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Paper: https://doi.org/10.1126%2Fscience.adj2537 Chapters 0:00 – Culinary Kryptonite 1:06 – GLP-1 preingestive satiation 2:46 – DMH is the brain region involved in preingestive satiation 4:14 – Heterogeneity: Rainbows and Froot Loops 5:58 – Anti-Responder? 7:13 – There’s always room for ice cream 10:29 – My prescriptions Optogenetics breakdown (go to 3 min 19 sec) in this video: https://youtu.be/44qM9VtNAjc Video Sponsor(s) - House of Macadamia and RxSugar Yes, I’m wearing a Mac Monster Macadamia Nut Shirt! I’ve been a heavy user of highly satiating macadamia nuts for over 5 years since I started a ketogenic diet. They’re delicious, versatile, high MUFA, high Omega-7/Palmitoleic Acid, low Omega-6/Linoleic acid, and low oxalate, phytate and lectin. To try product from my favorite nut company, HouseOfMacadamia, Go To: http://partner.houseofmacadamias.com/nick-norwitz - 15% Off All Bundles - 10% off any item (non-bundle) with code "NICK10" And for more information on macadamia nutrition and Omega-7: https://youtu.be/Vngn6i-rmZI I'm also on the scientific advisory board at RxSugar, a company that specializes in allulose. Unlike macadamia - which I do consume regularly - I don't have much of a sweet tooth so don't find I have much of a need for allulose. However, I always try my best to separate my personal preferences from the science, which is why I'm happy and proud to support RxSugar and their mission to displace fructose and sugar in the food supply with allulose! Among allulose's interesting properties is that it induces the release of endogenous GLP-1, albeit at lower dose equivalencies than prescription medications. Still, there are data (clinical and preclinical) that allulose can have anti-obesogenic properties. And the precise mechanism is being explored actively! There are also clinical reports of people have loss of cravings and "food noise" with allulose products, which is interesting. I wonder if one could measure a change in DMH pre-ingestion satiation neurons after an allulose bolus... perhaps we will find out in time! You can use my discount code NICK20 for 20% off any products. https://rxsugar.com For more scientific information on allulose, go here: https://youtu.be/pr93EsEV2bM

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Semaglutide, a drug traditionally used to treat type 2 diabetes, has recently gained attention for its potential as a weight loss treatment in non-diabetic individuals. This injectable medication works by mimicking the action of a hormone that regulates blood sugar levels and appetite. Studies have shown promising results in terms of weight loss, leading many to consider semaglutide as a potential solution for obesity.

How Does Semaglutide Work for Weight Loss?

Semaglutide works by binding to receptors in the brain that control appetite and food intake. By activating these receptors, the drug can help regulate hunger and reduce cravings, leading to decreased calorie consumption and, ultimately, weight loss. Additionally, semaglutide can slow down the emptying of the stomach, making individuals feel full for longer periods.

The drug also plays a role in improving insulin sensitivity and blood sugar control, which can be beneficial for individuals with insulin resistance or prediabetes. By addressing these underlying metabolic issues, semaglutide may contribute to overall weight loss and health improvements.

Potential Side Effects of Semaglutide

While semaglutide shows promise as a weight loss treatment, it is essential to be aware of the potential side effects associated with the drug. Common side effects may include nausea, vomiting, diarrhea, and constipation, which are often transient and improve over time as the body adjusts to the medication.

More serious side effects, although rare, can include pancreatitis, gallbladder problems, and kidney issues. It is essential to monitor for any unusual symptoms and seek medical attention if any concerning signs or symptoms arise while taking semaglutide.

Long-Term Effects and Safety Considerations

As semaglutide is a relatively new drug for weight loss, long-term effects are still being studied. While short-term trials have shown significant weight loss benefits, it is crucial to consider the potential impact of prolonged use of the medication on overall health and well-being. Close monitoring and regular follow-ups with a healthcare provider are essential for assessing the long-term safety of semaglutide.

Individuals considering semaglutide for weight loss should discuss their medical history, current medications, and any underlying health conditions with their healthcare provider before starting treatment. This will help ensure that semaglutide is a safe and appropriate option for their weight loss goals.





Conclusion

In conclusion, semaglutide presents a promising option for weight loss in non-diabetic individuals. By understanding how the drug works, being aware of potential side effects, and considering long-term safety implications, individuals can make informed decisions about incorporating semaglutide into their weight loss journey. As with any medication, it is essential to consult with a healthcare provider to determine the best course of action for achieving sustainable and healthy weight loss goals.

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