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New weight-loss jabs could get people "back into work" to boost the economy, the prime minister has said. Sir Keir Starmer said injections could also help reduce pressure on the NHS. Health Secretary Wes Streeting has suggested the jabs could be given to unemployed people to help them return to the workplace. #labourn #weightloss #keirstarmer Read more: https://news.sky.com/story/weight-loss-jabs-could-get-people-back-into-work-to-boost-economy-starmer-says-13233876 SUBSCRIBE to our YouTube channel for more videos: http://www.youtube.com/skynews Follow us on Twitter: https://twitter.com/skynews Like us on Facebook: https://www.facebook.com/skynews Follow us on Instagram: https://www.instagram.com/skynews Follow us on TikTok: https://www.tiktok.com/@skynews For more content go to http://news.sky.com and download our apps: Apple https://itunes.apple.com/gb/app/sky-news/id316391924?mt=8 Android https://play.google.com/store/apps/details?id=com.bskyb.skynews.android&hl=en_GB Sky News Daily podcast is available for free here: https://podfollow.com/skynewsdaily/ Sky News videos are now available in Spanish here/Los video de Sky News están disponibles en español aquí: https://www.youtube.com/channel/UCzG5BnqHO8oNlrPDW9CYJog To enquire about licensing Sky News content, you can find more information here: https://news.sky.com/info/library-sales

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Lesley Stahl reports on how obesity is misunderstood, and the struggle to get new weight loss drugs to people who need them. #60Minutes #News #WeightLoss "60 Minutes" is the most successful television broadcast in history. Offering hard-hitting investigative reports, interviews, feature segments and profiles of people in the news, the broadcast began in 1968 and is still a hit, over 50 seasons later, regularly making Nielsen's Top 10. Subscribe to the “60 Minutes” YouTube channel: http://bit.ly/1S7CLRu Watch full episodes: http://cbsn.ws/1Qkjo1F Get more “60 Minutes” from “60 Minutes: Overtime”: http://cbsn.ws/1KG3sdr Follow “60 Minutes” on Instagram: http://bit.ly/23Xv8Ry Like “60 Minutes” on Facebook: http://on.fb.me/1Xb1Dao Follow “60 Minutes” on Twitter: http://bit.ly/1KxUsqX Subscribe to our newsletter: http://cbsn.ws/1RqHw7T Download the CBS News app: http://cbsn.ws/1Xb1WC8 Try Paramount+ free: https://bit.ly/2OiW1kZ For video licensing inquiries, contact: [email protected]

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Metformin is the first-line medication for type 2 diabetes in over 80 percent of global endocrinology guidelines. Evidence: International Diabetes Federation and American Diabetes Association both recommend it as first choice for new diagnoses. About 60 percent of people who take metformin experience weight loss, averaging 3.5 to 4 kilograms (around 8 pounds) per year. Evidence: Multiple meta-analyses (e.g., Diabetes Obes Metab, 2018) show this effect in both diabetics and people with prediabetes or PCOS. Metformin is linked to a lower risk of certain cancers, especially in people with diabetes. Evidence: Studies suggest a 10–40 percent reduction in risk for some cancers (like colon, breast, prostate), but evidence is mixed and not yet conclusive for non-diabetics. Metformin acts mainly by reducing glucose production in the liver (gluconeogenesis), activating the AMPK pathway. AMPK is a central energy sensor, signaling the body to burn fat and save energy. This is a well-documented, universal mechanism in all users. Metformin increases fat burning and improves insulin sensitivity, making it effective for both weight loss and improving blood sugar control. Evidence: Consistent findings in both clinical trials and real-world practice. More than 30 percent of metformin users experience mild gastrointestinal side effects (nausea, bloating, diarrhea), but only about 5 percent stop due to these effects. Evidence: Meta-analyses, e.g., in Diabetes Care, confirm these percentages. Long-term metformin use causes vitamin B12 deficiency in about 5–10 percent of users. Recommendation: Regular B12 monitoring every 2–3 years if on long-term therapy. Supplementation can fully correct the deficiency. Metformin is not recommended for people with severe kidney, liver, or heart failure due to the risk of lactic acidosis (extremely rare—much less than 1 percent if kidneys are normal). Metformin may extend lifespan in animals by about 10 percent. Evidence: Animal studies show this reliably. The TAME trial (for humans) is ongoing, with results expected in 2026. Metformin is frequently used “off-label” in people without diabetes (e.g., prediabetes, PCOS), but current guidelines do not recommend it for weight loss in healthy people due to limited long-term safety data in this group. Disclaimer: This information is provided for general knowledge and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always consult with your doctor for any questions or concerns you may have about your health.