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GLP-1受容体作動薬およびGIP/GLP-1受容体作動薬について GLP-1(Glucagon-Like Peptide-1)受容体作動薬およびGIP/GLP-1受容体作動薬は主に2型糖尿病の治療に用いられる注射薬および一部経口薬です。 1.作用機序 GLP-1受容体作動薬:膵臓のβ細胞膜上にあるGLP-1受容体に結合し、インクレチンホルモンであるGLP-1の作用を増強します。これにより、以下の効果を発揮します。 ・血糖依存性のインスリン分泌促進:血糖値が高い時にインスリンの分泌を促します。 ・グルカゴン分泌抑制:血糖値を上げる作用のあるグルカゴンの分泌を抑制します。 ・胃内容物排出遅延作用:食後の血糖値の急激な上昇を抑えます。 ・食欲抑制作用:体重減少効果に寄与します。 GIP/GLP-1受容体作動薬(チルゼパチドなど):GLP-1受容体に加え、もう一つのインクレチンホルモンであるGIP(グルコース依存性インスリン分泌刺激ポリペプチド)の受容体にも結合し、両方の作用を増強することで、より強力な血糖降下作用や体重減少作用が期待されます。 2.主な効果と特徴 ・血糖コントロール改善:空腹時血糖値と食後血糖値の両方を低下させます。 ・体重減少効果:食欲抑制作用や胃内容物排出遅延作用により、多くの患者さんで体重の低下が期待できます。 ・低血糖リスク:単独使用では低血糖をきたす可能性は低いです(血糖依存的に作用するため)。 ・心血管・腎保護効果:一部のGLP-1受容体作動薬には、心血管イベントのリスクを低減する効果や、腎症の進行を抑制する効果が大規模臨床試験で示されています。 ・投与方法:多くは皮下注射製剤で、1日1~2回投与のものや週1回投与のものがあります。経口薬(セマグルチド)も利用可能です。 3.主な副作用 ・消化器症状:投与初期に悪心、嘔吐、下痢、便秘などの胃腸障害が比較的多く認められます。多くは一過性ですが、症状が強い場合は医師に相談が必要です。1日1回または2回注射の製剤では、低用量から開始し、徐々に増量することでリスクを軽減します。 ・注射部位反応:注射薬の場合、注射部位に発赤、腫れ、かゆみなどが起こることがあります。 ・急性膵炎:まれですが、急性膵炎の報告があります。持続的な激しい腹痛(嘔吐を伴うこともある)などの初期症状に注意が必要です。 ・胆石症、胆嚢炎:報告があります。 ・甲状腺髄様癌(動物実験での報告):ヒトでの関連は不明ですが、甲状腺髄様癌の既往のある患者さんや家族歴のある患者さんには慎重な投与が考慮されます。 4.使用上の注意点 ・適応:主に2型糖尿病患者さんに用いられ、1型糖尿病やインスリン依存状態の患者さんへの適応はありません。 ・DPP-4阻害薬との併用:作用機序が類似しているため、原則として併用しません。 ・SU薬・インスリンとの併用:低血糖のリスクが増加するため、これらの薬剤の用量を減らすことを検討する必要があります。 ・インスリン治療からの切り替え:インスリン依存状態にないことを確認した上で慎重に行う必要があります。 ・急性膵炎の既往:膵炎の既往のある患者さんには慎重に投与します。急性膵炎の初期症状について患者さんに十分指導しておく必要があります。 ・経口セマグルチドの服用方法:1日のうちの最初の食事または飲水の前に、空腹の状態でコップ約半分の水(約120mL以下)とともに1錠服用し、服用後少なくとも30分は飲食および他の薬剤の経口摂取を避けるなど、多くの留意点があります。 ・GIP/GLP-1受容体作動薬(チルゼパチドなど)の網膜症への影響:急激な血糖コントロールの改善に伴い、糖尿病網膜症が一時的に悪化または顕在化することがあるため、増殖網膜症などを合併する患者さんでは、眼科医と連携し慎重に経過を観察する必要があります。 主な薬剤 GLP-1受容体作動薬(注射薬): ・1日1~2回投与:リラグルチド(販売名:ビクトーザ)など ・週1回投与:デュラグルチド(販売名:トルリシティ)、セマグルチド(販売名:オゼンピック)など GLP-1受容体作動薬(経口薬): ・セマグルチド(販売名:リベルサス) GIP/GLP-1受容体作動薬(注射薬): ・チルゼパチド(販売名:マンジャロ) これらの薬剤は、血糖降下作用に加えて体重減少効果や心血管・腎保護効果も期待できる場合があり、2型糖尿病治療における重要な選択肢となっていますが、消化器症状などの副作用や使用上の注意点をよく理解し、医師の指示に従って適切に使用することが大切です。
Ketogenic Diet Quitting Sugar
Are you on a keto diet but missing your favorite gummy candies? Look no further! In this article, we will explore the best keto gummies on the market. These delicious treats are low in carbs and sugar, making them the perfect guilt-free snack for anyone following a ketogenic lifestyle. Whether you’re craving something sweet or just looking for a convenient way to enjoy your favorite flavors, keto gummies are sure to satisfy your cravings without derailing your diet. Read on to discover our top picks for the best keto gummies available today!
Top Picks for Keto Gummies
1. Kiss My Keto Gummies: These gummies are made with high-quality ingredients such as MCT oil and collagen, making them a great option for anyone looking to boost their energy levels and support their skin health while staying in ketosis. With flavors like raspberry and lemon, these gummies are sure to become a staple in your keto snack arsenal.
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2. Smart Sweets Gummy Bears: If you’re a fan of classic gummy bears, you’ll love these keto-friendly alternatives from Smart Sweets. Made with plant-based ingredients and sweetened with stevia, these gummy bears are low in sugar and high in fiber, making them a satisfying treat that won’t spike your blood sugar levels.
3. ChocZero Keto Bark: For those who prefer chocolate over gummies, ChocZero offers a delicious keto-friendly bark that is perfect for satisfying your sweet tooth. Made with dark chocolate and sweetened with monk fruit extract, this treat is rich in antioxidants and free from artificial ingredients, making it a guilt-free indulgence for any keto dieter.
Additional Recommendations
4. Supa Sweet Gummy Worms: These gummy worms are not only keto-friendly but also gluten-free and made with natural colors and flavors. With a variety of fruity flavors to choose from, these gummies are a fun and tasty way to enjoy a sweet treat while sticking to your keto goals.
5. HighKey Mini Cookies: While not technically gummies, these mini cookies from HighKey offer a delicious and convenient alternative for satisfying your cravings on a keto diet. Made with almond flour and sweetened with erythritol, these cookies are perfect for on-the-go snacking or as a dessert option when you’re in need of a sweet treat.
Whether you’re looking for a fruity gummy snack or a rich chocolate indulgence, there are plenty of keto-friendly options available to satisfy your cravings without compromising your diet. Experiment with different brands and flavors to find your favorites, and enjoy the convenience of having delicious treats on hand that support your ketogenic lifestyle.
Conclusion
In conclusion, keto gummies are a delicious and convenient way to enjoy your favorite flavors without straying from your ketogenic diet. With options ranging from fruity gummies to chocolate treats, there’s something for everyone to enjoy. Give these top picks a try and discover a new favorite snack that will keep you on track with your keto goals while satisfying your sweet tooth.

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Dr. Oz is a well-known TV personality, cardiothoracic surgeon, and professor at Columbia University. He is also a huge fan of the keto diet and frequently talks about its benefits on his show. As a guest on Shark Tank, Dr. Oz shared some of his favorite keto picks with the audience. Let’s take a closer look at these products and why he recommends them for a ketogenic lifestyle.
Perfect Keto
Perfect Keto is a popular brand that offers a wide range of keto-friendly products, including MCT oil, exogenous ketones, and collagen protein. These products are designed to help people on the keto diet reach and maintain ketosis more easily. Dr. Oz recommends Perfect Keto because of the quality of their ingredients and the effectiveness of their products in supporting a ketogenic lifestyle.
One of the standout products from Perfect Keto is their MCT oil powder, which can be added to coffee, smoothies, or recipes to increase fat intake and boost ketone levels. MCTs are a type of fat that is quickly converted into ketones by the liver, making them a valuable addition to a keto diet. Perfect Keto’s MCT oil powder is derived from coconuts and is easy to digest, making it a convenient way to increase fat intake on a ketogenic diet.
In addition to MCT oil powder, Perfect Keto also offers exogenous ketones in the form of supplements or drink mixes. Exogenous ketones can help support ketosis, enhance mental clarity, and provide a quick source of energy for the brain and muscles. Dr. Oz recommends incorporating exogenous ketones into your routine to help you stay on track with your keto goals.
KetoLogic
KetoLogic is another brand that offers a variety of keto products, including meal replacement shakes, supplements, and snacks. These products are designed to make it easier for people to follow a ketogenic diet by providing convenient and delicious options for meals and snacks. Dr. Oz is a fan of KetoLogic because of the company’s commitment to quality and their focus on making keto accessible to everyone.
One of the most popular products from KetoLogic is their meal replacement shakes, which are low in carbs and high in fat and protein. These shakes can be used as a quick and easy meal or snack when you’re on the go and don’t have time to prepare a full meal. Dr. Oz recommends incorporating KetoLogic shakes into your routine to help you stay satisfied and energized while following a ketogenic diet.
In addition to meal replacement shakes, KetoLogic also offers supplements like BHB salts, which can help support ketosis and enhance performance during workouts. BHB salts are a type of exogenous ketone that can be taken to increase ketone levels and provide a quick source of energy. Dr. Oz encourages people on a keto diet to consider trying BHB salts as a way to boost their ketone levels and support their overall health and wellness.
Just Thrive
Just Thrive is a brand that specializes in probiotic supplements designed to support gut health and overall wellness. While not specifically keto products, probiotics can play a beneficial role in a ketogenic diet by helping to maintain a healthy gut microbiome and support digestion. Dr. Oz recommends Just Thrive probiotics as a way to enhance gut health and support your body while following a ketogenic lifestyle.
One of the key benefits of Just Thrive probiotics is their spore-based strains, which are designed to survive the harsh conditions of the gut and reach the intestines where they can colonize and provide benefits. These strains have been shown to support immune function, reduce inflammation, and improve digestion. Dr. Oz believes that incorporating Just Thrive probiotics into your routine can help you feel your best while following a keto diet.
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In addition to probiotics, Just Thrive also offers other supplements like enzymes and antioxidants that can support gut health and overall wellness. These products are designed to work synergistically with probiotics to provide comprehensive support for your digestive system and immune function. Dr. Oz recommends considering Just Thrive supplements as part of your overall wellness plan while following a ketogenic diet.
FBOMB
FBOMB is a brand that specializes in high-quality, convenient fat-fueled snacks that are perfect for people following a ketogenic diet. Dr. Oz recommends FBOMB products because they provide a delicious and convenient way to increase your fat intake and stay satisfied while on a keto diet. These snacks are made with clean ingredients and are designed to help you reach and maintain ketosis more easily.
One of the standout products from FBOMB is their nut butter packets, which come in a variety of delicious flavors like macadamia pecan and salted chocolate. These packets are perfect for on-the-go snacking and can be enjoyed by themselves or paired with other keto-friendly foods. Dr. Oz recommends keeping some FBOMB nut butter packets on hand for when you need a quick and easy way to increase your fat intake on a ketogenic diet.
In addition to nut butter packets, FBOMB also offers other snacks like meat sticks and cheese crisps that are perfect for satisfying hunger and cravings while following a keto diet. These snacks are portable, shelf-stable, and made with high-quality ingredients, making them a convenient option for people on the go. Dr. Oz suggests trying a variety of FBOMB snacks to find your favorites and incorporate them into your keto meal plan.
Power Crunch
Power Crunch is a brand that specializes in protein bars that are perfect for people following a ketogenic diet. Dr. Oz recommends Power Crunch bars because they are low in carbs, high in protein, and delicious, making them an ideal option for a quick and easy snack or meal replacement while on a keto diet. These bars are available in a variety of flavors and are designed to support your protein intake while keeping your carb intake low.
One of the key features of Power Crunch bars is their unique wafer cookie texture, which sets them apart from traditional protein bars. This texture makes them enjoyable to eat and easy to digest, making them a convenient option for people with busy lifestyles. Dr. Oz suggests keeping some Power Crunch bars on hand for when you need a tasty and satisfying snack that fits within your keto plan.
In addition to protein bars, Power Crunch also offers protein powders and shakes that can help you meet your protein needs while following a ketogenic diet. These products are low in carbs, high in protein, and designed to support muscle recovery and growth. Dr. Oz recommends incorporating Power Crunch protein products into your routine to help you stay on track with your keto goals and support your fitness and wellness journey.
Summary and FAQ
In summary, Dr. Oz has shared some of his favorite keto picks with the audience on Shark Tank, including products from brands like Perfect Keto, KetoLogic, Just Thrive, FBOMB, and Power Crunch. These products are designed to support a ketogenic lifestyle by providing convenient, delicious, and high-quality options for meals and snacks. Dr. Oz recommends incorporating these products into your routine to help you reach and maintain ketosis, support your overall health and wellness, and stay on track with your keto goals.
Here are some frequently asked questions about Dr. Oz’s favorite keto picks:
Q: Are these products suitable for beginners on a keto diet?
A: Yes, these products are great for beginners as they provide convenient and delicious options for meals and snacks while following a ketogenic diet. They can help you reach and maintain ketosis more easily and support your overall health and wellness.
Q: Where can I find these products?
A: These products are available online through the respective brand websites or on popular retail sites like Amazon. You can also check your local health food stores for availability.
Q: Are these products affordable?
A: While the prices may vary depending on the product and brand, many of these products offer competitive pricing and value for the quality of ingredients and benefits they provide. It’s always a good idea to compare prices and look for discounts or promotions when purchasing.
Q: Can I use these products in combination with other supplements or medications?
A: It’s always best to consult with a healthcare provider or nutritionist before incorporating new supplements or products into your routine, especially if you are taking other medications or have underlying health conditions. They can provide personalized guidance and ensure that the products are safe and suitable for you.
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