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Drs Piña and Kosiborod discuss semaglutide in obesity-related HF with and without diabetes. Both STEP HFpEF trials show similar HF benefits despite less weight loss in patients with diabetes. https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_yt -- TRANSCRIPT -- Ileana L. Piña, MD, MPH: Hello, and welcome to my blog. Today, I'm at the American College of Cardiology in Atlanta. I want to introduce and welcome Dr Kosiborod: from the Mid America Heart Institute, who has presented a very impactful paper, STEP HFpEF DM, that is in The New England Journal of Medicine right now. This is about semaglutide. A lot of patients ask me to give them that pill that makes them lose weight. I see primarily patients with heart failure (HF). So, Mikhail, congratulations on your presentation. Give us a little synopsis of what the trial is about. The STEP HFpEF Program Mikhail N. Kosiborod, MD: First of all, it is always a pleasure to be with you. Maybe a quick word about the STEP HFpEF program that included two trials: The first is STEP HFpEF, which was a trial of patients with obesity-related HF with preserved ejection fraction (HFpEF) who did not have diabetes, which we presented and published at European Society of Cardiology in August last year. The second installment of the program is the STEP HFpEF diabetes trial, which is essentially the same population of patients except they also have type 2 diabetes. I guess your question would be why we did two trials instead of just doing one trial that included patients, both with and without diabetes. I'll come back to that shortly. The crux of the hypothesis behind the program is that we all know the prevalence of HFpEF has increased dramatically in the past couple of decades. When I was a fellow in training, it was rare for me to see a patient with HF who had preserved EF. A majority of patients had HF with reduced EF. Now, the majority of people we see have HFpEF: Why did that happen? There are a lot of different reasons for the dramatic change in epidemiology. But certainly, one of them, at least in our opinion, is that the obesity epidemic has a lot to do with it. In fact, if you look at the population of patients with HFpEF in the United States, 80% of them are living with overweight or obesity. The hypothesis behind the program was that obesity is not just a comorbidity. It doesn't just happen to coexist by accident in this patient population, it may in fact be causing their HF. It may be a critical factor in the development and progression of HFpEF. In order to test our hypotheses, patients were randomly assigned to semaglutide, with the target dose of 2.4 mg once a week or matching placebo and treated for 52 weeks, or 1 year. The reason we did two separate trials is because part of that hypothesis was that if obesity is in fact the cause of HF, then certainly, weight loss would be probably not the only factor but "an important factor in the potential benefits of semaglutide in this patient population, provided that semaglutide is beneficial which of course we ultimately demonstrated. But what we knew from weight-loss trials — not HF trials but weight-loss trials of medications like semaglutide and also other anti-obesity medications like tirzepatide and others — is that people with diabetes tend to lose a lot less weight. With these medications, there's about a 40% less weight loss in people with type 2 diabetes. Lots of theoretical reasons why that could be the case. Nobody really knows for sure. We knew from the beginning that the weight loss likely was going to be different. Then, of course, there are other things that happen in people with diabetes: They have more severe HFpEF phenotype, and people with more severe disease sometimes don't respond to treatment the same way as those with less severe disease. Finally, we knew when we started the trial, which was back around 2019, 2020, that people with diabetes would be more likely to be treated with sodium-glucose cotransporter 2 (SGLT2) inhibitors. At the time, we didn't have the data for SLT2 inhibitors in HFpEF, but we knew that were going to be tested. There was, of course, an expectation that they may well be beneficial. For all of these reasons, we said, "You know what, the treatment effects may well be different between the patient population, but let's study them separately." Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_yt
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Exploring the Benefits of Lemon Balm for Weight Management
Lemon balm, scientifically known as Melissa officinalis, is a perennial herb in the mint family, celebrated for its fresh, lemony fragrance and soothing properties. Traditionally used in herbal teas and remedies, lemon balm has recently gained popularity as a supporting ingredient in weight loss recipes. Its myriad of benefits extends beyond its delightful aroma and flavor; it is believed to aid digestion, mitigate stress, and promote overall wellness, making it a fantastic companion on the journey toward healthier living. As many individuals pursue their weight loss goals, the incorporation of lemon balm can potentially enhance their efforts by promoting a more balanced lifestyle.
This herb is revered not just for its taste and scent, but also for its potential role in weight management. The remarkable herbal properties of lemon balm assist in calming the mind, which can deter emotional eating—a common hurdle in weight loss journeys. Stress is often a hidden factor that sabotages diet efforts, leading to cravings and poor food choices. By using lemon balm regularly, individuals can support their mental health and create an environment conducive to healthy eating.
Furthermore, lemon balm is rich in antioxidants, which are vital in combating oxidative stress and inflammation within the body. Effective antioxidant levels help maintain metabolic health, which is essential for anyone hoping to shed extra pounds. The herb’s potential ability to improve digestion through its gastroprotective qualities also means better nutrient absorption and a more efficient metabolism—two critical components for weight management. In this article, we’ll delve deeper into various recipes and methods of incorporating lemon balm into your daily routine, showcasing its potential to help you achieve your health goals while enjoying tantalizing flavors.
Delicious Lemon Balm Infused Water
One of the simplest and most refreshing ways to introduce lemon balm into your daily routine is by making lemon balm infused water. This vibrant drink not only hydrates but also infuses your water with the calming essence of lemon balm. To prepare, gather a handful of fresh lemon balm leaves, rise them thoroughly, and place them in a pitcher filled with distilled water. For an extra flavor kick, squeeze in the juice of one fresh lemon and add slices of cucumber or strawberries for a delightful twist.
After combining these ingredients, let the pitcher sit in the refrigerator for at least four hours or overnight. This allows the ingredients to mingle, resulting in a refreshing drink that is both delicious and beneficial. Drinking lemon balm infused water can provide hydration, curb cravings, and promote relaxation, making it a perfect beverage for those on a weight loss plan. It’s a flavorful alternative to sugary drinks and can be enjoyed at any time of the day, whether as a morning refresher or a soothing evening beverage.
In addition to weight loss benefits, lemon balm infused water can offer other health advantages. The hydration from the water, combined with lemon balm’s calming properties, can help reduce stress. Staying hydrated is crucial during weight loss, as often, thirst can be mistaken for hunger, leading to unnecessary snacking. Combining the refreshing flavors of lemon, cucumber, or strawberry with lemon balm ensures you have a drink that feels indulgent without the added calories—an ideal solution for managing cravings while keeping your body well-hydrated.
Lemon Balm Herbal Tea for Calming Moments
Lemon balm herbal tea is another delightful way to harness the benefits of this herb while also indulging the senses. Preparing lemon balm tea is straightforward, requiring only a few fresh or dried leaves steeped in hot water. For added flavor, consider mixing lemon balm with other herbs, such as chamomile or peppermint, to create a soothing blend. Enjoying a cup of lemon balm tea can be an excellent ritual, especially during stressful moments that could lead to emotional eating.
Research suggests that lemon balm possesses anxiolytic properties, which aid in reducing anxiety and promoting a calm mind. By incorporating this herbal tea into your routine, especially during times of heightened stress, you can train your body to respond more favorably to emotional triggers that often lead to overeating. Furthermore, sipping on warm herbal tea can produce a sense of fullness, which may help reduce overall caloric intake throughout the day.
Active weight loss comes not only from dietary changes but also from addressing the mental and emotional aspects of eating. Regularly consuming lemon balm tea can reinforce the body’s natural response to stress, encouraging healthier eating patterns. Whether you choose to enjoy it in the morning, midday, or as an evening ritual, lemon balm tea offers a comforting way to prioritize your health goals while also enjoying the soothing properties of this fantastic herb.
Lemon Balm Smoothie for Nutrient Boost
Crafting a lemon balm smoothie can serve as a nutrient-dense meal or snack while allowing you to enjoy the flavorful benefits of this herb. A smoothie featuring lemon balm is not only delicious but can also be a powerful ally in your weight loss goals. Start by combining a handful of fresh lemon balm leaves with your preferred fruits, such as bananas, berries, or mangoes, in a blender. Adding spinach or kale can further enhance the nutritional value while keeping the flavor bright and fresh.
Incorporating a protein source, such as Greek yogurt or plant-based protein powder, will help create a well-rounded smoothie that keeps you full and satisfied. To boost hydration, add coconut water or almond milk. The refreshing taste of lemon balm enhances the overall flavor profile, making your smoothie a delightful treat. This approach can be a dynamic way to start the day or a quick option for lunch or snack breaks.
The key advantage of using lemon balm in a smoothie is the combination of nutrients from fruits and vegetables with the calming effects of the herb. Balanced blood sugar levels prevent sudden energy drops, which can lead to cravings for unhealthy snacks. Moreover, the addition of healthy fats, such as avocado or nut butter, can further promote satiety and enhance the overall creaminess of your smoothie. With lemon balm as a star ingredient, you create a deliciously satisfying drink that nourishes the body and mind alike.
Incorporating Lemon Balm into Daily Meals
Lemon balm can be added creatively to various dishes beyond drinks. Its bright, citrusy flavor lends itself well to salads, dressings, and even main dishes. When preparing a fresh salad, consider tossing in finely chopped lemon balm leaves along with your favorite vegetables and a light vinaigrette. The herb adds a refreshing twist, elevating the salad without the need for excessive dressings or caloric toppings.
For a standout meal, try marinating grilled chicken or fish with a mixture of lemon balm, olive oil, and lemon juice. This combination not only infuses the dish with flavor but also creates a healthier cooking option. The antioxidants in lemon balm may contribute to reduced inflammation, further supporting your health efforts on your weight loss journey. Incorporating herbs like lemon balm into seasoned proteins encourages more wholesome meals without sacrificing taste.
Moreover, adding lemon balm to your meals can serve as a step towards mindful eating. Engaging with your food, appreciating flavors, and building balanced meals makes the experience of eating more enjoyable and fulfilling. Incorporating lemon balm into your diet may provide a small yet impactful change that helps you align your culinary choices with your health goals.
Answering Your Questions About Lemon Balm for Weight Loss
Many people have questions about how lemon balm can fit into their weight loss strategy. One frequent inquiry revolves around how effective lemon balm can be when integrated into a weight loss plan. While lemon balm is not a miracle solution for weight loss, its calming properties and ability to reduce stress, coupled with its flavor enhancement, certainly make it a beneficial addition. When combined with a balanced diet and regular exercise, it supports overall health goals.
Another common question concerns the best ways to use lemon balm. The versatility of this herb is one of its most appealing features. You can enjoy it as an infused water, a refreshing tea, or incorporated into smoothies and dishes. Experimenting with fresh leaves in salads or dressings adds an exciting layer of flavor to meals. Ultimately, the best method is the one that fits seamlessly into your lifestyle, ensuring that you can maintain your health goals comfortably.
Lastly, many wonder if there are any side effects associated with lemon balm. Generally, lemon balm is safe when consumed in typical food amounts. However, if you’re pregnant, nursing, or taking medications, particularly for thyroid disorders, it’s wise to consult a healthcare professional before incorporating it into your regimen. By being informed and mindful in your approach, you can create a personalized experience that enhances your weight loss journey through the delightful incorporation of lemon balm.
New Weight Loss Drug In Development
An effective fat loss diet is not something that you gather by reading everyday diet tips. Specially when you are thinking of losing weight fast you must have a proper plan and you must know that its a combination of things and not just an effective fat loss diet itself.
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Wegovy (aka semaglutide) and Zepbound (aka tirzepatide) are two effective weight loss drugs, which have taken the market by storm. But which is more effective? A brand new, authoritative clinical trial pitched the two drugs against each other to find out.
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GeminiKeto is a trending diet plan that has gained popularity in recent years for its promising results in achieving weight loss and improving overall health. This low-carb, high-fat diet focuses on putting the body into a state of ketosis, where it burns fat for fuel instead of carbohydrates. By following the principles of the GeminiKeto diet, individuals can experience increased energy levels, mental clarity, and weight loss without feeling deprived or hungry.
Understanding the GeminiKeto Diet
The GeminiKeto diet is derived from the traditional ketogenic diet, but with a slight variation that makes it more sustainable for long-term use. This diet emphasizes consuming healthy fats, moderate protein, and very minimal carbohydrates to switch the body’s energy source from glucose to ketones. By following this approach, individuals can achieve a metabolic state called ketosis, where the body burns stored fat for fuel instead of relying on carbohydrates.
One of the key principles of the GeminiKeto diet is to restrict carbohydrate intake to around 20-50 grams per day, depending on individual needs. This low-carb approach forces the body to produce ketones from fat stores, which can help with weight loss and improving overall health. Additionally, by consuming healthy fats such as avocados, nuts, and olive oil, individuals can stay satiated and avoid cravings for sugary or processed foods.
Another important aspect of the GeminiKeto diet is to focus on high-quality, nutrient-dense foods that provide essential vitamins and minerals. By incorporating plenty of leafy greens, vegetables, and lean proteins into their meals, individuals can ensure they are getting all the necessary nutrients while still following a low-carb, high-fat diet. This balanced approach can enhance overall health and support weight loss goals.
The Benefits of GeminiKeto
One of the main benefits of the GeminiKeto diet is its ability to promote weight loss in a sustainable and effective way. By reducing carbohydrate intake and increasing healthy fats, individuals can experience a reduction in body fat, improved metabolism, and increased energy levels. This can lead to a healthier body composition and a lower risk of chronic diseases associated with obesity.
Another advantage of the GeminiKeto diet is its potential to improve cognitive function and mental clarity. By utilizing ketones as the primary energy source, the brain can function more efficiently, leading to enhanced focus, memory, and overall cognitive performance. This can be particularly beneficial for individuals looking to improve their mental sharpness and productivity.
Additionally, the GeminiKeto diet has been shown to have positive effects on various health markers, such as blood sugar levels, cholesterol levels, and blood pressure. By following a low-carb, high-fat diet, individuals can improve insulin sensitivity, reduce inflammation, and lower their risk of developing chronic diseases such as type 2 diabetes and heart disease. This can lead to a longer, healthier life with reduced risk of age-related illnesses.
Tips for Success on GeminiKeto
One of the keys to success on the GeminiKeto diet is meal planning and preparation. By taking the time to plan out your meals and snacks ahead of time, you can ensure you have healthy options available when hunger strikes. This can help you avoid reaching for convenient but unhealthy choices that may derail your progress on the diet.
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It’s also important to stay hydrated while following the GeminiKeto diet, as dehydration can lead to fatigue, headaches, and other negative side effects. Drinking plenty of water throughout the day can help flush out toxins, support digestion, and maintain electrolyte balance, especially as your body adjusts to burning fat for fuel instead of carbohydrates.
Furthermore, incorporating regular exercise into your routine can enhance the benefits of the GeminiKeto diet by promoting fat burning, maintaining muscle mass, and improving overall fitness levels. Whether you enjoy cardio, strength training, yoga, or other forms of physical activity, finding activities that you enjoy can help you stay motivated and engaged in your health journey.
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