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282: If you suffer from asthma, allergies, chronic coughs, or are sensitive to smoke and pollution... heck, even if you have gut issues, this episode will blow your mind! I bet you didn’t know that our gut health affects our lung health and vice versa! But think about it—if our gut impacts our brain, our skin, and even our mouth, why wouldn’t it also affect our lungs? In fact, our lungs require certain probiotics that our gut does not, and that’s exactly what we’re diving into today: how to support our lungs by supporting our gut with specific probiotics and GLP-1-supporting products. Not GLP-1 drugs like Ozempic! These are natural products that support the GLP-1 our bodies already produce, without side effects. I’m joined by Kara from ResBiotic to help shed light on the connection between lung health, gut health, and weight management. Topics Discussed: → The gut-lung axis → Our lung microbiome → How SCFAs (short-chain fatty acids) aid in lung health → Where SCFAs come from → Probiotics for our lungs → Signs and symptoms of compromised lungs → Foods that support lung health → GLP-1 support → Why gut health influences weight loss or gain → How to lose weight by changing our gut microbiome As always, if you have any questions for the show please email us at [email protected].  And if you like this show, please share it, rate it, review it and subscribe to it on your favorite podcast app.  Sponsored By: → resbiotic | https://resbiotic.com/ and use code DIGESTTHIS for 20% off Check Out Bethany: → Bethany’s Instagram: @lilsipper (https://www.instagram.com/lilsipper/) → YouTube (https://www.youtube.com/channel/UCIvGN6PeCYFayAnPuyOzrPQ) → Bethany’s Website (https://www.lilsipper.com/) → Discounts & My Favorite Products (https://hoo.be/lilsipper) → My Digestive Support Protein Powder (https://nuzest-usa.com/products/digestive-support-protein) → Gut Reset Book  (https://amzn.to/3zU7soG) → Get my Newsletters (https://www.lilsipper.com/subscribe/) (Friday Finds)

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Curious about GLP-1 medications like Ozempic, Wegovy, and Mounjaro for weight loss? In this deep dive, we uncover their jaw-dropping efficacy (up to 20% weight loss!), how they work, side effects, and long-term impact. We’ll explore who they’re best for—think BMI 30+ or 27+ with conditions like diabetes—plus the latest on Wegovy’s $499/month program for private insurance folks. Not into meds? Discover a functional medicine approach to tackle weight naturally with gut health, hormonal balance, and detox strategies—no GLP-1s needed! From clinical trials to real-world results, we’ve got the science, safety, and sustainability covered. Hit subscribe for weekly health insights every Sunday at 7 PM CST, and let’s heal together! Keywords: GLP-1 medications, weight loss drugs, Ozempic, Wegovy, Mounjaro, functional medicine weight loss, gut health, hormonal balance, obesity treatment, BMI, side effects, long-term weight management" Citations GLP-1 Efficacy in Weight Loss (STEP 1, SCALE, SURMOUNT-1 Trials) Source: Wilding, J. P. H., et al. (2021). "Once-Weekly Semaglutide in Adults with Overweight or Obesity." New England Journal of Medicine, 384(11), 989-1002. URL: https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 Liraglutide Efficacy (SCALE Trial) Source: Pi-Sunyer, X., et al. (2015). "A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management." New England Journal of Medicine, 373(1), 11-22. URL: https://www.nejm.org/doi/full/10.1056/NEJMoa1411892 Tirzepatide Efficacy (SURMOUNT-1 Trial) Source: Jastreboff, A. M., et al. (2022). "Tirzepatide Once Weekly for the Treatment of Obesity." New England Journal of Medicine, 387(3), 205-216. URL: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 GLP-1 Mechanism of Action Source: Drucker, D. J. (2018). "Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1." Cell Metabolism, 27(4), 740-756. URL: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30136-8 Side Effects and Safety Source: Filippatos, T. D., et al. (2021). "Safety of GLP-1 Receptor Agonists: A Review of the Evidence." Diabetes, Obesity and Metabolism, 23(S2), 19-29. URL: https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.14394 Compounded GLP-1 Controversy Source: U.S. Food and Drug Administration (2024). "FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss." URL: https://www.fda.gov/drugs/human-drug-compounding/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss Wegovy $499/Month Program Source: Novo Nordisk (2025). "Novo Nordisk Announces New Access Program for Wegovy." Press Release (assumed based on script info as of March 23, 2025). URL: https://www.novonordisk-us.com/media/news-releases.html (specific press release not yet available; check Novo Nordisk’s site for updates post-March 2025). Functional Medicine Approach to Weight Loss Source: Institute for Functional Medicine (IFM). "Addressing the Root Causes of Obesity." URL: https://www.ifm.org/news-insights/addressing-root-causes-obesity/ Gut Health and Weight Loss Source: Cani, P. D., et al. (2019). "Gut Microbiota and Obesity: Lessons from the Microbiome." Nature Reviews Endocrinology, 15(6), 323-334. URL: https://www.nature.com/articles/s41574-019-0177-8 Hormonal Balance and Inflammation Source: Hyman, M. (2020). "The Functional Medicine Approach to Obesity and Weight Management." Integrative Medicine: A Clinician’s Journal, 19(3), 12-18. URL: https://www.imjournal.com/open-access-articles/the-functional-medicine-approach-to-obesity-and-weight-management Weight Regain After GLP-1 Discontinuation Source: Wilding, J. P. H., et al. (2022). "Weight Regain and Cardiometabolic Effects After Withdrawal of Semaglutide: The STEP 1 Trial Extension." Diabetes, Obesity and Metabolism, 24(8), 1553-1564. URL: https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.14725 Cardiovascular and Other Benefits Source: Marso, S. P., et al. (2016). "Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes." New England Journal of Medicine, 375(19), 1834-1844. URL: https://www.nejm.org/doi/full/10.1056/NEJMoa1607141

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The research is clear: Eating greens can suppress hunger, reduce food intake, result in weight loss, and do so much more for our overall health, but is one veggie better than another? New subscribers to our e-newsletter always receive a free gift. Get yours here: https://nutritionfacts.org/subscribe/. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/using-prebiotics-intact-grains-thylakoids-and-greens-to-boost-our-glp-1-for-weight-loss and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at https://nutritionfacts.org/video/using-prebiotics-intact-grains-thylakoids-and-greens-to-boost-our-glp-1-for-weight-loss. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources: https://nutritionfacts.org/translations-info/ https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Books: https://nutritionfacts.org/books • Shop: https://drgreger.org • Facebook: https://www.facebook.com/NutritionFacts.org • Twitter: https://twitter.com/nutrition_facts • Instagram: https://www.instagram.com/nutrition_facts_org

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Understanding GLP1 and Its Effects Exploring the impact of GLP1 on dopamine pathways and appetite control. #Health #GLP1 GLP1 stands for Glucagon-Like Peptide-1, which is a hormone produced in the gut that plays a crucial role in glucose metabolism and appetite regulation. When released into the bloodstream after a meal, GLP1 acts on multiple organs, including the brain, to control blood sugar levels and suppress appetite. One of the important ways GLP1 affects the brain is by influencing dopamine pathways. Dopamine is a neurotransmitter associated with pleasure and reward, and it plays a role in regulating food intake. GLP1 has been found to increase the release of dopamine in the brain's reward centers, which can lead to a decrease in cravings for high-calorie foods. Furthermore, GLP1 also acts on specific brain regions involved in appetite control. It communicates with the hypothalamus, a region responsible for integrating signals related to hunger and satiety. GLP1 activates certain neurons in the hypothalamus that suppress appetite and promote a feeling of fullness. In addition to its impact on dopamine pathways and appetite control, GLP1 has other beneficial effects on health. It stimulates the pancreas to produce more insulin, a hormone that lowers blood sugar levels. This is particularly important for people with type 2 diabetes, as GLP1-based medications have been developed to help manage blood sugar levels. Moreover, GLP1 slows down the rate at which the stomach empties, prolonging the feeling of fullness after a meal. This can lead to reduced food intake and weight loss, making GLP1 an attractive target for the treatment of obesity. GLP1-based medications, such as GLP1 receptor agonists, have been developed to mimic the effects of GLP1 and are used in the treatment of both type 2 diabetes and obesity. These medications help regulate blood sugar levels, promote weight loss, and reduce food intake by targeting GLP1 receptors in the body. In conclusion, GLP1 is a hormone that plays a crucial role in glucose metabolism and appetite regulation. Its effects on dopamine pathways and appetite control contribute to the regulation of food intake and can be targeted by medications for the treatment of conditions like type 2 diabetes and obesity.

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