfamiliar with the keto diet: a ketogenic diet forces your body into ketosis – a thing that autocorrect really doesn’t like – where you no longer use carbohydrates as fuel, but instead start burning fat. This is accomplished by eating very few carbohydrates and disproportionately more fat than one normally would: essentially stuffing yourself with cheese and bacon, severely restricting your intake of just about anything else. Despite or perhaps because of this, some people have had great results with the keto diet.

But the transition to ketosis can be difficult, since a high-fat, low-carbohydrate diet takes some doing, as well as unpleasant at times, with many people suffering from symptoms dubbed the ‘keto flu’ when starting out. Hence the appeal of keto pills that claim they can help you attain ketosis on auto-pilot and with less effort. Do they really work, or are keto pills just the latest in a long line of weight-loss scams? Let’s see.Easy Weight Loss Exercises While Scrolling Phone Shortsmotivationfitnessweightlossytshorts

Evaluating the Claims of Keto Pills

Weight loss is one of the key selling points of keto pills pitched to viewers by Shark Tank; things are supposed to be sped up quickly if you take pills that put you in ketosis right away, such as ones containing exogenous ketones – ketones artificially introduced into the body to mimic those produced by the body when it’s in ketosis. Keto pill marketeers argue that their products allow you to ‘burn fat like crazy’ and increase energy levels while helping to suppress your appetite, all of which helps you to stick to the keto diet.

Of course, some users have reported positive results with keto pills, but that doesn’t mean you should trust those claims without question. As with most of the fad supplements lining the shelves at health-food shops, the products are working off the allure of a market that’s filled with too good to be true promises. Do you research, seek a second opinion from a healthcare specialist, and avoid overnight-success cures.

Are Keto Pills Endorsed by Shark Tank Legitimate?

Contestation of the keto pill by Shark Tank stems from one of the most common ethical issues of endorsement in social media: the validity of the endorsement. Some of the products presented on the show end up becoming real companies, but you might have gathered by now that the Shark Tank investors are not, in fact, endorsing any of those products. Many of the products featured on the show have companies behind them that claim (erroneously) to have received investment or endorsement from the Sharks.

If you find a keto pill that says it’s backed by Shark Tank, look into it! Check the official Shark Tank website to see if you can actually find that product (you won’t) or contact the show’s producers to make sure they back whatever it is. Check! Just because a product is pop-cultural – just because it’s claiming the favour of a popular TV show – doesn’t make it legitimate or effective.

Final Thoughts on Keto Pills Endorsed by Shark Tank

You might want to take keto pills promoted by Shark Tank, but that’s not a fast way to lose weight. Keto pills won’t suddenly work, or work miraculously, or make you lose weight faster than your natural habits would. But the weight loss industry is full of products that make false promises or are outright scams. How can you know if a product is legit? The world of keto pills is full of scams and false promises: the internet is filled with snake oil. Look up before you leap. Consult your health care provider. Check review websites.

In the end, the best way to achieve long-term weight loss is a combination of a healthy diet, exercise and lifestyle change, and keto pills can’t be a magic bullet in your quest for long-term success. Sustainable weight loss requires time and effort and entails a lifestyle change, so be cautious about using any weight loss pills and understand the expectations and possible side effects.

Summary:

In short, keto pills are a popular supplement that promise fast fat loss and more energy – promoted by notable celebrities, and showed on the Shark Tank. While weight loss from these pills is possible, although far from guaranteed, the industry is scattered with detrimental and misleading gimmicks. Buyer beware – do your research, consult with your doctor, and investigate the claims, and then decide for yourself to use keto pills, or not. There is no easy way to weight loss and fat loss. It requires a healthy and well-balanced diet (Ketogenic), healthy living and exercise.

At the end of the day, whether to try Shark Tank-endorsed Keto pills is a personal decision requiring careful thought and preferably some medical advice. Any sustained weight-loss regime requires commitment, hard work and a healthy lifestyle. So beware any weight loss pill, but especially promote the use of Keto pills. Also, there is no substitute for a nutritious diet and regular exercise.

However you choose to make a diet product work for you, remember to do your research and be realistic about your goals; consult a medical professional for advice and check with your doctor before starting any kind of weight loss programme; and keep in mind that convenience shouldn’t be our only indicator of a ‘good’ diet. No matter how appealing a pill from Shark Tank might sound, caring for yourself is important too. Ultimately, the responsible way to lose weight is through a safe and sustainable routine, maintaining the attitude of someone who believes they truly deserve a great, long life.

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