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GLP-1 agonists have been a breakthrough for the treatment of obesity, a global problem with serious health risks. While the benefits of these therapies are seen as outweighing the risks, there have been some concerns about the loss of muscle mass, particularly in older people using these drugs. iBio is developing next-generation obesity therapies that may be able to be used in combination with GLP-1 agonists or by themselves. Its lead experimental therapy is a myostatin inhibitor, part of a class of therapies that have been of interest to treat muscle wasting. We spoke to Martin Brenner, CEO and chief scientific officer of iBIO, about obesity, the limits of GLP-1 agonists, and the potential for myostatin inhibitors alone or in combination with GLP-1 agonists.

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North Carolina's state health plan will deny coverage of some GLP-1 weight loss drugs, including Novo Nordisk's (NVO) Wegovy and Ozempic, and Eli Lilly's (LLY) Mounjaro. The state claims the drugs are too expensive to cover. University of Pennsylvania Vice Provost for Global Initiatives Dr. Ezekiel Emanuel joins Yahoo Finance' Julie Hyman and Josh Lipton to discuss why he feels the drugs are cost-effective for certain patients, and offers strategies for the state to pay for the coverage. Emanuel explains how North Carolina State health officials advanced a limited view of cost-effectiveness: "If you look at the cost-effectiveness analyses of these drugs for patients who have obesity, they're cost effective. They, in fact, meet [the executive director of the health plan's] criteria, and they do a lot of good for patients who have obesity. Not only do they reduce weight, they also reduce their risk of cardiovascular disease by 20% in the first year. So, they meet his standard of cost-effectiveness. He did not actually do the calculations and examine whether they're cost-effective or not." #youtube #weightloss #yahoofinance About Yahoo Finance: Yahoo Finance provides free stock ticker data, up-to-date news, portfolio management resources, comprehensive market data, advanced tools, and more information to help you manage your financial life. - Get the latest news and data at finance.yahoo.com - Download the Yahoo Finance app on Apple (https://apple.co/3Rten0R) or Android (https://bit.ly/3t8UnXO) - Follow Yahoo Finance on social: X: http://twitter.com/YahooFinance Instagram: https://www.instagram.com/yahoofinance/?hl=en TikTok: https://www.tiktok.com/@yahoofinance?lang=en Facebook: https://www.facebook.com/yahoofinance/ LinkedIn: https://www.linkedin.com/company/yahoo-finance

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