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The Future of Obesity Therapy and the Development of GLP-1 Drugs Today, we have Tirzepatide (brand names: Zepbound, Mounjaro) and Semaglutide (Ozempic, Wegovy). Who’s next? When will the next weight loss injection — or finally a weight loss pill — be released in the coming years? Let’s take a look at the overview table together. From left to right: This table provides an overview of upcoming and future pharmaceutical drugs for weight loss or metabolic disorders, categorized by year, company, drug name, and pharmaceutical formulation (oral or injection).  Orforglipron (Eli Lilly) – Oral GLP‑1RA small molecule  taken once daily Clinical results: Phase III ACHIEVE‑1 (type 2 diabetes): Lowered A1C by 1.3–1.6 pp and body weight by ~7.9% (~16 lb) at 40 weeks vs ~1.6% weight loss for placebo businessinsider.com+5   Oral Semaglutide – Novo Nordisk (“Rybelsus”)  Novo Nordisk has submitted an application to the U.S. Food and Drug Administration (FDA) for oral semaglutide (a 25 mg once‑daily formulation of Wegovy) aimed at chronic weight management: ,based on encouraging Phase III OASIS‑4 data 25md oral Semaglutide is showing around 13.6 % mean weight loss at 64 weeks In May 2025, the FDA officially accepted the NDA and will decide in Q4 2025 Retatrutide (LY‑3437943) – Eli Lilly Mechanism: A triple agonist targeting GLP‑1, GIP, and glucagon receptors prnewswire.com+15 hase 2 (48 weeks): 8 mg dose → –22.8% body weight reduction 12 mg dose → –24.2% body weight reduction (~58 lb) Also reduced liver fat in patients with metabolic steatotic liver disease VK2735 – Viking Therapeutics (injectable + oral) Mechanism: Dual GLP‑1 and GIP receptor agonist (similar to tirzepatide) en.wikipedia.org. Formulations: Subcutaneous (weekly): Phase 2 data showed up to 14.7% weight loss in 13 weeks, with 88% of subjects achieving ≥10% weight loss pharmexec.com. Oral (daily): Phase 1 MAD study: Up to 8.2% weight loss over 28 day

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Apple Cider Vinegar (ACV) and the ketogenic diet have both gained popularity in recent years for their potential health benefits. ACV is known for its ability to aid in weight loss, improve digestion, and regulate blood sugar levels. On the other hand, the ketogenic diet focuses on putting the body into a state of ketosis, where it burns fat for fuel instead of carbohydrates. But what happens when you combine ACV with ketosis? In this article, we will explore the benefits of incorporating ACV into a ketogenic lifestyle and how it can enhance your results.

The Power of ACV in Ketosis

ACV has been shown to have several benefits that can complement the ketogenic diet. One of the key benefits of ACV is its ability to help regulate blood sugar levels. By stabilizing blood sugar, ACV can help prevent spikes and crashes in insulin levels, which is important for those following a ketogenic diet. When blood sugar levels are stable, the body is more likely to stay in ketosis and burn fat for fuel.

Another benefit of ACV is its ability to aid in digestion. The acetic acid in ACV can help improve digestion by increasing the production of stomach acid, which is essential for breaking down food and absorbing nutrients. This can be especially helpful for those on a ketogenic diet, as it can improve nutrient absorption and support overall gut health.

In addition to its effects on blood sugar and digestion, ACV may also help boost metabolism. Some studies have shown that ACV can increase the body’s metabolic rate, which can lead to greater fat burning and weight loss. When combined with the fat-burning effects of ketosis, ACV can further enhance weight loss results.

How to Incorporate ACV into Your Ketogenic Diet

There are several ways to incorporate ACV into your ketogenic diet. One of the most popular methods is to mix a tablespoon of ACV with water and drink it before meals. This can help improve digestion and blood sugar regulation, making it easier to stay in ketosis. Some people also like to add ACV to salad dressings or marinades to reap its benefits while adding flavor to their meals.

Another way to incorporate ACV into your ketogenic diet is to use it as a natural remedy for keto flu symptoms. The electrolytes in ACV can help alleviate symptoms like fatigue, headaches, and muscle cramps that are common when transitioning into ketosis. By drinking a diluted ACV solution, you can support your body during this adjustment period.

It’s important to note that while ACV can be a beneficial addition to a ketogenic diet, it should be consumed in moderation. Excessive intake of ACV can lead to tooth enamel erosion and digestive issues. It’s best to start with a small amount and gradually increase your intake as needed, while monitoring how your body responds.

FAQ

Q: Can I take ACV supplements instead of liquid ACV?

A: While ACV supplements can be convenient, they may not be as effective as liquid ACV. The live enzymes and probiotics in liquid ACV are believed to be more beneficial for digestion and overall health. If you choose to take supplements, make sure to do your research and choose a high-quality product.

Q: How soon will I see results from combining ACV with a ketogenic diet?

A: Results may vary depending on the individual, but some people report seeing benefits within a few weeks of incorporating ACV into their ketogenic lifestyle. Consistency is key, so make sure to follow your ketogenic diet and ACV routine regularly to see the best results.

Q: Are there any side effects of taking ACV on a ketogenic diet?

A: Some people may experience digestive discomfort or an upset stomach when first starting ACV. To minimize side effects, start with a small amount of ACV and gradually increase your intake. If you experience persistent side effects, it’s best to consult with a healthcare professional.

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