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From diabetes to obesity and beyond --- In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion. --- Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future. --- For more on how Springer Medicine can tailor medical education to meet your needs, head to https://go.sn.pub/visit-smed and register for updates.

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Revolutionizing Obesity Treatment: Connecticut's Bold Move and Pharma's Power Plays In this episode of The Downsize News, dated Monday, July 14th, hosts Laraine and Christopher Durham delve into groundbreaking developments in the world of GLP-1 medications, which have significantly impacted their personal weight loss journeys. They start with Connecticut's recent legislative move to manufacture generic versions of GLP-1 drugs, pending federal approval, aimed at reducing costs and expanding access. This could set a precedent for states like California, Louisiana, Washington, North Carolina, West Virginia, and Pennsylvania amidst skyrocketing GLP-1 expenditures. Next, Novo Nordisk's aggressive marketing campaign for Wegovy during the NBA finals is highlighted, alongside this pharmaceutical giant's bid for a higher dose approval in Europe. This newer dose has shown substantial promise in clinical trials, potentially signaling further advancements for US markets. Eli Lilly, in a defensive maneuver, is increasing its US imports from Ireland to buffer against potential trade disruptions, illustrating the global implications of GLP-1 drug production and distribution. Additionally, Novo Nordisk's $2.3 billion investment in Italian manufacturing marks its effort to maintain a competitive edge in the European market. Other stories include promising preclinical studies on the new combination drug Cagrisema, which merges amylin analog with Semaglutide, showing enhanced weight loss mechanisms that counter normal metabolic adaptation. Kate Farms' introduction of a new high-protein, zero-sugar nutritional shake and Ipsos' innovative 'GLP-1 Persona Bot' for better consumer insights underscore the market's evolving landscape. Eli Lilly's donation of a mobile clean room lab to Purdue University aims to train future professionals in sterile compounding, crucial for advancing pharmaceutical manufacturing. The episode wraps up with the Durhams urging viewers to visit their Amazon store for curated GLP-1 user products, supporting both their channel and the weight loss journey of their community. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store As an Amazon Associate I earn from qualifying purchases. DOWNSIZED WEBSITE: https://thedownsized.org/ BOOK THE DOWNSIZED AT SEA CRUISE 2026: https://thedownsized.org/downsized-at-sea-2026/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Overview 01:18 Connecticut's Bold Move on GLP-1 Generics 06:34 Novo Nordisk's Wegovy Ad Blitz 10:21 Novo Nordisk Submits Higher Dose Wegovy to EU 13:03 Eli Lilly's Strategic Moves 15:13 Novo Nordisk's Expansion in Italy 16:53 Preclinical Study on Cagrisema and Weight Loss 20:07 Novo Nordisk's Investment in China 23:03 Kate Farms' New High-Protein Shake 23:59 Ipsos' GLP-1 Persona Bot 26:11 Eli Lilly's Mobile Clean Room Lab Donation 27:41 Conclusion and Final Thoughts

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In this episode of Girls Gone Gritty, the hosts take on some of the most buzzworthy and hard-hitting topics of the week. They start with a deep dive into the growing popularity of weight loss drugs like Ozempic, questioning whether these GLP-1 medications are truly revolutionary or just another health trend with risks no one is talking about. They also examine the bigger picture—how the food and pharmaceutical industries might be fueling the obesity crisis, making it less about personal choices and more about what’s being offered to the public. The hosts also shed light on the surprising reality of plastic in our bodies—how it’s getting there and what it could mean for long-term health. As always, this episode features the Top 5 Grittiest Headlines of the Week, covering everything from a kayaker who was swallowed (and miraculously spit out) by a whale to intense brawls at a USA vs. Canada hockey game and shocking airline mishaps. To wrap things up, the hosts share the inspiring story of Ali Truwit, a former Yale swimmer who turned a personal tragedy into a powerful movement, working to make prosthetics more accessible for amputees. Episode Highlights: (0:00) Intro (3:20) Top 5 grittiest headlines of the week (13:10) Are weight loss drugs the real deal or just another fad? (18:35) Health benefits vs. long-term risks of GLP-1 drugs (23:52) Farley’s personal experience with Ozempic & the side effects (29:59) The hidden cost of weight loss drugs & America’s obesity problem (34:02) Got Grit Winner: Ali Truwit’s inspiring journey & mission (39:52) Outro Follow us: Web: https://girlsgonegritty.com/ Instagram: https://www.instagram.com/girlsgonegritty/ More ways to find us: https://linktr.ee/girlsgonegritty

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