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Struggling with constipation on GLP-1 meds? In this episode, we break down why these meds slow digestion and how to get things moving again. From fiber and hydration hacks to probiotics, exercise, and doctor-approved solutions, we’ve got the best tips to keep your gut happy. Don’t let constipation derail your journey—tune in for practical advice (and a few laughs) to get back on track

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Weight loss can be a challenging journey for many individuals. From strict diets to rigorous exercise routines, finding a sustainable solution to shedding those extra pounds can often feel like an uphill battle. One emerging option that has gained popularity in recent years is the use of semaglutide, a medication traditionally used to treat type 2 diabetes. This drug has shown promising results in promoting weight loss, sparking interest among those looking to slim down. However, determining the right dose of semaglutide for weight loss can be a complex process that requires careful consideration and guidance from healthcare professionals.

The Science Behind Semaglutide for Weight Loss

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the effects of a hormone produced in the gut. This hormone helps regulate blood sugar levels and appetite, leading to reduced food intake and weight loss. When used in higher doses than those typically prescribed for diabetes management, semaglutide has been found to significantly impact weight loss in individuals with obesity.





Research studies have shown that semaglutide can lead to greater weight loss compared to other weight loss medications or lifestyle interventions. In fact, clinical trials have demonstrated that individuals using semaglutide experienced an average weight loss of around 15-20% of their initial body weight over the course of a year. These results have sparked excitement within the medical community and among patients struggling with obesity.

Despite its effectiveness, semaglutide is not a magic solution for weight loss. It is essential to combine medication with healthy lifestyle habits such as balanced nutrition and regular physical activity to achieve sustainable results. Additionally, the right dosage of semaglutide varies from person to person and should be determined based on individual factors such as weight, medical history, and response to the medication.

Factors to Consider When Determining the Right Dose

When it comes to finding the right dose of semaglutide for weight loss, several factors come into play. Healthcare providers will consider the individual’s baseline weight, any existing medical conditions, and previous experiences with weight loss medications. In general, the standard starting dose of semaglutide for weight loss is 0.25 mg once weekly, with the option to increase the dosage incrementally based on the individual’s progress and tolerance.

It is crucial for patients to communicate openly with their healthcare providers about their experiences with the medication, including any side effects or challenges they may encounter. Adjustments to the dose may be necessary to optimize the benefits of semaglutide while minimizing any adverse effects. Close monitoring by a healthcare professional is essential to ensure that the medication is used safely and effectively for weight loss.

In addition to the dose of semaglutide, other lifestyle factors play a significant role in achieving successful weight loss outcomes. Engaging in regular physical activity, consuming a balanced diet rich in nutrients, and prioritizing adequate sleep and stress management are all essential components of a holistic approach to weight management. Semaglutide should be seen as a tool to support these efforts rather than a standalone solution.

Conclusion

Overall, semaglutide offers a promising option for individuals seeking to achieve meaningful weight loss and improve their overall health. Finding the right dose of semaglutide for weight loss requires careful consideration and collaboration with healthcare providers. By incorporating this medication into a comprehensive weight loss plan that includes healthy lifestyle habits, individuals can increase their chances of successful and sustainable weight loss. As with any medication, it is important to approach semaglutide with caution and seek guidance from qualified healthcare professionals to ensure safe and effective use.

Weight loss can be a challenging journey for many individuals. From strict diets to rigorous exercise routines, finding a sustainable solution to shedding those extra pounds can often feel like an uphill battle. One emerging option that has gained popularity in recent years is the use of semaglutide, a medication traditionally used to treat type 2 diabetes. This drug has shown promising results in promoting weight loss, sparking interest among those looking to slim down. However, determining the right dose of semaglutide for weight loss can be a complex process that requires careful consideration and guidance from healthcare professionals.

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Welcome to The Peptide Podcast. Today we’re going to talk about something that almost everyone on a GLP-1 journey hits eventually, the weight loss plateau. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. It starts like this: you begin a GLP-1 like semaglutide or tirzepatide, and for the first few weeks or months, the weight seems to fall off. You’re eating less, not obsessing over food, and for the first time in a long time, it feels… easy. Then one day, the scale just stops moving. You’re not doing anything different. You’re still taking the meds. Still trying to eat well. Maybe you’re walking more or lifting weights. But suddenly, nothing’s happening—and the frustration kicks in. Sound familiar? Let’s talk about what’s really going on. 1. What Causes the Plateau? First of all, if you’re in this place right now: you didn’t mess up. GLP-1s are incredibly effective at reducing appetite and creating an initial calorie deficit, which is why people lose weight so quickly in the beginning. But your body isn’t just going to let that continue unchecked. It adapts. This is called adaptive thermogenesis—a fancy way of saying your body becomes more efficient. You start burning fewer calories at rest than you did before. Your resting metabolic rate actually drops beyond what you'd expect just from losing weight alone. It’s a survival mechanism. So what worked at the beginning—eating less and moving a bit more—might no longer be enough to keep the scale moving. This is totally normal. 2. Metabolism & Muscle: Why Strength Training Matters Now More Than Ever So now that we know why the plateau happens, let’s talk about things we can do to help us get over it. Something that often gets overlooked but is absolutely critical—especially if you’re on a GLP-1 or in any kind of calorie deficit. Resistance training is not optional. It’s non-negotiable. Here’s why. When you’re losing weight—whether it’s from a medication like semaglutide or just eating in a calorie deficit—your body isn’t just pulling energy from fat. If you’re not careful, it’s also going to break down lean muscle tissue. And the more muscle you lose, the slower your metabolism gets. Why? Because muscle is metabolically active tissue. It burns calories even when you’re doing absolutely nothing. So if you’re not actively sending a signal to your body to keep that muscle, it’ll start to let it go. That’s where resistance training comes in. When you lift weights or do bodyweight exercises—think squats, push-ups, resistance bands, even heavy housework—you’re telling your body: “Hey, I need this muscle. Don’t burn it for fuel.” This is especially important for those on GLP-1s because these meds reduce appetite so significantly that you might not be eating enough protein—or enough calories in general—to maintain muscle without that extra stimulus. So if you’ve hit a plateau or want to prevent one, ask yourself: Am I strength training at least two to three times a week? Am I prioritizing movements that challenge large muscle groups—like legs, glutes, chest, and back? Am I fueling my workouts with enough protein? And let me be really clear, you don’t have to become a gym rat. You don’t have to lift crazy heavy weights. But you do have to move your muscles in a meaningful, consistent way. Protecting your lean mass is one of the best ways to keep your metabolism humming—not just during your weight loss journey, but after it too. Because this isn’t about just losing weight—it’s about building a strong, metabolically healthy body that can maintain that weight loss for life. 3. Mindset Check: The Plateau Is Not a Failure Now, let’s get into the mental side of this journey—because it’s just as important as nutrition, movement, and medication. One of the biggest challenges people face—especially when progress slows—is the mental roller coaster that comes with watching the scale. And I’ll be honest: weighing yourself every single day is not ideal. Here’s why. Your body weight naturally fluctuates. Daily. And those fluctuations have nothing to do with your actual fat loss or long-term progress. Instead, the number on the scale is influenced by things like: Hydration status – If you’re slightly dehydrated, the scale may dip. But if you drank a ton of water the day before or had more salty food, it may go up due to water retention. Glycogen stores – When you eat carbs, your body stores them in your muscles and liver as glycogen, and for every gram of glycogen, your body stores about 3–4 grams of water. So a...

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