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Dr. Riccardo De Giorgi is a Clinical Lecturer at the University of Oxford’s Department of Psychiatry and a senior psychiatric trainee with Oxford Health NHS Foundation Trust. Dr. De Giorgi is deeply engaged in clinical practice and academic research, focusing on treatment-resistant mood disorders. His work explores the role of immunological and metabolic factors in mental illness and the potential for repurposing existing medications, such as statins and GLP1 receptor agonists, to treat patients who don't respond to conventional therapies. Overall, Dr. Riccardo is a passionate educator in the field of psychiatry who is always looking at these disorders from an embodied perspective where the mind is not separate from the body. Note: When discussing ways in which compounds may enter the brain, I used the term "circumventricular brain regions" when the most appropriate way to describe it is through "circumventricular organs (CVOs). This might be too pedantic, but in Science, terminology is very important. Dr. Riccardo's work and papers discussed: GLP-1 Paper: http://doi.org/10.1038/s44220-025-00390-x Statin Paper: DOI: 10.1016/j.jad.2022.05.113 Creatine Paper: http://doi.org/10.1016/j.euroneuro.2024.10.004 Follow Dr.Riccardo's work: https://x.com/rdegiorgi https://orcid.org/0000-0001-5984-8696 Chapters: 0:00 Intro 2:14 Dr.Riccardo's research 4:07 Treatment Resistance in Psychiatry 8:07 Anhedonia and Depression 9:16 Side effects of psychiatric medications 13:43 Ketogenic diet and metabolic interventions 18:20 Do we need to target the brain to heal it? 22:45 Blood-Brain barrier 25:29 GLP-1 RAs and Anhedonia 29:35 Statins & Depression 33:24 Creatine Monohydrate 35:25 Medication and Increased Suicidality 41:06 Stigma and Perceived Uniqueness of Psychiatry 46:03 Biggest Challenges in Psychiatry 49:48 Problems in Science 51:57 Science Denial 52:50 Tips for those struggling #glp1medication #mentalhealth #metabolichealth #ozempic #psychiatry #psychology

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Semaglutide, a promising medication that belongs to the class of glucagon-like peptide-1 (GLP-1) receptor agonists, has garnered attention for its potential to aid in weight loss. This medication was initially approved for the treatment of type 2 diabetes but has since shown remarkable efficacy in promoting weight loss in individuals who are overweight or obese. Many people are curious about how much weight loss they can expect with Semaglutide, so let’s delve into the details.

Understanding Semaglutide and Weight Loss

Semaglutide works by mimicking the effects of GLP-1, a hormone that helps regulate blood sugar levels and decrease appetite. By activating GLP-1 receptors in the brain, Semaglutide can reduce feelings of hunger and increase feelings of fullness, leading to reduced food intake and ultimately, weight loss.

Studies have shown that Semaglutide can help individuals achieve significant weight loss when used as part of a comprehensive weight management plan that includes a reduced-calorie diet and increased physical activity. Clinical trials have demonstrated that Semaglutide can lead to substantial weight loss compared to a placebo, making it a promising option for individuals struggling to lose weight through diet and exercise alone.

It is important to note that the amount of weight loss experienced with Semaglutide can vary from person to person. Factors such as starting weight, adherence to the treatment plan, and individual metabolic differences can all influence the rate and amount of weight loss achieved with Semaglutide.

Setting Realistic Expectations

When considering Semaglutide as a potential treatment for weight loss, it is essential to set realistic expectations. While some individuals may experience rapid and significant weight loss with Semaglutide, others may see more gradual progress. It is crucial to remember that sustainable weight loss takes time and consistent effort, and Semaglutide should be used as a tool to support healthy lifestyle changes rather than a quick-fix solution.

Experts recommend aiming for a gradual and steady weight loss of 1-2 pounds per week, which is considered a safe and sustainable rate of weight loss. By incorporating Semaglutide into a comprehensive weight management plan that includes a balanced diet, regular physical activity, and behavioral support, individuals can increase their chances of long-term success in achieving their weight loss goals.

Consulting with a Healthcare Provider

Prior to starting Semaglutide or any new weight loss medication, it is crucial to consult with a healthcare provider to discuss the potential benefits and risks. A healthcare provider can evaluate your individual health status, weight loss goals, and medical history to determine if Semaglutide is a suitable option for you.





Additionally, a healthcare provider can provide guidance on how to use Semaglutide effectively, monitor your progress, and address any concerns or side effects that may arise during treatment. Working closely with a healthcare provider can help ensure that you are safely and effectively using Semaglutide to support your weight loss journey.

Conclusion

In conclusion, Semaglutide is a promising medication that can aid in weight loss when used as part of a comprehensive weight management plan. While the amount of weight loss experienced with Semaglutide can vary, individuals can achieve significant results by combining this medication with healthy lifestyle changes. By setting realistic expectations, consulting with a healthcare provider, and committing to sustainable weight loss strategies, individuals can increase their chances of successful weight loss with Semaglutide.

Frequently Asked Questions

1. How quickly can I expect to see weight loss results with Semaglutide?

Weight loss results with Semaglutide can vary, but many individuals may start to see progress within the first few weeks of treatment. It is essential to be patient and consistent with your weight loss efforts to achieve long-term success.

2. Are there any potential side effects or risks associated with Semaglutide?

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Like any medication, Semaglutide may cause side effects in some individuals. Common side effects may include nausea, vomiting, diarrhea, and constipation. It is important to discuss any concerns or side effects with your healthcare provider.

3. Can I stop taking Semaglutide once I reach my weight loss goals?

It is essential to follow your healthcare provider’s guidance on when and how to discontinue Semaglutide. Abruptly stopping the medication may lead to weight regain, so it is crucial to have a plan in place for transitioning off Semaglutide once your weight loss goals are achieved.

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The ketogenic diet has gained massive popularity in recent years for its ability to help people lose weight and improve their overall health. One of the key components of the keto diet is ketosis, a metabolic state where the body burns fat for fuel instead of carbohydrates. However, achieving and maintaining ketosis can be challenging, especially for beginners. That’s where K1 Keto Gummies come in. These gummies are specially formulated to accelerate the process of ketosis, making it easier for you to reach your weight loss goals.

What are K1 Keto Gummies?

K1 Keto Gummies are a convenient and delicious way to support your ketogenic journey. These gummies are packed with essential ingredients that help your body transition into ketosis more quickly and effectively. By incorporating K1 Keto Gummies into your daily routine, you can kickstart your metabolism and start burning fat for fuel efficiently.

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Key Ingredients in K1 Keto Gummies

1. BHB (Beta-Hydroxybutyrate): BHB is a ketone body that plays a crucial role in the process of ketosis. When you consume K1 Keto Gummies, the BHB in the gummies helps your body enter ketosis by providing it with a source of exogenous ketones. This allows your body to start burning fat for fuel instead of glucose, leading to faster weight loss and increased energy levels.

2. MCT Oil: Medium-chain triglycerides (MCTs) are a type of fat that is easily digested and converted into ketones by the liver. MCT oil in K1 Keto Gummies helps boost your ketone levels, making it easier for your body to stay in ketosis. Additionally, MCT oil can help improve brain function and increase feelings of fullness, making it easier for you to stick to your keto diet.

3. Green Tea Extract: Green tea extract is rich in antioxidants and catechins, which can help boost metabolism and promote fat loss. By including green tea extract in K1 Keto Gummies, this supplement can help enhance the fat-burning effects of ketosis and support your weight loss goals.

How to Use K1 Keto Gummies

To experience the full benefits of K1 Keto Gummies, simply take the recommended dosage as directed on the packaging. For best results, incorporate these gummies into your daily routine along with a healthy ketogenic diet and regular exercise. With consistent use, you can accelerate your journey into ketosis and achieve your weight loss goals faster.

Remember that individual results may vary, and it’s essential to consult with your healthcare provider before starting any new supplement regimen, especially if you have any underlying medical conditions or are taking medications.

Benefits of K1 Keto Gummies

1. Accelerated Ketosis: By providing your body with essential ingredients like BHB, MCT oil, and green tea extract, K1 Keto Gummies help accelerate the process of ketosis, making it easier for you to reach your weight loss goals.

2. Increased Energy Levels: When your body is in ketosis, it’s burning fat for fuel, which can lead to a steady and sustainable source of energy throughout the day. K1 Keto Gummies can help boost your energy levels and improve your overall vitality.

3. Enhanced Weight Loss: With the support of K1 Keto Gummies, you can experience faster and more significant weight loss results. These gummies help curb cravings, enhance fat burning, and support a healthy metabolism, making it easier for you to shed those extra pounds.

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