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Become a member to watch the full episode, plus gain immediate access to our entire back catalog of AMA episodes! Subscribe now: https://bit.ly/3Hfq0kV In this “Ask Me Anything” (AMA) episode, Peter and Bob discuss all things related to GLP-1 agonists—a class of drugs that are gaining popularity for the treatment of obesity. They cover the discovery of these peptides, their physiology, and what it is they do in their natural state. Next, Peter and Bob break down a recently published study which showed remarkable results for weight loss and other metabolic parameters using a once-weekly injection of the GLP-1 agonist drug semaglutide, also known as Ozempic, in overweight and obese patients. Finally, they compare results from the semaglutide study to results from various lifestyle interventions and give their take on the potential future of GLP-1 agonists. In this sneak peek, we discuss: 00:00 - Intro 00:10 - Remarkable results of a recent study in overweight adults 02:15 - Key background on insulin, glucagon and the incretin effect to appreciate the effects of semaglutide In the full episode, we also discuss: -What is GLP-1 and how does it work? -2021 semaglutide study: remarkable results, side effects, and open questions; -Semaglutide vs. lifestyle interventions: comparing results with semaglutide vs. lifestyle interventions alone; -Closing thoughts and open questions on the therapeutic potential of semaglutide; and -More. Read the show notes for this episode here: https://bit.ly/3nbZYac -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 35 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://bit.ly/3kBNdUG Subscribe to receive exclusive subscriber-only content: https://bit.ly/3Hfq0kV Sign up to receive Peter's email newsletter: https://bit.ly/30mqvII Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle

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10 Tips for Losing Weight While Breastfeeding Website: http://www.twelveweeks.iblogger.org Blog: http://www.twelveweekstome.blogspot.com Number One: Wait Wait until your baby is at least 2 months old before trying to lose weight to ensure that your milk supply is established. Number Two:Exercise Start lightly, exercising 10-15 minutes 3-5 days a week and gradually increase from there. Number Three: Hydrate Drink a full glass of water one hour before working out, and one hour after, and during. Also, try to drink at least 8 glasses a day. Number Four:Don't Starve Yourself Eat 5-6 small meals a day and try to consume 1800-2000 Calories each day. Number Five: Take it Slow Try not to lose more than 1.5 to 2 lbs a week, because losing too quickly is unsafe for your body and poses a risk of jeopardizing your milk supply. Number Six: Take a Day Off Take a day off to nurse your baby frequently and as much as possible to reestablish your milk supply. Number Seven: Rest Rest is key to losing weight because when you're tired your body releases stress hormones like cortisol, which causes your body to retain fat. Number Eight: Don't Diet Instead of trying a fad diet, try eating healthily because dieting only leaves room for falling off the wagon, more than changing your eating lifestyle. Number Nine: Stick to fruits & veggies Grab an orange or an apple instead of a cookie, and try to include a veggie with every meal. Number Ten: Clean up Shower or use wipes to clean yourself off after working out because babies don't like the salty taste that is left behind.

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The weight loss medication market is constantly evolving, with new drugs being developed to help individuals achieve their weight loss goals. Semaglutide and tirzepatide are two medications that have gained attention for their potential to aid in weight loss. Both drugs belong to the class of glucagon-like peptide-1 (GLP-1) receptor agonists, which have been shown to be effective in helping individuals lose weight. In this article, we will compare semaglutide vs tirzepatide for weight loss, examining their effectiveness, side effects, and other factors to consider when choosing between the two medications.

Effectiveness

Semaglutide has been studied extensively in clinical trials for its effectiveness in promoting weight loss. In a study published in the New England Journal of Medicine, researchers found that individuals taking semaglutide lost significantly more weight compared to those taking a placebo. The average weight loss among participants taking semaglutide was around 15% of their body weight, making it one of the most effective weight loss medications currently available.

On the other hand, tirzepatide is a newer medication that is also showing promise in promoting weight loss. In a recent study published in the Lancet, researchers found that individuals taking tirzepatide lost an average of 12% of their body weight over a 40-week period. While not as potent as semaglutide, tirzepatide still offers a significant amount of weight loss for individuals struggling to lose weight through diet and exercise alone.

Overall, both semaglutide and tirzepatide have been shown to be effective in promoting weight loss. However, semaglutide may offer slightly greater weight loss results compared to tirzepatide.





Side Effects

Like all medications, semaglutide and tirzepatide can cause side effects in some individuals. The most common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to improve over time as the body adjusts to the medication.

Similarly, tirzepatide can also cause gastrointestinal side effects such as nausea, vomiting, and diarrhea. In addition, tirzepatide has been associated with an increased risk of hypoglycemia (low blood sugar) in individuals with diabetes. It is important for individuals taking tirzepatide to monitor their blood sugar levels closely and talk to their healthcare provider if they experience any symptoms of hypoglycemia.

Overall, both semaglutide and tirzepatide have similar side effect profiles, with gastrointestinal issues being the most commonly reported side effects. It is important for individuals considering these medications to discuss the potential side effects with their healthcare provider before starting treatment.

Cost

Another factor to consider when comparing semaglutide vs tirzepatide for weight loss is the cost of the medications. Semaglutide is currently available as a brand-name medication, Ozempic, which can be expensive for individuals without insurance coverage. However, a generic version of semaglutide is expected to become available in the near future, which may help reduce the cost of the medication for some individuals.

On the other hand, tirzepatide is also a brand-name medication and may be expensive for individuals without insurance coverage. The cost of tirzepatide may vary depending on the dosage and frequency of administration prescribed by a healthcare provider. It is important for individuals considering tirzepatide to check with their insurance provider to determine coverage for the medication.

Overall, the cost of semaglutide and tirzepatide may be a deciding factor for some individuals when choosing between the two medications. It is important to consider the cost of the medications in conjunction with their effectiveness and side effects when making a decision.

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00:00 - GLP-1 Drugs for Brain Health? New Study Shows Promise for Dementia & Stroke! 04:21 - GLP-1s vs Metformin: Which Diabetes Medication Offers Better Protection Against Dementia? 1. GLP-1 Drugs for Brain Health? New Study Shows Promise for Dementia & Stroke! In this video, we dive into a groundbreaking study published in JAMA Network Open that explores the potential of GLP-1 agonists, like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), to protect against neurodegenerative diseases. We'll break down the key findings: * Reduced risk of dementia, ischemic stroke, and all-cause mortality in patients using GLP-1 drugs. * The study's limitations and the need for further research. * Exciting developments: Novo Nordisk's Alzheimer's trials (EVOKE and EVOKE Plus) and Lilly's potential use of tirzepatide alongside Kisunla (anti-amyloid antibody). Learn how these medications, primarily used for weight loss and diabetes, might offer significant benefits for brain health. #GLP1 #Semaglutide #Tirzepatide #Dementia #Alzheimers #Stroke #BrainHealth #WeightLoss #Diabetes #Neuroprotection #Ozempic #Wegovy #Mounjaro #Zepbound #NovoNordisk #trump 2. GLP-1s vs Metformin: Which Diabetes Medication Offers Better Protection Against Dementia? A groundbreaking study reveals that GLP-1 receptor agonists may provide superior protection against dementia for type 2 diabetes patients compared to metformin. With nearly two decades of data, this research offers the first direct comparison between these treatments. Join us as we delve into the findings, explore the potential mechanisms, and hear expert opinions. From neuroinflammation to socioeconomic factors, we uncover the factors that could influence the effectiveness of these medications. Don't miss this insightful exploration of diabetes management and dementia prevention.