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Text us to let us know what you want to hear on the podcast! (https://www.buzzsprout.com/twilio/text_messages/2363160/open_sms) In this episode of Reality Check with Jess and Jill, we’re diving into the real story behind GLP-1 medications with Dr. Pacha, a Board-Certified physician in Internal Medicine, Gastroenterology, Hepatology, and Nutrition. If you’ve been wondering how these meds work, why so many people regain weight after stopping them, or what they mean for long-term health, this conversation will is SO enlightening (and might even change your perspective). We covered: • Why muscle loss is a real risk with GLP-1s and how to get better results (and kep them) • How to move beyond just the medication and build sustainable habits that stick for life (and not rely on the medication forever) • The risks these meds can pose for women, including how they interact with hormonal birth control • Dr. Pacha's take on the future of GLP-1s What we loved most about this episode is Dr. Pacha’s commitment to collaboration. He truly understands that real results come from blending medical expertise with functional health and behavior change - a philosophy that aligns perfectly with Fueled’s approach of "where function meets physique." This episode is full of powerful takeaways and refreshing perspective. Hit play, take some notes, and then go give Dr. Pacha a follow on Instagram at www.instagram.com/drgymgems ... you’ll be glad you did! We'd love to hear your thoughts & feedback. DM us on Instagram with topic requests or just to connect! ----------------------------------------------------------------------------- Apply for 1:1 coaching (https://www.fueledcoaching.co/coaching) Partner with us to support your weight loss clinic (https://www.fueledcoaching.co/partnerships) Grab your free Metabolism Reset Guide here (https://www.fueledbybalance.com/opt-invuz7urpr) Nuethix (https://wwww.nuethix.com/) discount: JILLIAN ----------------------------------------------------------------------------- FOLLOW US ON SOCIAL MEDIA! Jillian: www.instagram.com/jillianrfit (https://www.instagram.com/jillianrfit) Jess: www.instagram.com/jesserefit (https://www.instagram.com/jesserefit) Fueled: www.instagram.com/fueledby.balance (https://www.instagram.com/fueledby.balance) Reality Check: www.instagram.com/realitycheck_fitpodcast (https://www.instagram.com/realitycheck_fitpodcast) Jillian's TT: www.tiktok.com/@jillianrfit (https://www.tiktok.com/@jillianrfit) For free resources & a community of thousands of women, join our free group, Macro Tracking & Hormone Health for Women her... (https://www.facebook.com/groups/423815799171926)

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Neil Iyengar, MD, Memorial Sloan Kettering Cancer Center, New York, NY, comments on the impact of lifestyle interventions and retrospective analyses on various outcomes in breast cancer survivors. Dr Iyengar highlights that weight management therapies, such as nutrition counseling, bariatric surgery, or weight loss drugs, can lower the rates of cardiovascular events in breast cancer survivors, but notes that only a small percentage of patients receive such therapies. Dr Iyengar also discusses the potential for using genetic markers to predict AI-induced musculoskeletal toxicity and the importance of identifying patients at high risk for weight gain or nutritional risk through the use of EPRO instruments. This interview took place at the 2024 San Antonio Breast Cancer Symposium (SABCS) congress in San Antonio, TX. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

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Recently, there has been significant excitement in the medical community surrounding a new drug called Semaglutide. Originally approved by the FDA for the treatment of type 2 diabetes, Semaglutide has garnered attention for its potential off-label use as a weight loss medication. Many individuals struggling with obesity have been eager to try Semaglutide as a way to help them shed unwanted pounds. But is Semaglutide FDA approved for weight loss? Understanding the approval process can provide insight into this important question.

History of Semaglutide Approval

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that was first approved by the FDA in 2017 for the treatment of type 2 diabetes. It works by mimicking the effects of a hormone produced in the intestines that helps regulate blood sugar levels. Patients with diabetes who take Semaglutide typically experience improved blood sugar control and may also see weight loss as a secondary benefit.

In 2021, Semaglutide was approved by the FDA for use in higher doses specifically for weight management in individuals with obesity or overweight who have at least one weight-related comorbidity, such as hypertension or type 2 diabetes. This approval marked a significant milestone in the fight against obesity, as Semaglutide is one of the first drugs to be approved by the FDA for this specific indication.

Mechanism of Action

Semaglutide works by activating GLP-1 receptors in the brain, which helps regulate appetite and food intake. It also slows down the emptying of the stomach, leading to a feeling of fullness that can help individuals consume fewer calories. Additionally, Semaglutide has been shown to improve insulin sensitivity and increase the body’s utilization of glucose, which can aid in weight loss and improve overall metabolic health.





Studies have demonstrated that individuals taking Semaglutide for weight management have experienced significant reductions in body weight compared to those taking a placebo. In clinical trials, participants lost an average of 15-20% of their body weight over a period of several months, making Semaglutide a promising option for individuals struggling with obesity.

Side Effects and Considerations

Like any medication, Semaglutide is not without risks. Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects typically subside over time as the body adjusts to the medication. In rare cases, Semaglutide has been associated with more serious side effects such as pancreatitis and gallbladder disease, so it is important for individuals considering this medication to weigh the potential risks and benefits.

It is essential for individuals taking Semaglutide for weight loss to also make lifestyle changes such as adopting a healthy diet and increasing physical activity. Semaglutide is most effective when used in conjunction with a comprehensive weight management program that includes behavior modification and counseling. It is not a magic pill, but rather a tool that can support individuals in their weight loss journey.

Conclusion

In conclusion, Semaglutide is indeed FDA approved for weight loss in individuals with obesity or overweight who have weight-related comorbidities. Understanding the approval process and mechanism of action of Semaglutide can help individuals make informed decisions about whether this medication is right for them. It is important to consult with a healthcare provider before starting Semaglutide or any other weight loss medication to ensure that it is safe and appropriate for your individual health needs.

Overall, Semaglutide represents a promising option for individuals struggling with obesity, offering a new tool in the fight against this chronic and challenging condition. With proper guidance and support, Semaglutide may help individuals achieve long-term weight loss and improve their overall health and well-being.

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00:00 - Intro 00:24 - How to Get GLP-1 Drugs Covered by Employer Health Insurance 03:10 - CVS Drops Zepbound Coverage: Weight Loss Patients Face New Challenges 08:21 - Insurance Changes for GLP-1 Weight Loss Drugs: What Patients Need to Know 11:36 - Wegovy and Zepbound: Price Drops and Access Challenges 1. How to Get GLP-1 Drugs Covered by Employer Health Insurance In this video, we explore the challenges and solutions for getting GLP-1 medications covered by employer health insurance. Learn about the current landscape of obesity treatments, the impact of drug pricing in the U.S., and how employers can make these essential medications more accessible. We discuss the importance of GLP-1 drugs in combating obesity and cardiometabolic diseases, and what steps can be taken to improve coverage and affordability for employees. Join us for insights from healthcare experts and real-life stories. 2. CVS Drops Zepbound Coverage: Weight Loss Patients Face New Challenges CVS Caremark has stopped coverage for the popular weight loss drug Zepbound, impacting thousands of patients relying on GLP-1 medications for obesity treatment. In this video, we break down why CVS made this decision, how it affects insurance coverage for drugs like Zepbound and Wegovy, and what options remain for patients. Learn about the cost-saving rationale behind the move, Eli Lilly's response with their self-pay program, and expert opinions on the risks of switching medications mid-treatment. We also discuss the role of pharmacy benefit managers (PBMs) in drug pricing, the debate over high list prices set by manufacturers, and the broader implications for healthcare access. Stay informed on medical necessity exceptions, alternative pathways for obtaining Zepbound, and the ongoing battle between drug manufacturers and PBMs over prescription costs. 3. Insurance Changes for GLP-1 Weight Loss Drugs: What Patients Need to Know Major changes in insurance coverage for GLP-1 drugs like Zepbound and Wegovy are affecting patients managing obesity. CVS Caremark is removing coverage for Zepbound, forcing many individuals to either pay out-of-pocket or switch medications. This video explores the impact of these changes on patients, potential health risks, and what options are available for those affected. Learn about the differences between GLP-1 medications, the trial-and-error process, and how you can navigate this challenging situation. Stay informed about your healthcare rights and alternatives as we break down the latest developments in weight loss drug coverage. 4. Wegovy and Zepbound: Price Drops and Access Challenges In this video, we explore the recent price drops of popular obesity medications Wegovy and Zepbound. Despite the decrease in costs, access to these drugs remains a significant challenge for many patients. We discuss the implications of insurance coverage, the role of employers, and the impact of pharmacy benefit managers. Learn about the future of obesity treatments, including potential pill versions and the effects of competition on pricing. Join us as we delve into the complexities of accessing these essential medications.

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