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💬 Dr Spencer Nadolsky is an obesity and lipid specialist, and an expert in GLP-1 care. He’s also the co-host of the Docs Who Lift podcast. ⚡️In this episode Spencer and I discuss emerging research around weight loss injections tirzepatide and semaglutide, known as Ozempic, Wegovy and Mounjaro - and discuss the proper use of these drugs. 🎧 Stay tuned to find out: ➡︎ Why old restrictions on weight loss drugs are no longer being enforced ➡ How a combo of GLP-1 and GIP may be even more revolutionary for weight loss ➡︎ Why most people have to take these drugs for life ➡︎ Why people get so angry when people lose weight on GLP-1s ➡︎ How GLP-1 drugs are going to make weight-loss surgery extinct 📕 Chapters 0:00 Intro 0:41 The non-weight loss benefits from GLP-1 use 4:55 Getting the dosage right 7:24 Drugs of the future 11:09 How to get started on a weight-loss injection 16:38 Why restrictions on weight loss drugs are being lifted 19:46 Why people get mad about GLP-1 use 23:57 Do you have to take these drugs for life? 27:55 Do fat cells have memory? 29:25 What if you want to stop GLP-1 use? 31:48 The mental health drawbacks of weight loss drugs 35:44 Unique insights from Spencer’s time with patients 38:47 Is excessive muscle loss really a big problem? 42:46 Should everyone be taking GLP-1s? 45:14 Will weight loss surgeries go extinct? 49:11 GLP supplements are a scam 📱 Connect with me: TikTok: https://www.instagram.com/drkaranrajan YouTube: https://www.youtube.com/@DrKaran Instagram: https://www.tiktok.com/@dr.karanr 📱 Connect with Spencer: Instagram: https://www.instagram.com/drnadolsky/ X: https://x.com/DrNadolsky 🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe 🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 🎙️ An OG Podcasts production.
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Semaglutide is a medication that has gained popularity for its effectiveness in helping individuals achieve weight loss. Originally approved for the treatment of type 2 diabetes, semaglutide has shown promising results in promoting weight loss when used at higher doses. While the injectable form of semaglutide has been the primary method of administration for weight loss, a new oral formulation has been developed as a more convenient option for patients. In this article, we will explore the pros and cons of semaglutide oral vs injection for weight loss.
Effectiveness
Semaglutide has been shown to be highly effective in promoting weight loss in individuals who are overweight or obese. Clinical trials have demonstrated that patients using semaglutide have achieved significant weight loss compared to those using a placebo. The injectable form of semaglutide has been more extensively studied and has been shown to produce greater weight loss results compared to the oral formulation. However, the oral form of semaglutide is still considered to be effective in helping individuals reach their weight loss goals.
Convenience
One of the primary advantages of the oral form of semaglutide is its convenience. Unlike the injectable form, which requires administration via a needle, the oral formulation can be taken simply by swallowing a pill. This may make it a more attractive option for individuals who are averse to needles or who have difficulty with injections. Additionally, the oral form of semaglutide may be more convenient for those who travel frequently or have busy schedules, as it can be taken without the need for refrigeration or special storage.
Adherence
Adherence to medication regimens is crucial for achieving successful weight loss results. Some individuals may find it more challenging to adhere to a medication that requires regular injections, as opposed to one that can be taken orally. The convenience of the oral form of semaglutide may help improve adherence rates among patients, leading to better outcomes in terms of weight loss. However, it is important to note that adherence is a personal factor that can vary among individuals, and some patients may still prefer the injectable form despite the convenience of the oral option.
Side Effects
Both the injectable and oral forms of semaglutide can cause side effects, though these are typically mild and temporary. Common side effects may include nausea, diarrhea, and constipation. Some individuals may experience injection site reactions with the injectable form of semaglutide. The oral form of semaglutide may be associated with a higher risk of gastrointestinal side effects due to its route of administration. Patients should discuss potential side effects with their healthcare provider before starting semaglutide for weight loss.
Cost
Cost may be a significant factor for individuals considering semaglutide for weight loss. The injectable form of semaglutide can be more expensive than the oral formulation, as it typically requires more frequent dosing. Insurance coverage may vary for these different forms of semaglutide, so patients should check with their provider to determine coverage and out-of-pocket costs. Cost considerations may influence a patient’s decision between the injectable and oral forms of semaglutide for weight loss.
In conclusion, both the oral and injectable forms of semaglutide have their own set of pros and cons when it comes to weight loss. The choice between the two will ultimately depend on individual preferences, lifestyle factors, and healthcare provider recommendations. Patients should discuss the options with their healthcare provider to determine the most suitable form of semaglutide for their weight loss goals.
FAQ
Q: Is semaglutide safe for weight loss?
A: Semaglutide has been shown to be safe and effective for weight loss in clinical trials. However, like any medication, it may cause side effects in some individuals. It is important to discuss any concerns with your healthcare provider before starting semaglutide for weight loss.
Q: How long does it take to see results with semaglutide for weight loss?

A: Results with semaglutide can vary among individuals, but many patients start to see weight loss within the first few weeks of treatment. It is important to follow a healthy diet and exercise regimen in conjunction with taking semaglutide to maximize results.
Q: Can semaglutide be used long-term for weight loss?
A: Semaglutide is typically used for a prescribed period of time to help individuals achieve weight loss goals. Your healthcare provider will determine the appropriate duration of treatment based on your individual needs. It is important to follow up with your provider regularly while taking semaglutide for weight loss.
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