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Obesity, a driver of inflammation, is prevalent in patients with HFpEF. Ileana Pina asks Ambarish Pandey about GLP-1 inhibitors and SGLT2 inhibitors in HFpEF. Are these drugs anti-inflammatory? https://www.medscape.com/viewarticle/993980?src=soc_yt -TRANSCRIPT- Ileana L. Piña, MD, MPH: Hello, everyone. I'm Ileana Piña, professor of medicine at Jefferson University Hospital in Philadelphia. I'm the chief of quality. This is my blog. We have been hearing a lot of conversation about obesity. It's coming out of our endocrine division and our weight management division. And the patients are asking for things like bariatric surgery and maybe a holistic program of weight loss. A lot of the primary care doctors are starting to recommend glucagon-like peptide-1 (GLP-1) receptor agonists for those patients. But we deal with patients with heart failure with preserved ejection fraction (HFpEF), and a lot of our phenotypes are patients with obesity who happen to have hypertension and/or diabetes, and they are difficult to manage. Inflammation, Obesity, and HFpEF Piña: For today's conversation, there is nobody better than Dr Ambarish Pandey, who has a HFpEF program at the University of Texas Southwestern. Ambarish, welcome. Give me your thoughts overall about the link between obesity, inflammation, and HFpEF. Ambarish Pandey, MD: Thank you, Dr Piña. I'm excited to be on your blog and I'm glad that we are discussing such an important topic. The burden of heart failure, particularly HFpEF, has been increasing and is not just affecting older individuals. We see more younger folks with obesity in our HFpEF clinic coming in with symptoms of shortness of breath and fluid buildup. Our understanding of HFpEF has evolved quite a bit over the past two or three decades. Initially, it was thought to be a disease of largely impaired myocardial relaxation. And then Walter Paulus was one of the pioneers who proposed the concept of inflammation leading to HFpEF, and obesity being one of the important drivers of the inflammation that leads to the development of HFpEF. Now our understanding of HFpEF has evolved to it being a multisystem disorder that leads to dysfunction in different organ systems. One of the cardinal features that drives this dysfunction is upregulation of inflammatory pathways, increased inflammatory burden — and a lot of that is driven by obesity. Obesity is one of the most important modifiable risk factors for HFpEF. Piña: It is so common. In my clinic the other day, probably 3 out of 4 patients were obese. Pandey: Up to 75% of patients that we see in our program are over the 30 BMI cut-off, and a lot of the literature that has come from US HFpEF cohorts shows a very high average BMI in these patients. Piña: When we talk about inflammation, what are the chemical pathways of inflammation? For example, a long time ago, we tried to block TNF-alpha and it didn't quite work out. So, what pathways are we talking about? Pandey: I think a lot more work needs to be done to really understand the key drivers of inflammation and what pathways are being upregulated. As we know, inflammation is most commonly identified by elevation in levels of C-reactive protein (CRP), which serves as a marker of increased inflammation, but the upstream upregulation in IL-1– and IL-6–mediated pathways has been implicated in inflammation that drives development of diseases like HFpEF. There is an ongoing trial of ziltivekimab, which is an IL-1 inhibitor in patients with HFpEF. That's the HERMES trial led by Paul Ridker, one of the pioneers of inflammatory therapies in heart disease. We are starting to understand more about the key molecular pathways that are driving it. And now we're starting to target them, with the hope that we can actually halt the progression of HFpEF and improve the symptom burden as well as the risk for adverse outcomes in these patients. Are GLP-1 Inhibitors Anti-inflammatory? Piña: Do you think that the GLP-1s, or even now the SGLT2 inhibitors, are anti-inflammatory since we really don't know all the pathways? Pandey: I do think that GLP-1s, by virtue of causing weight loss and reduction in visceral adiposity and the bad fat depots that exist in our body, have a significant anti-inflammatory effect. And if you look at the data from the STEP trials that were done, looking at weight loss effects of semaglutide, a commonly used GLP-1 inhibitor, there was a good 30%-40% reduction in CRP levels, and that suggests that there is a significant anti-inflammatory effect. Now, whether it's a direct effect on anti-inflammatory pathways or is related to weight loss is a matter of debate. Piña: Are you using GLP-1 inhibitors in your HFpEF clinic? And what trials can we look forward to seeing concerning the use of these agents? https://www.medscape.com/viewarticle/993980?src=soc_yt
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Explore the promising impact of GLP-1 medications on obesity and how they can transform healthcare by preventing weight-related health issues. Discover the potential benefits for individuals and the healthcare system in this insightful discussion. #ObesityFuture #GLP1 #WeightManagement #HealthCare #PreventativeHealth #ChronicDisease #WellnessJourney #RevolutionaryMedications #HealthcareInnovation #HealthyLiving
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Natalie sits down with esteemed bariatric surgeon Dr. Michael Snyder to explore the transformative world of weight loss medications. Dr. Snyder, with over two decades of experience and up to 500 bariatric surgeries each year, shares the latest advancements in GLP-1 agonist drugs, including Ozempic, Semaglutide, Wagovi, and Tirzepatide. These groundbreaking medications offer significant long-term weight loss and have changed the landscape of non-surgical obesity treatment. Key Points Discussed: - Long-Term Medication Use: - Navigating uncertainties around continuing medications like Ozempic. - The importance of understanding and respecting the obesity process. - Weight Issues Categories: - Distinguishing between genetic predispositions and lifestyle-driven weight problems. - Highlighting the necessity of professional intervention for effective management. - Genetics and Epigenetics: - The role of genetic and environmental factors in weight gain. - Avoiding self-blame by understanding complex triggers. - Exercise and Physical Activity: - Practical exercise guidelines and the benefits of incremental activity for health. - Encouraging realistic, personalized exercise goals. - Sustainable Habits and Motivation: - Strategies for creating enjoyable, sustainable habits. - Using rewards to reinforce positive behaviors. - Holistic Approach to Weight Loss: - Combining medication with diet, exercise, and medical supervision. - Addressing both physical and psychological aspects of weight loss. - Practical Advice on Medication Use: - Importance of medical supervision and proper certification for compounded drugs. - Comprehensive health support including nutritional and lifestyle guidance. - Psychological Impact and Self-Perception: - Discussing the effect of weight on self-worth and mental health. - Encouraging a compassionate and holistic approach to weight management. Dr. Snyder also shares his personal journey with high cholesterol and the importance of medication when lifestyle changes aren’t enough, paralleling weight loss struggles. The episode closes with both Natalie and Dr. Snyder emphasizing the revolutionary impact of new weight loss drugs and the necessity of living life without judgment but with proper medical guidance. Don't forget to subscribe to our podcast and leave a review! #WeightLoss #Bariatrics #Health #Fitness #GLP1Agonists #Ozempic #Semaglutide #Wagovi #Tirzepatide #Parenting #SelfCompassion #HolisticHealth #MedicalGuidance #SustainableHabits #WeightLoss #Bariatrics #Health #Fitness #GLP1Agonists #Ozempic #Semaglutide #Wagovi #Tirzepatide #Parenting #SelfCompassion #HolisticHealth #MedicalGuidance #SustainableHabits Seeking Health Vitamins and Supplements: https://crrnt.app/SEEK/NgmAZXqO Before you go on Camera: https://www.natalietysdal.com/mediatraining Podcast Launch Guide: https://www.natalietysdal.com/mediatrainin Connect with Natalie 👉 Connect with Natalie! Website: https://www.natalietysdal.com Email: [email protected] Instagram: https://www.instagram.com/ntysdal/ Facebook: https://www.facebook.com/NatalieTysdal/ TikTok: https://www.tiktok.com/@ntysdal Pinterest: https://www.pinterest.com/ntysdal/ https://www.youtube.com/c/ntysdal Looka logo maker: https://looka.partnerlinks.io/us80hqy8cs8o Sign Up for Natalie’s Newsletter: https://page.natalietysdal.com/newsletter Thank you for helping us grow! https://page.natalietysdal.com/products/thanks Dr. Snyder: https://www.denverbariatrics.com/ #WeightLoss #Bariatrics #Health #Fitness #GLP1Agonists #Ozempic #Semaglutide #Wagovi #Tirzepatide #Parenting #SelfCompassion #HolisticHealth #MedicalGuidance #SustainableHabits
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Beim Abnehmen spielen Kalorien eine entscheidende Rolle. Um Gewicht zu verlieren, muss man weniger Kalorien zu sich nehmen, als man verbraucht. Doch wie berechnet man eigentlich die Kalorien, die man zum Abnehmen benötigt? In diesem Leitfaden werden wir Ihnen einen präzisen Überblick darüber geben, wie Sie Ihre Kalorienzufuhr zum Abnehmen berechnen können.
Warum ist es wichtig, die Kalorienzufuhr zu berechnen?
Die Kalorienzufuhr ist entscheidend, wenn es um das Abnehmen geht. Wenn Sie mehr Kalorien zu sich nehmen, als Ihr Körper verbrennt, nehmen Sie zu. Wenn Sie weniger Kalorien zu sich nehmen, als Ihr Körper verbrennt, nehmen Sie ab. Indem Sie Ihre Kalorienzufuhr kontrollieren und an Ihre individuellen Bedürfnisse anpassen, können Sie effektiv Gewicht verlieren.
Der erste Schritt beim Abnehmen ist die Bestimmung Ihres täglichen Kalorienbedarfs. Dieser hängt von verschiedenen Faktoren ab, wie Ihrem Geschlecht, Alter, Gewicht, Größe und Ihrem Aktivitätsniveau. Indem Sie Ihren Kalorienbedarf kennen, können Sie Ihr Ernährungs- und Trainingsprogramm entsprechend anpassen, um Ihr Ziel zu erreichen.
Das Verstehen Ihrer Kalorienzufuhr ist auch wichtig, um sicherzustellen, dass Sie ausgewogen und gesund essen. Indem Sie Ihre Kalorienzufuhr im Auge behalten, können Sie sicherstellen, dass Sie die richtigen Nährstoffe zu sich nehmen und Ihrem Körper die Energie geben, die er benötigt, um optimal zu funktionieren.
Wie berechne ich meinen täglichen Kalorienbedarf?
Es gibt verschiedene Formeln und Rechner, die Ihnen helfen können, Ihren täglichen Kalorienbedarf zu berechnen. Eine der einfachsten Methoden ist die Harris-Benedict-Formel, die Ihren Grundumsatz und Ihren Gesamtenergieumsatz berücksichtigt. Indem Sie Ihren Grundumsatz (die Kalorien, die Ihr Körper benötigt, um in Ruhe zu funktionieren) mit Ihrem Aktivitätsniveau multiplizieren, erhalten Sie Ihren Gesamtenergieumsatz.
Eine weitere Methode ist die Mifflin-St Jeor-Formel, die ähnlich funktioniert wie die Harris-Benedict-Formel, aber etwas genauer sein kann. Es gibt auch Online-Rechner, die Ihnen basierend auf Ihren persönlichen Daten und Zielen Ihren täglichen Kalorienbedarf berechnen können.
Es ist wichtig zu beachten, dass die berechneten Werte nur Schätzungen sind und je nach individuellen Faktoren variieren können. Es ist ratsam, Ihren Fortschritt zu überwachen und gegebenenfalls Ihre Kalorienzufuhr anzupassen, um sicherzustellen, dass Sie Ihre Ziele erreichen.
Wie kann ich meine Kalorienzufuhr kontrollieren?
Um Ihre Kalorienzufuhr zu kontrollieren, ist es hilfreich, eine Ernährungstagebuch zu führen, in dem Sie genau protokollieren, was Sie essen und trinken. Dadurch können Sie den Überblick behalten und feststellen, ob Sie Ihre Kalorienziele erreichen.
Es kann auch hilfreich sein, die Kalorien von Lebensmitteln und Getränken zu kennen, die Sie regelmäßig konsumieren. Auf diese Weise können Sie bewusstere Entscheidungen treffen und gegebenenfalls Alternativen wählen, die weniger Kalorien enthalten.
Weitere Möglichkeiten, Ihre Kalorienzufuhr zu kontrollieren, sind Portionen zu kontrollieren, auf Lebensmitteletiketten zu achten und Mahlzeiten im Voraus zu planen. Indem Sie sich bewusst sind, was und wie viel Sie zu sich nehmen, können Sie effektiv Ihre Kalorienzufuhr kontrollieren und Ihr Ziel erreichen.
Tipps und Tricks für eine erfolgreiche Gewichtsabnahme
Um erfolgreich Gewicht zu verlieren, ist es wichtig, nicht nur Ihre Kalorienzufuhr zu kontrollieren, sondern auch auf eine ausgewogene Ernährung zu achten. Stellen Sie sicher, dass Sie ausreichend Protein, gesunde Fette, Kohlenhydrate, Vitamine und Mineralstoffe zu sich nehmen.
Es ist auch wichtig, regelmäßig Sport zu treiben, um Ihren Stoffwechsel anzukurbeln und Kalorien zu verbrennen. Kombinieren Sie Cardio- und Krafttraining für optimale Ergebnisse und achten Sie darauf, sich ausreichend zu erholen, um Übertraining zu vermeiden.
Weitere Tipps sind, ausreichend Wasser zu trinken, ausreichend Schlaf zu bekommen, Stress zu reduzieren und sich selbst realistische Ziele zu setzen. Durch eine Kombination aus gesunder Ernährung, regelmäßiger Bewegung und einem gesunden Lebensstil können Sie erfolgreich Gewicht verlieren und Ihre Ziele erreichen.
Abschließend ist es wichtig zu betonen, dass jeder Mensch unterschiedlich ist und dass es keine Einheitslösung für alle gibt. Wenn Sie Schwierigkeiten haben, Ihre Kalorienzufuhr zu kontrollieren oder Gewicht zu verlieren, ist es ratsam, professionelle Hilfe in Anspruch zu nehmen. Ein Ernährungsberater oder Trainer kann Ihnen dabei helfen, einen auf Sie zugeschnittenen Plan zu erstellen und Sie auf Ihrem Weg zur Gewichtsabnahme unterstützen.
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The Sarah Keto Diet Pills have gained immense popularity following their appearance on the hit TV show Shark Tank. With many people curious about this product and its effectiveness, it’s important to delve into what makes these pills stand out in the crowded weight loss market. In this article, we will uncover the details behind Sarah Keto Diet Pills, examine their rise to fame post-Shark Tank, and explore the reasons for their growing popularity among consumers.
Breaking Down the Ingredients
One of the key factors contributing to the success of Sarah Keto Diet Pills is the carefully selected blend of ingredients. These pills contain a mix of natural components that work together to promote weight loss and improve overall health. Ingredients such as BHB (Beta-Hydroxybutyrate) help the body enter a state of ketosis, where it burns fat for fuel instead of carbohydrates. This process can lead to rapid weight loss and increased energy levels, making the pills a popular choice for those looking to shed excess pounds.
Additionally, Sarah Keto Diet Pills are packed with antioxidants and other beneficial compounds that support overall wellness. By incorporating ingredients that boost metabolism and suppress appetite, these pills provide a comprehensive approach to weight management. With a focus on natural and safe ingredients, users can enjoy the benefits of the pills without worrying about harmful side effects.
The Science Behind the Product
Another reason for the growing popularity of Sarah Keto Diet Pills is the scientific evidence backing their effectiveness. Studies have shown that the ketogenic diet, which the pills are designed to complement, can lead to significant weight loss and improved health outcomes. By mimicking the effects of a keto diet, these pills offer a convenient and accessible way for individuals to reap the benefits of ketosis without strict dietary restrictions.
Moreover, the makers of Sarah Keto Diet Pills have conducted extensive research to ensure that their product delivers on its promises. With a focus on quality and efficacy, these pills undergo rigorous testing to guarantee their safety and effectiveness. By combining scientific principles with natural ingredients, the pills offer a winning formula for achieving weight loss and wellness goals.
User Testimonials and Success Stories
In addition to the scientific evidence supporting Sarah Keto Diet Pills, user testimonials and success stories have played a significant role in their popularity. Many individuals who have tried the pills report noticeable results in terms of weight loss, increased energy, and improved overall health. These real-life accounts serve as powerful testimonials to the efficacy of the product and have contributed to its positive reputation among consumers.
By sharing their experiences with Sarah Keto Diet Pills, users have helped to spread the word about the product and its benefits. Whether through social media, word of mouth, or online reviews, these testimonials have created a buzz around the pills and fueled their rising popularity. As more people hear about the positive outcomes achieved with the product, interest in Sarah Keto Diet Pills continues to grow.
Availability and Pricing
For those interested in trying Sarah Keto Diet Pills for themselves, the product is readily available for purchase online. Many retailers stock the pills, making it easy for customers to access them and start their weight loss journey. Pricing for the product varies depending on the supplier and any ongoing promotions, but in general, Sarah Keto Diet Pills are considered affordable and cost-effective compared to other weight loss supplements on the market.
With a simple ordering process and convenient delivery options, customers can quickly get their hands on Sarah Keto Diet Pills and begin reaping the benefits. Whether seeking to kickstart weight loss, boost energy levels, or improve overall wellness, these pills offer a practical and sustainable solution for achieving health and fitness goals. As more people discover the effectiveness of Sarah Keto Diet Pills, their popularity is expected to continue rising in the coming years.
FAQ
Q: Are there any side effects associated with Sarah Keto Diet Pills?
A: While Sarah Keto Diet Pills are made from natural ingredients and are generally well-tolerated, some individuals may experience mild side effects such as digestive issues or headaches. It is recommended to consult with a healthcare provider before starting any new supplement regimen.
Q: How long does it take to see results with Sarah Keto Diet Pills?
A: The timeline for seeing results with Sarah Keto Diet Pills can vary depending on the individual’s body composition, metabolism, and lifestyle factors. Some users may experience weight loss and increased energy within a few weeks of starting the pills, while others may take longer to notice significant changes.
Q: Can Sarah Keto Diet Pills be used as a standalone weight loss solution?
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