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Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity. In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. *Guest information* Anurag Singh, MD, PhD Chief Medical Officer at Timeline *Thank you to our sponsor* Timeline: https://tinyurl.com/4npjcvjf Mitopure: https://tinyurl.com/ypfjws2e Research from Timeline: https://tinyurl.com/53p6yjc9 [email protected] *Timeline Discount for New Frontiers Listeners* Timeline is offering Dr. Fitzgerald’s readers a 10% discount on Timeline products. Head on over to https://tinyurl.com/ypfjws2e and use the code KARA10 at the checkout. *Show Notes* Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity: https://tinyurl.com/y3c2ypkw Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55= Years Old: A Randomized Triple-Masked Controlled Clinical Trial - https://https://tinyurl.com/bdzfccr8 Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - https://tinyurl.com/2p9pjpxc Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance - https://tinyurl.com/2jkhmu9w Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis - https://tinyurl.com/mvrjxxsm Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial - https://tinyurl.com/fscfdd85 Study: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans - https://tinyurl.com/mr2hd4ms Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population - https://tinyurl.com/e6npdvyp Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials - https://tinyurl.com/2m2nzd56 Preclinical trial: Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance (ENDURO) - https://tinyurl.com/nhkw2pvc Study: The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome - PubMed (nih.gov) - https://tinyurl.com/mrkk33e5 Study: Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice | PLOS Biology - https://tinyurl.com/3s38vtau Study: Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals - PubMed (nih.gov) - https://tinyurl.com/wdzk3tx7 *DrKF Resources* FxMed Podcast: Beyond Mitochondrial Health: Can Urolithin A Slow Down Aging? - https://tinyurl.com/svzahswu DrKF Blog: Beyond Beauty: Targeting Skin Longevity with Urolithin A - https://tinyurl.com/5n6zfu9s DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Bio Age Lab Test: https://tinyurl.com/b7bjmfj9 Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
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A weight loss calculator can help you estimate how many calories you need to consume each day to achieve your weight loss goals. Here's an example of how to use a weight loss calculator: Determine your current weight: Start by weighing yourself on a scale. Determine your goal weight: Decide how much weight you want to lose. For example, if you want to lose 10 pounds, your goal weight would be 10 pounds less than your current weight. Determine your activity level: Are you sedentary, lightly active, moderately active, or very active? This will help you determine your daily calorie needs. Use a weight loss calculator: There are many weight loss calculators available online, including those that factor in your age, height, and gender. Simply enter your information and the calculator will estimate how many calories you need to consume each day to reach your weight loss goal. Keep in mind that weight loss calculators are estimates, and you may need to adjust your calorie intake based on your individual needs and preferences. It's also important to remember that weight loss should be gradual and sustainable, with a goal of losing 1-2 pounds per week. Consult with a healthcare professional before starting any weight loss program.
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Transformative Journey: Eva Marcille’s Weight Loss Story
Eva Marcille, well-known for her modeling career and role in reality television, recently captured the public’s attention with her remarkable weight loss journey. She underwent a dramatic transformation, shedding 100 pounds, which profoundly impacted her life and well-being. This inspiring change did not occur in a vacuum; rather, it was propelled by several life events, including a challenging divorce and the subsequent battle with depression. These personal struggles became the catalyst for a healthier lifestyle that ultimately led to not just physical transformation but emotional and mental rejuvenation as well.
This journey is more than just about losing weight; it reflects Eva’s quest for self-empowerment and resilience. Her experiences highlight the intricate relationship between mental health, personal challenges, and physical form. After facing the heartache of separation from her partner, Eva sought solace in a new lifestyle that demanded changes in her diet, exercise routine, and overall mindset. It is a tale of rediscovering herself and reclaiming ownership over her body and mental state. As she recounts her inspiring story, Eva also offers insight into how societal standards of beauty can sometimes adversely affect one’s self-esteem and motivation.
The narrative of Eva’s weight loss is interwoven with themes of struggle and triumph. Despite facing the emotional burden of divorce, Eva did not allow sadness to define her. Instead, she utilized it as a driving force to make significant lifestyle changes. Through a rigorous exercise regimen and a commitment to healthier eating, she learned to cope with her feelings and channel her experiences into a positive, life-affirming journey. As her body transformed, so did her outlook on life, illustrating the powerful connection between mental health and physical well-being. Through this article, we explore the key aspects of her remarkable transformation, the lessons learned along the way, and the impact it has had on her life and those around her.
Facing the Storm: Divorce and Its Aftermath
Eva’s journey towards self-improvement began during one of the most challenging phases of her life—her divorce. This significant change took a toll on her emotional and mental state, leading to a period of deep reflection and soul-searching. Divorce can significantly impact one’s identity and self-worth, and for Eva, it was no different. The situation forced her to confront feelings of loss, loneliness, and uncertainty about her future. As the initial shock settled, it became evident that this emotional turmoil needed a constructive outlet, which set the stage for her transformation.
In the aftermath of the divorce, Eva found herself grappling with feelings of depression, a common reaction to the end of a long-term relationship. The struggle to cope with these emotions was daunting, but it also sparked a desire for change. Recognizing that she could either succumb to despair or take control of her narrative, Eva chose the latter. She began to acknowledge how her emotional state impacted her physical health. This realization was pivotal; she understood that to heal from the inside out, a holistic approach encompassing both mind and body was necessary.
Through therapy and self-care practices, she learned how to manage her emotions better. She surrounded herself with a supportive network of friends and family, which was crucial during this phase. The journey to recovery involved tackling not only the emotional scars left by her divorce but also the physical manifestations of her emotional pain. The decision to embark on a weight loss journey was as much about healing as it was about aesthetics. It marked the beginning of her commitment to self-acceptance, confidence, and ultimately, a framework that would guide her to a healthier lifestyle.
A Newfound Commitment to Health
With a clear intention to change her life, Eva turned her focus to building a healthier lifestyle. This commitment involved reevaluating her eating habits, which had been neglected during her turbulent emotional period. Understanding that food directly influences both physical and mental health, she set out to nourish her body with wholesome and nutritious meals. This included researching dietary options, consulting nutritionists, and creating well-balanced meal plans tailored to her needs and lifestyle. Eva realized that her relationship with food needed a significant overhaul, moving from comfort eating to mindful consumption.
In conjunction with dietary changes, Eva incorporated regular exercise into her daily routine. Although initially daunting, she approached fitness as a new form of self-expression and empowerment. She explored various forms of exercise, from high-intensity workouts to yoga, eventually discovering a love for activities that not only improved her physique but also uplifted her spirit. This multifaceted approach to fitness not only supported her weight loss goals but also allowed her to cope with stress and anxiety, further attesting to the positive relationship between physical activity and mental well-being.
As her dedication to a healthier lifestyle grew, so did Eva’s confidence. The weight loss was evident, but the most significant transformation was her renewed self-esteem and belief in her capabilities. Each workout session became a victory, and every nutritious meal was a step towards reclaiming her health. This journey taught her invaluable lessons about discipline, self-love, and the importance of setting realistic goals. Eva became an advocate for a balanced approach to health, encouraging others to embrace their journeys with patience and kindness.
Overcoming Challenges in the Journey
Every transformational journey comes with its share of challenges, and for Eva, this was no exception. As she dedicated herself to a healthier lifestyle, she faced obstacles that tested her resolve. Integrating consistent exercise and healthy eating into her daily routine required immense discipline and sometimes meant sacrificing social events and traditional comfort foods. Initially, juggling her responsibilities with this new lifestyle proved challenging and often led to feelings of frustration and doubt. However, Eva learned that setbacks were not failures but opportunities for growth.
Confronting self-doubt became a significant aspect of her journey. As Eva experienced changes in her body, she sometimes grappled with body image issues. Despite the progress she saw, the internal dialogue often focused on her perceived flaws. To combat this negativity, she focused on celebrating her achievements, no matter how small. Surrounding herself with positive influences proved essential. She connected with a community of people on similar journeys, which provided mutual support and motivation.
Through these challenges, Eva emerged stronger and more resilient. Ultimately, she embraced the notion that transformation is not solely a physical endeavor but also a mental and emotional process. Eva’s journey underscored the significance of perseverance and the power of positive thinking. Each struggle reinforced her determination to stay committed to her goals, proving that the path to self-improvement is often laden with tests that forge character and resolve.

Inspiring Others Through Her Story
Eva Marcille’s weight loss journey has inspired countless individuals seeking encouragement on their paths toward health and self-acceptance. As she shared her experiences publicly, she became a beacon of hope for those facing similar struggles. By documenting her transformation through social media, interviews, and public appearances, Eva fostered a community of support, where sharing stories became a therapeutic experience for both her and her followers. Her efforts to remain transparent about her challenges made her relatable and accessible to those who may feel overwhelmed by their circumstances.
Sharing her story also illuminated broader issues related to body image and mental health—conversations that are often stigmatized or overlooked. Eva emphasized that self-acceptance is an ongoing journey, marked by highs and lows. By advocating for mental wellness alongside physical fitness, she underscored the importance of nurturing one’s entire being. This approach resonated with many, encouraging individuals to view health from a holistic perspective.
Through her endeavors, Eva became an influential figure, demonstrating the capacity for change, resilience, and the importance of prioritizing oneself. While her 100-pound weight loss is a significant accomplishment, the true essence of her journey lies in her ability to inspire others to embark on their own quests for self-improvement. Her message is clear: the journey may be challenging, but empowerment through healthy living and emotional resilience is profoundly transformative.
Reflections on a Transformative Experience
Eva Marcille’s remarkable weight loss journey serves as a poignant reminder that personal transformation is achievable, especially when supported by a holistic approach to health and wellness. As we reflect on the key elements of her story, we recognize the interconnectedness of emotional, mental, and physical aspects in achieving significant life changes. The impact of her divorce and subsequent depression was immense, yet it led her to seek a healthier existence, illustrating the complex pathways that life often presents.
Through Eva’s experiences, we learn about the profound benefits of seeking support—whether through friends, family, or community—as we navigate the challenges of self-improvement. Her journey encourages countless individuals to reframe their narratives, highlighting the importance of embracing personal struggles and transforming them into catalysts for change. She exemplifies that the road to health is not linear; it involves setbacks, perseverance, and the continual need for self-compassion.
Lastly, we can take away the message of empowerment from Eva’s journey. By accepting where one is while striving for change, individuals can cultivate a positive and meaningful life. Whether through weight loss, mental health improvement, or simply finding a deeper sense of self-worth, Eva’s story is a testament to the resilience of the human spirit. It is a reminder that with commitment, the right mindset, and support, anyone can embark on their transformative journeys.
Common Inquiries: Understanding Eva’s Journey
Eva Marcille’s journey of weight loss and self-discovery prompts many questions from those inspired by her story. A common inquiry revolves around the specific strategies she implemented to achieve such dramatic results. Many wonder whether she followed a particular diet plan or if she had a dedicated trainer. While Eva incorporated a balanced diet focused on whole foods and regular exercise, the essence of her success lay in her commitment to long-term health rather than temporary diets.
Another frequent question pertains to the emotional challenges Eva faced. How did she stay motivated during difficult times? Eva has frequently emphasized the importance of surrounding oneself with supportive individuals. She recognized that her journey was not just about losing weight but also involved cultivating emotional resilience, which she achieved through therapy and companionship from those who understood her struggles.
<pMany are curious if Eva's transformation was met with societal pressures or criticism. In her journey towards self-acceptance, she often addressed the societal standards of beauty that can create unrealistic expectations. Eva advocates for self-love and acceptance, encouraging others to appreciate their unique journeys rather than conforming to a standard defined by others. Her emphasis on authenticity over perfection holds significant weight in her narrative and serves as a guiding principle for those seeking to reinvent themselves. Overall, Eva Marcille's journey is not just about weight loss; it is about embracing life with courage, strength, and an unwavering belief in oneself.
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🏋🏽♂️I help Busy Professionals❗️ 🔥SHRED 30 lbs, get Abs & KEEP Them ‼️ Instagram: @iamshawnenrique TimewithShawn.com What I’d Do If I Wanted to Lose Body Fat FAST 🔥 If I were starting today, here’s exactly what I’d do to burn fat efficiently and keep it off: 1️⃣ Set a Calorie Deficit 🍳: I’d calculate my daily calorie needs and eat 300-500 calories below maintenance. No crash diets—just sustainable fat loss. 2️⃣ Increase Protein 🍗: At least 1g of protein per lb of body weight to build muscle, stay full, and boost my metabolism. 3️⃣ Strength Train 4-5 Days a Week 🏋️: Focus on compound lifts and progressive overload to build muscle and burn fat all over. 4️⃣ Do Cardio After Workouts 🏃♂️: 30-45 minutes, 5 days a week, either fasted or after lifting, to torch extra calories. 5️⃣ Drink More Water 💧: Stay hydrated to curb cravings and optimize performance. 6️⃣ Track Everything 📱: Calories, macros, workouts—it all gets logged to ensure I’m staying on track. 7️⃣ Stay Consistent 🔁: Fat loss doesn’t happen overnight, so I’d trust the process and stick with it, even when progress feels slow. This is the blueprint that works. Want help getting started? Drop SHRED in the comments, and I’ll send you my free fat loss system to help you crush your goals. Let’s make it happen! 🚀
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