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Our full interview with Deborah Evans. We spoke to Deborah Evans about GLP-1 receptor agonists – the fat jabs – and what we have learned over the past 12-18 months. Read, watch and listen here - https://medicalupdateonline.com/2025/03/glp-1-ras-where-are-we-now-what-have-we-learned/?utm_source=youtube&utm_medium=social&utm_campaign=organic Register on our website for news straight to your inbox - https://medicalupdateonline.com/register/ This episode of ‘In Discussion With’ is also on Spotify. Listen to the full podcast now - https://creators.spotify.com/pod/show/medicalupdateonline/episodes/GLP-1-RAs--where-are-we-now--What-have-we-learned-e300s0f 0:00 - Introduction, titles & roles 1:24 - Are GLP-1 RAs easy & safe for weight loss? 3:08 - Differences - semaglutide vs. tirzepatide 6:31 - Side-effects of GLP-1 RAs 8:33 - Serious side-effects of GLP-1 RAs 10:07 - How to get GLP-1 RAs 12:27 - GLP-1 RAs via the NHS 14:54 - Additional support for patients 16:03 - Incorrect GLP-1 RA prescribing 18:02 - Counterfeit GLP-1 RAs 19:37 - Short-term use of GLP-1 RAs? 24:06 - Should you take GLP-1 RAs for life? 25:12 - Risks of sarcopaenia and osteoporosis 28:19 - Dose optimisation 30:34 - Tolerability variations 31:24 - Dose individualisation 33:20 - GLP-1 RA drug switching 35:58 - GLP-1 RA non-responders 37:24 - Starting GLP-1 RAs – what to expect 40:02 - Do we eat too much? 42:39 - Value of GLP-1 RA weight loss 43:56 - Possible anaesthetic risk 46:49 - Outro This interview was recorded on 06/02/2025. ___ Keep up to date with us across our network; Email us at - [email protected] Site - https://medicalupdateonline.com/ Twitter - https://twitter.com/medupdateon1ine Instagram - https://www.instagram.com/medicalupdateonline Facebook - https://www.facebook.com/medupdateonline LinkedIn - https://www.linkedin.com/company/medicalupdateonline This content is for informational purposes only, and does not replace the advice of your own doctor or healthcare professional. Copyright © 2022 MedicalUpdateOnline. IMI (a trading name of ICR UK Limited) is a digital communications agency that specialises in the pharmaceutical and medical industries. IMI was founded in 2003 by the current CEO Peter Mas-Mollinedo, a pharmacist and forward-thinking entrepreneur. IMI’s primary activities include the production of medical educational journals and bulletins, medical conference coverage and video interviewing of health care professionals worldwide to disseminate information such as trial results, new products, research, drug approvals, new accreditations, etc. It is a trusted provider of medical information to its extensive database of medical health care professionals in the UK, Europe and beyond. To find out more about IMI, please see our websites www.medicalupdateonline.com and www.medicalimi.com. Alternatively, you can email us at [email protected].

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Semaglutide, a medication commonly used to treat type 2 diabetes, has gained attention in recent years for its potential to help with weight loss. One of the popular options is the use of semaglutide for weight loss. While the drug has been shown to be effective at helping people shed pounds, finding the optimal dose for weight loss can be a bit tricky. In this article, we will explore the optimal semaglutide weight loss dose and what you should know about it.

Understanding Semaglutide for Weight Loss

Semaglutide is a GLP-1 receptor agonist, which means that it works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 is released in response to food intake and helps to regulate blood sugar levels by stimulating insulin secretion and reducing glucagon secretion. In addition to its effects on blood sugar, GLP-1 also helps to regulate appetite and promote weight loss.

Studies have shown that semaglutide can help people lose weight by reducing appetite, slowing stomach emptying, and increasing feelings of fullness. As a result, people taking semaglutide tend to eat less and therefore consume fewer calories, leading to weight loss over time.

When it comes to using semaglutide for weight loss, finding the right dose is key. The optimal dose can vary depending on individual factors such as age, weight, and overall health. Your healthcare provider will work with you to determine the most effective dose of semaglutide for your weight loss goals.

Factors to Consider

There are several factors that your healthcare provider will consider when determining the optimal dose of semaglutide for weight loss. These include your starting weight, any pre-existing medical conditions you may have, and whether you have any other medications that could interact with semaglutide. Your healthcare provider will also take into account your overall health goals and lifestyle factors when prescribing semaglutide.

It’s important to follow your healthcare provider’s instructions carefully when taking semaglutide for weight loss. The medication should be taken as prescribed, and you should attend regular follow-up appointments to monitor your progress. Your healthcare provider may also recommend incorporating healthy eating and regular physical activity into your weight loss plan to maximize the effects of semaglutide.

While semaglutide can be an effective tool for weight loss, it is not a magic solution. It is important to manage your expectations and understand that weight loss takes time and effort. Semaglutide should be used as part of a comprehensive weight loss plan that includes healthy lifestyle changes for the best results.

Potential Side Effects

Like any medication, semaglutide can cause side effects in some people. Common side effects of semaglutide may include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to improve over time as your body adjusts to the medication. If you experience severe or persistent side effects while taking semaglutide, be sure to contact your healthcare provider.

In rare cases, semaglutide may cause more serious side effects such as pancreatitis or thyroid tumors. It’s important to be aware of the potential risks associated with semaglutide and to notify your healthcare provider if you experience any unusual symptoms while taking the medication. Your healthcare provider will be able to provide guidance on how to manage any side effects and whether it is safe to continue taking semaglutide for weight loss.





In conclusion, the optimal semaglutide weight loss dose can vary depending on individual factors, and it is important to work closely with your healthcare provider to find the right dose for you. Semaglutide can be an effective tool for weight loss when combined with healthy lifestyle changes, but it is not a magic solution. By following your healthcare provider’s instructions and monitoring your progress, you can achieve your weight loss goals with semaglutide.