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We were honored to host Professor Robert Lustig, MD, at Emery Pharma once again. Dr. Lustig, a renowned Pediatric Endocrinologist from UCSF, delivered an insightful presentation on the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and its critical links to metabolic dysfunction. Below are the key highlights from his talk: Non-Alcoholic Fatty Liver Disease (NAFLD) Overview NAFLD impacts 45% of Americans and 25% of the global population, often going undetected until complications arise. Once primarily associated with alcohol use, NAFLD is now prevalent in children, largely due to dietary factors like sugar consumption. Key Points from Dr. Lustig's Talk Core Arguments Fat and Metabolic Disease: Obesity is a risk factor but not the direct cause of metabolic diseases like type 2 diabetes and NAFLD. Internal fat distribution (e.g., visceral and liver fat) rather than subcutaneous fat plays a critical role, even in individuals with normal BMI. Fructose as a Toxin: Fructose, found in sugar and processed foods, overwhelms liver mitochondria, driving fat production (de novo lipogenesis). The liver damage caused by fructose is similar to that caused by alcohol, though without affecting the brain. Inflammation and Oxidative Stress: Fructose accelerates oxidative stress and inflammation, contributing to liver fat accumulation, insulin resistance, and type 2 diabetes. Three-Hit Hypothesis: NAFLD arises from three factors: Mitochondrial dysfunction causing fat buildup. Reactive oxygen species (ROS) leading to inflammation. Malnutrition impairing the liver's ability to export fat. Interventions: Addressing dietary quality, particularly by reducing sugar intake, is more effective than focusing solely on weight loss. While exercise and balanced nutrition help, drugs targeting NAFLD are still experimental. Key Data Points Children and NAFLD: 25% of children with type 2 diabetes have a normal BMI, underscoring the impact of diet over obesity alone. Fructose Restriction Study: Replacing fructose with glucose in obese children significantly reduced liver fat and metabolic syndrome markers without weight loss. Comparison to Alcohol: Fructose causes liver damage through similar pathways as alcohol, though it does not affect the brain. Call to Action Dr. Lustig urged for a shift toward reducing sugar consumption as a public health priority, emphasizing that fixing the food supply and curbing processed food consumption is critical to tackling metabolic diseases. Q&A Highlights Dr. Lustig discussed the limitations of GLP-1 agonists, noting their high cost, limited access, and failure to address the root causes of metabolic dysfunction. He reinforced that dietary quality, particularly reducing fructose and processed foods, plays a more significant role in combating these conditions than fat content. Closing Remarks Dr. Lustig emphasized the urgent need for systemic changes in food policies to prevent diseases associated with poor nutrition. He advocated for education and significant reductions in sugar intake as primary strategies to improve public health. To watch the full video of Dr. Lustig’s presentation, click here: https://youtu.be/oIWRmOIR_CM. To access the curated playlist of all Professor Lustig’s talks at Emery Pharma, click here: https://www.youtube.com/playlist?list=PLlTSLi3qD78edU0aWyV8x9yLMIS-FC2fv.
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OneShot Keto’s Memorable Episode: Shark Tank’s Ketogenic Spotlight
OneShot Keto, a popular weight loss supplement, made headlines with its memorable appearance on the hit television show Shark Tank. The episode showcased the power of the ketogenic diet and how OneShot Keto can help individuals achieve their weight loss goals. The product’s innovative formula and compelling pitch caught the attention of the sharks, leading to a heated bidding war. Let’s dive into the details of this unforgettable episode and explore how OneShot Keto became a household name in the world of health and wellness.
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The Pitch
During their presentation on Shark Tank, the creators of OneShot Keto shared their personal struggles with weight loss and how the ketogenic diet transformed their lives. They explained the science behind the keto diet and how OneShot Keto enhances the body’s natural fat-burning processes. The sharks were impressed by the before-and-after photos of individuals who had successfully used the product to lose weight and improve their overall health.
OneShot Keto’s founders emphasized the unique blend of ingredients in the supplement, which includes BHB (Beta-Hydroxybutyrate) ketones. These exogenous ketones help the body enter a state of ketosis, where it burns fat for fuel instead of carbohydrates. The sharks were intrigued by the potential of OneShot Keto to help people achieve rapid weight loss without sacrificing their energy levels or mental clarity. The founders also highlighted the convenience of taking OneShot Keto in capsule form, making it easy to incorporate into daily routines.
The Bidding War
As the presentation came to a close, the sharks were eager to get in on the action. They recognized the growing popularity of the ketogenic diet and saw OneShot Keto as a valuable investment opportunity. The bidding war began, with each shark making compelling offers to secure a deal with the creators of OneShot Keto. The tension in the room was palpable as the founders weighed their options and considered the sharks’ proposals.
Ultimately, a deal was struck with one of the sharks, propelling OneShot Keto to even greater success. The partnership provided the resources and expertise needed to expand the reach of the product and bring it to a wider audience. Fans of Shark Tank were inspired by OneShot Keto’s journey from humble beginnings to nationwide acclaim, proving that with dedication and innovation, anything is possible.
The Aftermath
Following its appearance on Shark Tank, OneShot Keto experienced a surge in demand as viewers rushed to try the supplement for themselves. The positive reviews and testimonials poured in, with many customers reporting significant weight loss and improved overall health. OneShot Keto’s presence on Shark Tank solidified its reputation as a trusted and effective weight loss solution, propelling it to the top of the market.

Today, OneShot Keto continues to help individuals around the world achieve their weight loss goals and live healthier, more vibrant lives. The product’s commitment to quality, innovation, and customer satisfaction sets it apart in a crowded market, making it a standout choice for those looking to transform their bodies and reclaim their confidence. With its unforgettable debut on Shark Tank, OneShot Keto has cemented its status as a leader in the ketogenic supplement industry.
Summary:
OneShot Keto’s appearance on Shark Tank was a defining moment for the ketogenic supplement industry, showcasing the power of the keto diet and the effectiveness of the product. The memorable pitch, intense bidding war, and subsequent success of OneShot Keto have solidified its reputation as a trusted weight loss solution. With its innovative formula and commitment to customer satisfaction, OneShot Keto continues to help individuals achieve their weight loss goals and live healthier lives.
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Welcome to Episode #4 of the Cerebellum Podcast. A podcast that helps simplify health into actionable steps through digestible episodes. In this episode, Josh discusses: - How to optimize your nutrition for fat-loss For more content like this, follow us on our social media below: Instagram: @cerebellumcoaching Thanks for watching! #cerebellum #health #longevity #nutrition #fitness #workout
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