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🎤 In Episode 10: Dr. Iain Campbell, Matt Baszucki & Oliver Seligman discuss the ketogenic diet, ketogenic research, and other metabolic strategies that can support people with bipolar disorder. They unpick the benefits, challenges, and future of ketogenic therapy & other metabolic strategies. This video is from an episode of Dr. Iain Campbell and Matt Baszucki's fascinating podcast channel, Keto Bipolar (see link below). Matt, diagnosed with bipolar type one in his teens, is one of the most well know proponents of metabolic and ketogenic treatments for bipolar disorder. He spends much of his time raising awareness and sharing his story of how he came back from the brink of death to living a great life alongside bipolar disorder. Iain, a well respected Academic Fellow at Edinburgh University, and pioneering Bipolar-Metabolic researcher has bipolar type two. Finding much relief from his symptoms through keto and metabolic strategies, he headed up the first bipolar-ketogenic therapy research study ever published. By a twist of fate, Oliver Seligman, author of Befriending Bipolar, was a participant on Dr. Campbell's Bipolar-Ketogenic Pilot study. After benefiting greatly from a ketogenic diet, he is now an advocate for metabolic therapies. ------------------------------------------------------------ 🔗 Useful Links: - Check out the Pilot study: https://pubmed.ncbi.nlm.nih.gov/37814952/ - Hear Dr. Campbell talk about the results: https://www.youtube.com/watch?v=v3zEbwfbVP0&t=1s - For more info on ketogenic diet and mental health check out: www.metabolicmind.org Follow Matt & Iain on X here: @baszuckimatt @iaincampbellphd Follow Matt & Iain's Youtube channels here: @ketobipolar: https://www.youtube.com/@ketobipolar @mattbaszucki: https://www.youtube.com/@mattbaszucki ------------------------------------------------------------ 🌐 Oliver Seligman's website (where you can sign up for my monthly newsletter): www.oliverseligman.com ☕ If you would like to support Oliver's channel you can buy me a coffee on: https://buymeacoffee.com/oliverseligman All support is greatly appreciated 🙏 If you are interested in reading My book Befriending Bipolar: a patient's perspective: 📚 You can purchase Befriending Bipolar on Amazon (US) at: https://amzn.to/3FXTP7A 👨 If you would like to work with me as a coach, please contact me through Instagram: https://www.instagram.com/oliver.seligman/ ------------------------------------------------------------ Please note that the content provided in this podcast (and video) is for informational and lived experience storytelling purposes only. While the podcast aims to foster understanding and empathy through real-life stories, this platform does not offer medical advice, diagnosis, or treatment. The experiences and opinions expressed by the hosts and our guests are their own. We strongly encourage listeners to seek professional medical advice for any mental health concerns. This podcast is not a substitute for professional care by a doctor or other qualified healthcare professionals. Always consult your healthcare provider for any questions you may have regarding a medical condition, and never disregard professional medical advice or delay in seeking it because of something you have heard on this channel or podcast. ---------- Chapters 0:00 - 2:21 The Ketogenic-Bipolar Pilot Trial 2:22 - 6:08 The Benefits of A Keto Diet 6:09 - 7:40 Taking Keto For Granted 7:41 - 8:35 Keto Versus Carnivore 8:36 - 9:50 Coming Off Lithium 9:51 - 12:43 Back On Lithium 12:44 - 19:56 Psychiatrists, Psych Meds & A Revolution 19:57 - 24:28 Reduced Anxiety, Glutamate & Weight 24:29 - 27:40 Ketosis, Fat and A Revolution 27:41 - 31:23 GOP1's, Epilepsy, Healing Bipolar 31:24 - 37:03 Strategies: Exercise, Enjoyment, The Moment 37:04 - 39:35 Baszucki Award 39:26 - 44:00 Keto Helps 44:01 - 49:33 Meditation 49:34 - 52:40 Stay Realistic, Investigate Ketogenic Diet, Nutritionist, Doctor On Board ✋ Disclaimer: This Youtube channel's intention is to educate and foster a greater understanding of bipolar disorder through the lens of people who live with this mental illness. The experiences and opinions expressed by those who appear on this channel are their own. They do not offer medical advice, diagnosis, or prescribe the use of any technique as a form of treatment for physical, mental, or emotional problems. The videos on this channel are not a substitute for professional care by a doctor or other qualified healthcare professionals. Never disregard professional medical advice, or delay in seeking it, because of something you have heard on this channel. ✋ This video is not sponsored and has no affiliate links. #Bipolarjourney #MentalHealthJourney #Lithiumlife #LivingWithBipolar

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Embarking on a Journey of Health and Transformation

Garth Brooks, an iconic figure in the world of country music, has not only captivated audiences with his powerful voice and engaging performances but has also inspired many through his journey towards better health and well-being. Over the years, he has undergone significant changes, shedding pounds and embracing a healthier lifestyle that serves as a testament to perseverance and dedication. What prompted this transformation? For Brooks, it has always been about more than just aesthetics; it’s about feeling good, living healthy, and being there for his family and fans for years to come.

Throughout the 1990s and 2000s, Garth Brooks enjoyed immense success, with numerous hit songs, sold-out stadium tours, and a loyal fan base. However, with the pressures of fame, combined with an exhaustive schedule, maintaining a balanced lifestyle became increasingly challenging. As the years went by, Brooks found himself at a weight he was not comfortable with, impacting both his physical health and mental well-being. The turning point came when Brooks realized that to sustain his career and personal life, he needed to prioritize his health.

Today, Garth Brooks is not just a country music superstar; he is also an advocate for health and fitness, sharing his journey with fans and inspiring many to embark on their own paths to health. His weight loss journey continues to resonate with people from all walks of life, proving that with hard work, determination, and a focus on personal goals, transformation is possible. This article explores the details of Garth’s journey, the challenges he faced, and the lifestyle changes that have set him on a path to health and happiness. Through the various sections, we will delve deeper into his experiences, motivations, and the impact of his journey on his life and career.

The Realization: Acknowledging the Need for Change

Garth Brooks’ journey to weight loss began with a poignant realization that sparked a need for change. After years of living a fast-paced lifestyle filled with concerts, studio sessions, and promotional events, Brooks found himself at a crossroads. While his career was flourishing, personally, he felt a disconnect between his physical health and his life aspirations. This epiphany was the gradual culmination of numerous factors, including health scares and a desire to be present for his family. The stress of a demanding schedule often led to unhealthy eating habits, which ended up being a vicious cycle that contributed to weight gain.

Another critical moment of reflection came when Brooks faced the harsh reality of the toll that his fame had taken on his well-being. The pressures of maintaining an image as a country music star can be overwhelming, and Garth was no stranger to that burden. He understood that the key to longevity in his career was not just about hitting the high notes but also about ensuring that he had the physical stamina to keep performing at the level that fans expected. This prompted him to take a deep dive into his lifestyle choices, ultimately leading to the decision to embrace a healthier lifestyle.

In recognizing the need for change, Brooks set forth a clear intention: to take charge of his health. The initial steps included consulting nutritionists and fitness trainers, who could guide him in creating a manageable plan tailored to his individual needs. This structured approach allowed him to address his eating habits head-on while also introducing exercise into his daily routine. With every step he took, Brooks not only shed pounds but also regained the confidence he needed to reclaim his physical and mental health, enabling him to perform better and enjoy a more fulfilling life.

Creating a Sustainable Approach to Fitness

Once Garth Brooks recognized the importance of changing his lifestyle, he began to develop a sustainable approach to fitness and health. This transformative journey involved more than just a crash diet or short-term fitness routine; it was about creating lifelong habits that would promote well-being. Brooks understood that merely losing weight was not the ultimate goal; rather, he wanted to cultivate a holistic lifestyle that incorporated healthy eating, regular exercise, and mental wellness.

To achieve this, Garth Brooks focused on his dietary choices, opting for nutrient-dense foods that fueled his body and provided sustained energy. He replaced processed and high-calorie foods with wholesome alternatives, including fruits, vegetables, lean proteins, and whole grains. By diligently planning his meals and being mindful of portion sizes, Brooks was able to make significant strides towards his weight loss goals. His commitment to meal prepping and cooking at home allowed him to control what he consumed, a vital aspect of maintaining a healthy lifestyle.

In addition to dietary changes, Garth incorporated regular physical activity into his routine. Finding activities that he enjoyed made this process enjoyable rather than a chore. Whether it was hitting the gym, going for a run, or engaging in outdoor activities, Brooks discovered that maintaining an active lifestyle was both liberating and energizing. Over time, exercise became an integral part of his daily life, not just for burning calories but also for fostering a sense of accomplishment and improving his overall mental health.

Overcoming Challenges and Staying Motivated

Garth Brooks’ journey was not without its challenges. While he was dedicated to his health transformation, there were moments where maintaining his motivation became difficult. The glamorous lifestyle, filled with sumptuous meals during tours and social events, presented temptations that tested his resolve. Moreover, with a demanding career, it was easy to slip back into old habits, leading to weight fluctuations and self-doubt. Recognizing these potential pitfalls was crucial for Brooks in crafting a response to adversity.

To tackle these challenges, Brooks developed a strong support system that included his family, friends, and health professionals. He involved his loved ones in his transformation journey, seeking their encouragement and accountability. Sharing his goals with those close to him helped Brooks remain steadfast in his pursuit of health. Having a support network proved invaluable, particularly during tougher times when the temptation to revert to bad habits arose. It is well known that the presence of a community can aid in overcoming personal challenges.

Moreover, Brooks cultivated techniques for self-motivation and discipline. Setting realistic goals allowed him to celebrate milestones along the way, reinforcing his commitment to the journey. He regularly reminded himself of the compelling reasons behind his transformation—his family, his health, and his career—thus keeping his motivation alive. Journaling his progress and reflecting on his resilience helped to solidify his mindset and commitment, serving as a powerful reminder of how far he had come in his weight loss journey.

Inspiring Others Through his Weight Loss Journey

Garth Brooks understands the influence he holds as a public figure and has used his platform to inspire countless individuals on their own health journeys. By openly discussing his struggles and triumphs regarding weight loss, Brooks has created a ripple effect, encouraging fans to embrace their journeys toward better health. His transparency regarding the challenges he faced—such as emotional struggles with weight and the temptations of his celebrity lifestyle—resonates with many who battle similar issues.

Through interviews and social media engagement, Brooks shares valuable insights and tips, showcasing practical advice on nutrition and fitness. By providing encouragement and support to others, he demonstrates that anyone can strive for self-improvement, regardless of their starting point. His story is a beacon of hope, emphasizing that transformation takes time and patience, but with determination, it is entirely achievable.

Additionally, Garth’s influence is evident beyond just his words; he leads by example. His vibrant energy on stage post-transformation is a testament to the power of a healthy lifestyle. Fans not only witness his physical transformation but can also see the genuine happiness and confidence radiating from him. This positive energy serves to ignite motivation within individuals who aspire to transform their lives, compelling them to pursue their own health goals and make lasting changes that enhance their lives.The Honest Keto Diet Shark Tank Episode A Reality Check

Personal Reflections: The Impact of Transformation on Life and Career

Reflecting on his journey, Garth Brooks recognizes the profound impact that his transformation has had on both his personal life and career. The physical changes he experienced mirrored an inner evolution as well. Improving his physical health allowed him to appreciate life more fully, spend quality time with family and friends, and cherish moments that had previously felt overshadowed by self-doubt. This newfound perspective enhanced his overall outlook on life, fostering a deeper sense of gratitude for his career and the experiences it brings.

Professionally, Garth’s commitment to health has rejuvenated his passion for music and performing. His physical transformation has led to increased stamina on stage, empowering him to deliver electrifying performances that engage and captivate audiences. The positive feedback from fans fuels his motivation to maintain this lifestyle, creating a symbiotic relationship between his health choices and professional success. The joy he derives from performing is magnified, embodying the essence of a fulfilling career driven by personal wellness.

Perhaps most transformative has been Brooks’ ability to inspire others. By demonstrating that it is possible to make significant changes, he has cultivated a loyal following that admires his resolve. His journey instills hope in fans, encouraging them to embark on their own paths toward transformation. The ripple effects of his success in losing weight extend well beyond just personal achievements; they resonate within a community of individuals seeking to enhance their lives through healthier choices, proving the powerful impact that one person’s journey can have on many.

Embracing Health: A Legacy of Inspiration

Garth Brooks’ weight loss journey has been a remarkable tale of transformation that reflects the power of commitment and resilience. His story serves not only as an inspiration to his fans but also as a reminder that prioritizing one’s health is essential, regardless of life’s demands. The outcome of his hard work is evident in the strides he has taken both on and off the stage, continuing to evolve as an artist and a person while encouraging those around him to pursue their own wellness ambitions.

As Brooks continues to tour and create music, his focus on health remains a priority, setting a positive example for the generations to come. Through awareness campaigns and personal anecdotes, he advocates for healthier lifestyles, illustrating that taking care of oneself is a fundamental aspect of living a fulfilling life. This emphasis on health adds depth to his artistry, demonstrating the unity of physical and mental wellness within creative pursuits.

Ultimately, Garth Brooks has emerged not merely as a country legend but as a beacon of hope for those navigating their journeys toward health. Through his story, he cultivates a sense of community among fans striving for better health, reinforcing the idea that transformation is indeed within reach. As long as he continues to inspire and uplift those around him, Garth Brooks’ legacy will extend far beyond music, leaving an indelible mark on the hearts and minds of many aspiring to create their path to wellness.

Summary and Answers to Common Questions

Garth Brooks’ incredible journey toward health and transformation has not only reshaped his life but has also served as an inspiring narrative for countless individuals. Through an unwavering commitment to making healthier choices, Brooks found the strength to confront his challenges head-on, turning obstacles into opportunities for growth. As a public figure, he remains dedicated to spreading awareness about the importance of prioritizing health and encouraging others to make similar lifestyle changes. Thus, anyone interested in embarking on their own wellness journey can take invaluable lessons from Brooks’ experience.

A common question that arises regarding Garth’s journey is related to the specific methods he utilized for weight loss. While Brooks has not adhered to a one-size-fits-all diet, his focus has consistently been on balanced nutrition and regular exercise. Many individuals find success in tailoring their approach to fit their unique needs, much like Garth did. Implementing small, gradual changes to diet and incorporating physical activities in enjoyable ways can lead to significant results over time.

Another area of interest pertains to the mental challenges associated with weight loss. As Garth himself learned, emotional well-being plays a vital role in health transformation. Staying motivated amid challenges can prove to be a daunting task, but surrounding oneself with a supportive community and reflecting on personal goals can create a strong foundation for continued progress. The key lies in remembering that setbacks are merely part of the journey, and maintaining a proactive attitude is essential.

Additionally, individuals often inquire about how Brooks balances his demanding career with a commitment to health. As Garth has demonstrated, integrating wellness practices into everyday life can be seamless. Prioritizing nutrition and fitness need not be counterintuitive to a busy lifestyle; rather, planning meals and setting aside time for exercise can work harmoniously alongside professional commitments. Flexibility and creativity are invaluable tools for managing these competing demands.

In summary, Garth Brooks’ weight loss journey exemplifies a powerful narrative of transformation that transcends mere numbers on a scale. By embracing a holistic approach to health that integrates physical, emotional, and social elements, he highlights the possibility of true transformation. Regardless of one’s starting point, the pursuit of health is achievable for everyone willing to take the steps necessary for positive change. With determination, resilience, and a supportive community, the journey toward wellness can be a profoundly inspiring experience.

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Will Girling, pro cycling nutritionist for EF joins me to talk Ketogenic Diets and cycling. We discuss the benefits and downsides, plus supplements like HVMN Ketone Ester. Will the diet or supplements improve your performance and let you put out more power? Will's Website: https://willgirling.com/ Will's channel: https://www.youtube.com/user/williham68 Sources: https://doi.org/10.1016/0026-0495(83)90106-3 https://doi.org/10.1371/journal.pone.0235592 https://doi.org/10.1016/j.cmet.2016.07.010 https://doi.org/10.3389/fphys.2017.00806 https://doi.org/10.1152/ajpendo.00268.2005 https://doi.org/10.1152/japplphysiol.00813.2005 https://doi.org/10.1097/00005768-200201000-00014 https://doi.org/10.1249/MSS.0000000000002008 I've also set up a Patreon if you'd like to help support the channel for less than the price of a cup of coffee: https://www.patreon.com/franciscade the main GoPro mount i use!: https://www.prostandard.com/products/the-grill-mount the Low Down Axle mount i use: https://www.nut-r.co.uk/fc https://twitter.com/francis_cade https://www.instagram.com/francisccade LUTs - You can buy my LUT for $4 (or above) by becoming a supporter on Patreon here: https://www.patreon.com/franciscade BUY A T-SHIRT - https://www.jam-cycling.com/products/cade-pocket-tee MUSIC - I used Musicbed, FREE trial affiliate link here: http://share.mscbd.fm/Francisccade My bike insurance: https://www.pedalsure.com/ The following companies (that you'll see in my content) support me either financially or with free stuff, so huge thanks to these guys for helping the channel thrive: Attacus Cycling, Wilier Triestina, MET Helmets, Shimano, SkinGrowsBack, Hutchinson Tyres Pedalsure

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Understanding Lainey Wilson’s Motivations for Weight Loss Surgery

Lainey Wilson, a rising star in the music industry, has been a beacon of hope and inspiration for many. Known for her empowering songs and down-to-earth personality, she has also been open about her personal struggles, particularly concerning weight management. Lainey’s decision to explore weight loss surgery was influenced by her desire for health, personal well-being, and a more vibrant lifestyle. She understands that for many people, maintaining a healthy weight can be a significant challenge, often requiring a multi-faceted approach. This article delves deeply into her 3-step weight loss surgery journey, providing a thorough overview of her motivations, the surgical process, recovery, and the emotional and physical transformations that accompany such a life-altering decision.

In her professional life, Wilson has faced the pressures of conforming to industry standards, which often celebrate certain body types while overlooking others. This reality can create immense stress and shame for individuals who do not fit these molds. Lainey has repeatedly highlighted how societal expectations surrounding body image served as both a motivating factor and a source of frustration in her life. Thus, the decision to undergo weight loss surgery emerged not solely from a desire for a particular aesthetic but rather as a means to reclaim control over her health and confidence.

Moreover, weight loss surgeries are often regarded as a last resort for those who have struggled with diet and exercise alone. Lainey’s story is no different. After trying numerous weight loss methods with moderate success, she realized that she needed additional assistance to achieve her goals. Thus, embarking on this journey was an act of self-love, a step towards prioritizing her health and well-being, rather than succumbing to the pressures and expectations of the music industry. Each phase of her journey reflects a deep commitment to her holistic well-being.

The Pre-Surgery Preparation Phase

The journey towards weight loss surgery begins well before the actual procedure. Pre-surgery preparation is a crucial step that can determine the success of the operation and the patient’s long-term health outcomes. For Lainey Wilson, this phase encompassed a series of assessments, medical clearances, and emotional preparations. First and foremost, she underwent a meticulous evaluation by a team of healthcare professionals who reassessed her health status, medical history, and any potential risks associated with surgery. This comprehensive assessment ensured that she was a suitable candidate for the procedure.

In addition to physical evaluations, Lainey also engaged in consultations with nutritionists who provided valuable guidance on dietary modifications. They worked together to establish a meal plan that would not only help her shed those extra pounds but also set the foundation for a sustainable, healthy lifestyle post-surgery. This weight loss journey requires a commitment to long-term changes in eating habits rather than short-term fixes, a philosophy Lainey has embraced wholeheartedly.

Preparing mentally for surgery is as vital as addressing physical health. Emotional readiness can significantly impact the success of weight loss surgery. Lainey sought support from various sources: family, friends, and even professional counselors. This support network allowed her to openly discuss her fears, aspirations, and motivations, reinforcing her commitment to this life-altering decision. By the time she approached the surgery date, Lainey had a solid understanding of what would happen next, both physically and emotionally. She recognized that this journey was not solely about losing weight; it was about fostering a healthier lifestyle that would enhance her overall quality of life.

Experiencing the Surgery: What it Entailed

The moment of the surgery itself is often filled with a mix of excitement and anxiety. For Lainey Wilson, the actual procedure was a remarkable turning point in her weight loss journey. Choosing a minimally invasive approach, Lainey opted for a laparoscopic method, a procedure that typically features shorter recovery periods and fewer complications. Under the care of a qualified surgical team, the operation focused on altering her digestive system to promote weight loss—either through gastric bypass or sleeve gastrectomy, depending on specific health indicators and recommendations.

Throughout the surgery, Lainey received close supervision from the medical staff, ensuring a safe and comfortable experience. Post-surgery, she was monitored carefully as she transitioned into recovery. Understanding the importance of medical oversight, she adhered closely to the postoperative protocols established by her healthcare providers. This included a period of rest followed by a gradual reintroduction of solid foods, beginning with liquids to ease her body into the new dietary requirements.

Despite the many challenges that accompany any surgical procedure, Lainey remained upbeat and determined. Emphasizing the importance of community, she attracted support from her fans through social media, sharing updates about her recovery journey. This openness not only helped her process the physical changes taking place but also fostered a connection with her audience, transforming her personal story into an empowering narrative that resonates with many facing similar challenges. By maintaining transparency about her experience, Lainey showcased the human side of weight loss surgery, revealing the inner strength required to navigate this path.

Navigating the Recovery Phase

Recovery after weight loss surgery is a multifaceted process, encompassing physical, emotional, and social aspects. For Lainey Wilson, this phase required patience and a mindful approach to her lifestyle changes. Initially, she faced physical limitations, struggling with basic tasks and adapting to her new diet. This adjustment period was essential, teaching her how to listen to her body and understand its responses to the significant changes initiated by the surgery. Through monitoring portion sizes and being conscious of food choices, Lainey slowly learned how to navigate her new relationship with food.

Emotional recovery was equally important, as Lainey confronted moments of frustration and self-doubt. Alongside the physical transformations, emotional shifts were bound to occur. Her self-image was in flux, and she had to navigate the complexities of changing perceptions, both from herself and society. During this challenging time, she leaned heavily on her support network—friends, family, and mental health professionals—who provided the encouragement needed to stay resolute during her journey.

As Lainey progressed in her recovery, she began to experience the benefits of her surgery, both physically and mentally. The initial losses on the scale instilled a sense of accomplishment and motivation to continue pursuing a healthier lifestyle. Engaging in physical activities that she previously found challenging became enjoyable, allowing Lainey to embrace a more active and fulfilling routine. This newfound vitality slowly shifted the narrative around who she is, creating a positive feedback loop that encouraged further growth. Lainey’s journey exemplifies how recovery can lead to rediscovery and renewal, offering insights into the importance of nurturing both the body and the mind after such a monumental change.

Celebrating the Transformation and Continuous Improvement

The transformation that Lainey Wilson underwent following weight loss surgery was not merely a physical change; it was an awakening. As the months progressed, she noticed a significant shift in her energy levels, outlook on life, and overall well-being. No longer burdened by the same constraints, Lainey discovered a plethora of opportunities to pursue her passion for music in new and dynamic ways. This renewed enthusiasm was palpable, both personally and professionally, as she began to engage more with her fans and the public, inspiring many with her story.

Practicing self-love and acceptance became central themes for Lainey as she continued her journey. Throughout this phase, she made it a point to celebrate every small victory, from fitting into a pair of jeans that hadn’t fit in years to completing a previously daunting hike. Acknowledging these milestones was crucial in sustaining her motivation and reinforcing her commitment to a healthier lifestyle. Lainey’s emphasis on celebration serves as a reminder that weight loss journeys should be marked not only by numbers on a scale but by the profound changes in perspective and self-worth.

Looking beyond her initial transformation, Lainey remains committed to continuous improvement. She understands that weight loss surgery is not a quick fix but rather a stepping stone towards a healthier life. Maintaining open communication with healthcare providers, she commits to regular check-ups and nutritional guidance. Additionally, she shares her ongoing efforts with her audience, reinforcing the importance of community support in achieving lasting change. Lainey Wilson’s journey resonates deeply, showcasing the resilience of the human spirit and the dedication it takes to overcome challenges and emerge victorious.

Reflecting on a Journey: Summary and Q&A

Lainey Wilson’s journey through weight loss surgery illustrates not only the physical changes that can occur through medical intervention but also the emotional and mental transformations that accompany such a colossal life change. From her initial motivations to the rigorous preparation, surgery, and recovery, each step of her journey serves as a testament to resilience, perseverance, and the pursuit of holistic well-being. In sharing her story, Lainey continues to inspire countless others who face similar struggles, proving that change is indeed possible when one dedicates themselves to their health.

For those contemplating similar paths, several questions frequently arise. One of the most important questions is whether weight loss surgery is the right choice: it is essential to consult with qualified healthcare professionals and assess individual health conditions before making a decision. Another common question involves the type of procedure to be pursued—considerations include the specific health situation, desired outcomes, and personal preference. Education around these choices can significantly influence long-term success.

The emotional aspect is also critical, as individuals often grapple with feelings of anxiety and fear regarding surgery and recovery. Finding a strong support system can alleviate some of these struggles; connecting with others who have undergone similar experiences can provide valuable insights and encouragement. Lastly, many wonder about the long-term impacts of weight loss surgery on mental health, nutrition, and lifestyle. While there may be challenges along the way, long-lasting transformation is possible through dedication, guidance, and a focus on holistic health. Lainey Wilson’s journey encapsulates not just the possibility of change but also the power of community and self-acceptance.

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Investigation on the Effects of GLP1 analog and SGLT2 inhibitor against Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms Background: The present study investigated the possible cardioprotective effects of GLP1 and SGLT2i against diabetic cardiomyopathy (DCM) in type 2 diabetic rats and the possible underlying mechanisms. DCM is defined as the presence of heart failure in absence of coronary artery disease. Methods: Thirty-two male Sprague Dawley rats were randomly subdivided into 4 equal groups; a) control group, b) DM group, type 2 diabetic rats with saline daily for 4 weeks, c) DM+ GLP1, as DM group with GLP1 analogue (liraglutide) at a dose of 75 µg/kg for 4 weeks, and d) DM+ SGLT2i: as DM group with SGLT2 inhibitor (dapagliflozin) at a dose of 1mg/kg for 4 weeks. By the end of treatment (4 weeks), serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB) were measured. Also, the cardiac histopathology, myocardial oxidative stress markers (MDA, GSH and CAT) and norepinephrine (NE), myocardial fibrosis, the expression of caspase-3, TGF-, TNF- and tyrosine hydroxylase (TH) in myocardial tissues were measured. Results: T2DM caused significant increase in serum glucose, HOMA-IR, serum CK-MB and LDH (p less than 0.05). Also, DM caused significant myocardial damage and fibrosis, elevation of myocardial MDA, NE with upregulation of myocardial caspase-3, TNF-, TGF- and TH and significant decrease in serum insulin and myocardial GSH and CAT (p less than 0.05). Administration of either GLP1 analog and SGLT2i caused in significant improvement in all studied parameters (p less than 0.05). Conclusion: We concluded that either of GLP1 and SGLT2i exhibited cardioprotective effects against DCM in T2DM with the upper hand for SGLT2i. This might be due to attenuation of fibrosis, oxidative stress, apoptosis (caspase-3), sympathetic nerve activity and inflammatory cytokines (TNF- and TGF-). #type #2 #cardiomyopathy #oxidative #stress #3 #glp1 #norepinephrine #tgf #tnf #and #tyrosine