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Semaglutide, a medication once used to treat type 2 diabetes, has recently gained popularity for its off-label use as a weight-loss drug. The drug, marketed under the brand name Wegovy, has shown significant results in clinical trials, with participants experiencing dramatic weight loss compared to those who took a placebo. This has led many people struggling with obesity to turn to Semaglutide as a potential solution for their weight loss goals.

Semaglutide Mechanism of Action

Semaglutide works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) that is naturally produced in the body. GLP-1 helps regulate blood sugar levels and appetite, making it an important factor in weight management. By activating GLP-1 receptors in the brain, Semaglutide can help reduce hunger and increase feelings of fullness, leading to decreased food intake and ultimately weight loss.

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Aside from its effects on appetite regulation, Semaglutide also slows down the emptying of the stomach, further contributing to feelings of fullness and reduced food intake. It also aids in the regulation of blood sugar levels, making it a beneficial treatment option for individuals with diabetes or prediabetes.





Additionally, Semaglutide has been shown to have a positive impact on body composition, reducing visceral fat (fat stored around organs) and improving metabolic markers such as cholesterol levels and blood pressure. This makes Semaglutide not only effective for weight loss but also for overall health improvement.

Semaglutide Dosage and Administration

When used for weight loss, Semaglutide is typically administered once weekly via subcutaneous injection. The starting dose is usually low to minimize potential side effects, with gradual dose escalation over several weeks to reach the maintenance dose. It is important to follow the prescribed dosing schedule and not exceed the recommended dose without consulting a healthcare provider.

Prior to starting Semaglutide treatment, individuals are advised to undergo a thorough medical evaluation to assess their suitability for the medication. This may include monitoring liver function, kidney function, and other metabolic parameters to ensure the safe and effective use of Semaglutide for weight loss.

Regular follow-up appointments with a healthcare provider are crucial while taking Semaglutide to monitor progress, adjust dosage if necessary, and address any concerns or side effects that may arise. It is essential to adhere to the recommended treatment plan and lifestyle modifications to maximize the benefits of Semaglutide for weight loss.

Semaglutide Cost and Insurance Coverage

One of the key considerations for individuals interested in using Semaglutide for weight loss is the cost of the medication. As an off-label use, Semaglutide may not be covered by insurance for weight loss purposes, resulting in out-of-pocket expenses for many individuals. The cost of Semaglutide can vary depending on the dosage strength, quantity of injections, and pharmacy dispensing the medication.

Some pharmaceutical companies may offer assistance programs or discounts to help offset the cost of Semaglutide for eligible patients. It is recommended to inquire with the prescribing healthcare provider or pharmacist about potential cost-saving options and explore alternative medications or weight loss strategies if affordability is a concern.

Despite the potential cost implications, many individuals find the benefits of Semaglutide for weight loss to outweigh the financial investment, especially when considering the long-term health improvements and quality of life enhancements that can result from successful weight management.

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Why These Drugs Aren’t Magic Bullets—And How to Maximise Their Clinical Impact The sharp rise in GLP-1 agonist prescriptions – up over 42% in Australia since 2019 – is reshaping how we approach weight loss and metabolic health. But are we ready to support patients beyond the script? In this evidence-informed episode, dietitian and exercise scientist Robbie Clark joins us to unpack the clinical realities of GLP-1 medications like Ozempic® and Wegovy®. Far from being quick fixes, these medications work best when combined with targeted nutrition, resistance training, and gut support. Robbie explores how GLP-1 agonists enhance insulin secretion, suppress appetite, and deliver cardiovascular benefits, while sharing practical strategies to enhance patient outcomes and minimise side effects. From optimising protein intake (1.2–1.6 g/kg) to prevent muscle loss, to managing nausea and reflux, you’ll gain the tools to confidently guide your patients through every stage of their GLP-1 journey. We also dive into the surprising science of bitter foods – like dandelion, grapefruit, and dark chocolate – that naturally stimulate GLP-1 receptors, offering a food-first support strategy that complements medication. Perhaps most crucial is the discussion on weight regain post-discontinuation, with studies showing 60–100% of lost weight can return within a year without lifestyle foundations. Robbie provides realistic, sustainable strategies to help patients move from medication reliance to long-term metabolic resilience. Whether you’re currently supporting patients on GLP-1 medications or preparing for their growing use in practice, this episode delivers the clinical insights you need to turn short-term interventions into lasting lifestyle change Connect with Robbie: healthbank.io Shownotes and references are available on the Designs for Health website Register as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.au Follow us on Socials Instagram: Designsforhealthaus Facebook: Designsforhealthaus DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health.

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In this episode of the Transformation Weight Control Podcast, Alex and Rich, along with TWC participant and guest Marc G, discuss the complexities of weight loss, the role of medication, and the importance of lifestyle changes. Marc shares his personal journey of struggling with obesity, the impact of food noise, and how medication has transformed his relationship with food. The conversation emphasizes the significance of exercise, the challenges of societal biases regarding weight, and the importance of community support in achieving lasting change. Marc participates in the TWC Weight Loss Medication Support Group, the only one in the country, which meets once a week for 75 minutes led by health-care professionals including a registered dietitian. For more information you can click here: https://transformationweightcontrol.com/12-week-weight-loss-medication-support-group/ or email Rich Weil, TWC Director, at [email protected] CHAPTERS: 00:00 Introduction to Transformation Weight Control Podcast 02:35 Marc's Weight Loss Journey: Struggles and Triumphs 11:38 The Role of Medication in Weight Management 18:17 Understanding Food Addiction and Mental Noise 24:31 Normalizing Appetite Regulation and Portion Control 42:24 Transformative Experiences with Weight Loss Medications 44:48 Mindfulness and Nutrition Tracking 47:39 Adapting Diet for Health and Energy 50:27 Incorporating Exercise into Daily Life 52:37 Addressing Medication Bias and Chronic Disease 59:37 The Role of Community Support in Weight Loss 01:05:48 Final Thoughts on Weight Loss Journey and Medications

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Robert A. Gabbay, MD, PhD, discusses the use of basal insulin in combination with a glucagon-like peptide-1 receptor agonist for the treatment of patients with diabetes.

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The ketogenic diet has gained massive popularity in recent years for its ability to help people lose weight and improve their overall health. One of the key components of the keto diet is ketosis, a metabolic state where the body burns fat for fuel instead of carbohydrates. However, achieving and maintaining ketosis can be challenging, especially for beginners. That’s where K1 Keto Gummies come in. These gummies are specially formulated to accelerate the process of ketosis, making it easier for you to reach your weight loss goals.

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