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Dr. Bikman’s Metabolic Classroom lecture this week explores peptides and their effects on metabolism, fat loss, muscle growth, and overall health. Ben begins by defining peptides as short chains of amino acids that act as signaling molecules in the body. While some peptides occur naturally, others are synthetically developed for therapeutic purposes. He explains that peptides are gaining popularity in fitness, anti-aging, and metabolic health, influencing fat loss, muscle repair, insulin sensitivity, and even skin regeneration. He also introduces collagen peptides, highlighting their unexpected metabolic benefits, including their influence on GLP-1 and gut microbiome health. Ben then categorizes peptides based on their primary functions. For fat loss, peptides like CJC-1295 and Tesamorelin work by stimulating growth hormone and IGF-1, promoting fat breakdown while preserving muscle mass. Another peptide, Melanotan-2, originally known for increasing melanin, has been found to suppress appetite by affecting the melanocortin system. He also discusses peptides like Ipamorelin, which help enhance muscle recovery and growth by selectively increasing growth hormone secretion without affecting other pituitary hormones. In the anti-aging and skin health category, Thymosin Beta-4 stands out for its ability to enhance wound healing and tissue repair. Dr. Bikman also highlights the unexpected metabolic role of collagen peptides, explaining how they can increase GLP-1 levels, improve insulin sensitivity, and even activate AMPK, a crucial metabolic regulator involved in fat breakdown and cellular repair. Finally, he touches on how peptides are administered—most commonly via subcutaneous injections, though some peptides can be absorbed sublingually or applied topically. He cautions that not all peptides are created equal, warning against low-quality or counterfeit products. Ben emphasizes the need for high-quality sourcing and careful monitoring, as some peptides affect hormone levels and require medical supervision. Dr. Bikman concludes that peptides hold immense potential for metabolic health, fitness, and longevity, but should be used wisely and responsibly. Show Notes/References: For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more about becoming an Insider on our website: https://www.benbikman.com (Auto-Translate Note: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) #Peptides #MetabolicHealth #FatLoss #MuscleGrowth #CollagenPeptides #InsulinResistance #Hormones #GrowthHormone #CJC1295 #Tesamorelin #Ipamorelin #AntiAging #SkinHealth #Longevity #DrBenBikman #MetabolicScience #GLP1 #MuscleRecovery #GutHealth #PeptideTherapy Timestamps (approximate): 00:01 - Introduction: What Are Peptides & Why Do They Matter? 02:07 - How Peptides Influence Metabolism & Fat Loss 04:26 - Growth Hormone & Fat-Burning Peptides (CJC-1295, Tesamorelin) 06:44 - Melanotan-2: Appetite Suppression & Metabolic Effects 08:52 - Muscle Growth & Recovery Peptides (BPC-157, Ipamorelin) 12:25 - Peptides for Skin Health, Anti-Aging & Wound Healing 14:43 - The Unexpected Metabolic Benefits of Collagen Peptides 17:41 - How Peptides Are Administered: Injections, Sublingual, Topical 20:24 - Safety Considerations: Quality, Sourcing, & Monitoring 21:36 - The Future of Peptides in Metabolic Health & Longevity Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: BEN10) Ben’s favorite dress shirts and pants: https://toughapparel.com/?ref=40 (use BEN10 for 10% off) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd Learn more about becoming an Insider on our website: https://www.benbikman.com

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Explore the highlights of Navigating the Precision Era of Obesity Management with Next-Generation Pharmacotherapy, Endocrine Insights, and Tailored Guidelines, a 2025 deep-dive into how advanced weight loss medications, hormonal understanding, and updated treatment algorithms are transforming patient care. This comprehensive review examines breakthrough pharmacotherapies like dual incretin receptor agonists, the role of endocrine factors, and the evolving criteria for bariatric surgery—empowering healthcare professionals with cutting-edge insights to deliver more personalized, effective obesity management. Discover doctor-approved health tips for fitness and preventing illness with Hidoc Dr.! Access the detailed article here: https://hidocdr.com/articles/b699da58-ede1-441d-8655-69ea95ab8bcc #ObesityManagement2025 #PrecisionMedicine #Pharmacotherapy #EndocrineInsights #HidocDr #HealthTips #StayHealthy #HealthCare #MedicalTips #Wellness #HealthyLiving #FitnessAndHealth #HealthyLifestyle #HealthAwareness #patienteducation

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00:00 - Managing Side Effects of GLP-1 Medications: Nutrition & Activity Tips 07:11 - GLP-1 Weight Loss Secrets: Expert-Backed Diet & Exercise Guide 16:25 - Balancing Weight Loss & Muscle Preservation in GLP1 Receptor Agonist Therapy 1. Managing Side Effects of GLP-1 Medications: Nutrition & Activity Tips In this video, we explore essential nutrition and activity guidance for patients using GLP-1 medications like Wegovy, Ozempic, and Mounjaro. Learn how to mitigate side effects, preserve muscle mass, and prevent nutritional deficiencies while on these weight-loss medications. We discuss the importance of tailored dietary plans, protein intake, and physical activity recommendations to support your health journey. Discover practical strategies for monitoring weight, assessing nutritional needs, and maintaining muscle strength. Join us for expert insights and tips to enhance your experience with GLP-1 therapies! 2. GLP-1 Weight Loss Secrets: Expert-Backed Diet & Exercise Guide Learn how to maximize GLP-1 medication results with expert-proven diet and exercise strategies. In this video: 🔥 Discover the 3-step exercise plan to boost metabolism 數 Find out the critical protein intake to prevent muscle loss 濫 Learn side effect management for nausea/reflux ⚖️ Understand why weight regain happens (and how to prevent it) GLP-1 medications like Ozempic/Mounjaro work best when combined with tailored nutrition and physical activity. Harvard experts explain: - How to track weight loss safely - Nutrition tips for sustainable results - Why resistance training matters - Long-term management strategies Perfect for anyone on GLP-1 medication seeking optimized results. 3. Balancing Weight Loss & Muscle Preservation in GLP1 Receptor Agonist Therapy Explore the latest research on GLP1 receptor agonists and their impact on weight and muscle loss. This video delves into the emerging evidence and clinical strategies to prioritize muscle preservation, ensuring long-term success and safety in pharmacological weight management. Discover how to balance effective weight loss with maintaining crucial muscle mass for better metabolic and functional outcomes. #GLP1Therapy #WeightLoss #MusclePreservation #Endocrinology

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Support My Channel By Becoming A Member! https://www.youtube.com/channel/UCClsXzSiGOe--bWN3kGs6gQ/join 👉 W A T C H N E X T : 🤸🏽‍♀️ My Weight Loss Journey https://www.youtube.com/playlist?list=PLj9B-nQnayiw3826M1CXID3xxTKsyI7bP GLP-1 Playlist https://www.youtube.com/playlist?list=PLj9B-nQnayiz5Xl-n3um3o3C1N1KhCBV9 -----------------------------------------