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Key Points Question Are glucagon-like peptide-1 receptor agonists semaglutide and liraglutide, which were originally introduced for the treatment of type 2 diabetes and are frequently prescribed due to their weight loss properties, associated with disproportionately increased reporting of suicidality? Findings This disproportionality analysis through the case-control design based on the World Health Organization global database collecting suspected adverse drug reactions, identified a disproportionality signal of suicidal ideation with semaglutide, which remained significant when comparing semaglutide with dapagliflozin and metformin and in the subgroup of patients with coreported use of antidepressants and benzodiazepines. Meaning A detected signal of semaglutide-associated suicidal ideation warrants urgent clarification. Abstract Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained use primarily due to their weight-reduction effects, although a regulatory review was undertaken for potential suicidality concern. Objectives To evaluate potential signals for suicidal and self-injurious adverse drug reactions (ADRs) associated with the GLP-1 RAs semaglutide and liraglutide. Design, Setting, and Participants Disproportionality analysis through the case-control design using the World Health Organization (WHO) global database of suspected ADRs. Participants were clinical patients worldwide experiencing an ADR suspectedly attributable to semaglutide or liraglutide in the database from inception to August 30, 2023. Data were analyzed from September to December 2023. Exposure Treatment with semaglutide or liraglutide regardless of indication or treatment duration. Main Outcomes and Measures Reporting odds ratio (ROR) and the bayesian information component (IC) with 95% CIs were calculated as measures of disproportionate reporting of suicidal and self-injurious ADRs associated with semaglutide and liraglutide compared with all other medications. Sensitivity analyses were conducted including patients with coreported use of antidepressants and benzodiazepines and using dapagliflozin, metformin, and orlistat as comparators. A disproportionality signal was considered when the lower limits of the ROR and IC were above 1 and 0, respectively. Results A total of 107 (median [IQR] age 48 [40-56] years; 59 female patients [55%]) and 162 (median [IQR] age 47 [38-60] years; 100 female patients [61%]) cases of suicidal and/or self-injurious ADRs were reported between November 2000 and August 2023 with semaglutide and liraglutide, respectively. Significant disproportionality was detected only for semaglutide-associated suicidal ideation (ROR, 1.45; 95% CI, 1.18-1.77; IC, 0.53; 95% CI, 0.19-0.78), which remained significant in patients with coreported use of antidepressants (ROR, 4.45; 95% CI, 2.52-7.86; IC, 1.96; 95% CI, 0.98-2.63) and benzodiazepines (ROR, 4.07; 95% CI, 1.69-9.82; IC, 1.67; 95% CI, 0.11-2.65), when compared with dapagliflozin (ROR, 5.56; 95% CI, 3.23-9.60; IC, 0.70; 95% CI, 0.36-0.95), metformin (ROR, 3.86; 95% CI, 2.91-5.12; IC, 1.20; 95% CI, 0.94-1.53) and orlistat (ROR, 4.24; 95% CI, 2.69-6.69; IC, 0.70; 95% CI, 0.36-0.95). Conclusions and Relevance This study using the WHO database found a signal of semaglutide-associated suicidal ideation, which warrants urgent clarification.

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Obesity has become a major public health concern worldwide, with millions of people struggling to lose weight and improve their overall health. In recent years, there has been growing interest in the use of medications to help individuals achieve their weight loss goals. One such medication that has gained attention is semaglutide, a type 2 diabetes drug that has been found to be effective in promoting weight loss.

Understanding Semaglutide Starting Dose

Semaglutide is a glucagon-like peptide-1 receptor agonist that works by mimicking the effects of a hormone that regulates blood sugar levels and appetite. It has been shown to not only help individuals with type 2 diabetes better manage their blood sugar levels but also promote weight loss. The starting dose of semaglutide for weight loss is crucial in determining its effectiveness and ensuring that individuals are able to achieve their weight loss goals.

When starting on semaglutide for weight loss, it is important to work closely with a healthcare provider to determine the appropriate starting dose. The recommended starting dose of semaglutide for weight loss is usually lower than the dose used for managing type 2 diabetes. This lower starting dose helps minimize the risk of side effects and allows individuals to gradually adjust to the medication.

Individuals who are prescribed semaglutide for weight loss should follow their healthcare provider’s instructions carefully and monitor their progress regularly. It is important to keep track of any changes in weight, appetite, or side effects while taking semaglutide. By starting with the right dose and closely monitoring progress, individuals can maximize the benefits of semaglutide for weight loss.

Benefits of Starting Semaglutide at the Right Dose

Starting semaglutide at the right dose is essential for achieving effective weight loss. By starting with a lower dose and gradually increasing as needed, individuals can minimize the risk of side effects such as nausea, vomiting, or diarrhea. This approach allows the body to adjust to the medication and increases the likelihood of success in reaching weight loss goals.

In addition to promoting weight loss, semaglutide has been shown to have other health benefits, such as improving blood sugar control and reducing the risk of cardiovascular events. By starting at the right dose, individuals can maximize these benefits and improve their overall health. It is important to work closely with a healthcare provider to ensure that the dose of semaglutide is tailored to individual needs and goals.

Overall, starting semaglutide at the right dose is key to achieving effective weight loss and improving overall health. By working with a healthcare provider to determine the appropriate starting dose and closely monitoring progress, individuals can optimize the benefits of semaglutide and reach their weight loss goals.





Frequently Asked Questions

Q: What is the recommended starting dose of semaglutide for weight loss?

A: The recommended starting dose of semaglutide for weight loss is usually lower than the dose used for managing type 2 diabetes, to minimize the risk of side effects and allow for gradual adjustment to the medication.

Q: What are the potential side effects of semaglutide for weight loss?

A: Some potential side effects of semaglutide for weight loss include nausea, vomiting, or diarrhea. These side effects can often be managed by starting at a lower dose and gradually increasing as needed.

Q: How long does it take to see results with semaglutide for weight loss?

A: Individual results may vary, but many people start to see weight loss within the first few weeks of starting semaglutide. It is important to be patient and consistent with taking the medication as directed by a healthcare provider.

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Around 220,000 people with “greatest need” are expected to receive Mounjaro, also known as tirzepatide and made by Lilly through the NHS over the next three years. • Subscribe to ITV News on YouTube: http://bit.ly/2lOHmNj • Get breaking news and more stories at http://www.itv.com/news Follow ITV News on TikTok https://www.tiktok.com/@itvnews?lang=en Follow ITV News on Instagram: https://www.instagram.com/itvnews/ Follow ITV News on Facebook: https://www.facebook.com/itvnews/ Follow ITV News on X: https://twitter.com/itvnews

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Are you curious about real results on Tirzepatide? I know I was when I was doing my research on this peptide. In this video, I’m sharing my honest GLP-1 weight loss journey, my real fitness truths at 33 and what 5 weeks on Tirzepatide have really looked like for me. I started Tirzepatide on May 29th at 212 lbs, and by July 3rd — 5 weeks later... I’m at 204.4 lbs. But this journey is about so much more than the number on the scale. I’m talking about how my appetite has changed, side effects, the mindset shifts I’m making, and how I’m finally building habits that fit my real life as a 33-year-old single mom entrepreneur. If you’re in your 30s struggling to lose weight, you’re not alone. Let’s talk about what really works, what doesn’t, and how we can do this without losing ourselves in the process. 👇 Drop your questions below and let’s support each other! 📌 Don’t forget to LIKE, COMMENT & SUBSCRIBE for more Tirzepatide updates, realistic weight loss tips, and honest wellness talks. #Tirzepatide #GLP1 #WeightLossJourney #RealFitnessTruths #FitpreneurUnleashed

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