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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)
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Bringing It All Together: The Comprehensive Benefits of Keto ACV Pills
The combination of the ketogenic diet and the benefits of apple cider vinegar encapsulated in pill form offers a host of metabolic advantages that can streamline weight loss efforts. By enhancing fat oxidation, regulating blood sugar levels, boosting metabolic rate through thermogenesis, and supporting digestive health, Keto ACV pills position themselves as an effective tool for users who wish to elevate their metabolic performance.
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However, as with any supplement, it is essential to consult healthcare professionals before adding Keto ACV pills to your regimen. Personal health factors and goals, including existing medical conditions and dietary preferences, can influence the effectiveness and safety of using such supplements. Individuals interested in maximizing their metabolism should approach any supplementation thoughtfully and holistically.
Summary and Frequently Asked Questions
In summary, Keto ACV pills emerge as a compelling option for those aiming to boost their metabolism and manage their weight effectively. With scientifically substantiated benefits, they harness the combined powers of a ketogenic approach and apple cider vinegar to enhance metabolic health. Understanding the different mechanisms through which these pills operate empowers users to incorporate them into their wellness journeys confidently.
A frequent question surrounds the efficacy of Keto ACV pills compared to traditional apple cider vinegar consumption. While both share similar properties, pills offer a convenient way to achieve the desired acetic acid intake without the strong taste or acidity of liquid vinegar. Additionally, the concentration in pill form ensures that users receive a consistent dose, optimizing their results.
Another concern may involve dosage and safety. Generally, a recommended dose of Keto ACV pills is provided by manufacturers, and it is crucial for users to adhere to getting the best outcomes without overconsumption. It is also advisable to pair any supplement regimen with a balanced diet and regular physical activity for maximum effectiveness.
Potential users may also inquire about any side effects associated with these pills. While most individuals tolerate Keto ACV pills well, some may experience mild gastrointestinal discomfort. If symptoms persist, it is prudent to consult a healthcare provider. In conclusion, Keto ACV pills appear to unlock a myriad of metabolic benefits, placing them among practical aids for those on a quest for improved health and weight management.
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