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Several weeks ago, we briefly talked about oral semaglutide (Rybelsus) when we addressed the current concern surrounding the Wegovy shortage. And although it's currently not approved for weight loss, there is a lot buzz surrounding the hope that it soon will be, and its clinical results for weight loss have been promising. But remember, you can't always believe what you read unless there's science to back it up. Today I'd like to talk about oral semaglutide, the current clinical studies surrounding its efficacy for weight loss, and things to consider with oral weight loss medications. What is Rybelsus? We've talked about Rybelsus before. It's the oral version of semaglutide. It contains the same active ingredient as Ozempic and Wegovy. Because all three of these medications have the same active ingredient, they work the same way in your body. After you eat a meal, semaglutide helps to lower your blood sugar by mimicking a gut hormone called glucagon-like peptide-1 (GLP-1). This causes your pancreas to release insulin and blocks your liver from releasing sugar. It also slows down how quickly food leaves your stomach. This makes you feel full longer and suppress your appetite. All of these things together lead to weight loss. The most obvious difference between the medications is how they're taken. Wegovy and Ozempic are once weekly injections, while Rybelsus is a pill you have to take by mouth every day. Like Ozempic, Rybelsus is not approved for weight loss management even though loss of appetite may occur. Currently, Rybelsus should only be used to treat type 2 diabetes. It's also important to remember that Rybelsus comes in 3mg, 7mg, and 14mg strengths. Only patients taking the Ozempic 0.5mg dose for type 2 diabetes can switch to Rybelsus. And, like Wegovy and Ozempic, Rybelsis can also cause similar stomach-related side effects like nausea, vomiting, diarrhea, and constipation. What do the clinical studies show? A 68-week study with almost 670 adult participants reported an average weight loss of nearly 15% taking oral semaglutide 50mg daily. The placebo group lost an average of 2.4% of their body weight. This is similar to the results from the largest Wegovy trial (2,000 adult participants), which showed about 15% average weight loss within the same time period. Things to consider Higher doses: The Rybelsus doses studied for weight loss were 50 mg daily. Currently, Rybelsus comes in 3mg, 7mg, and 14mg strengths. The manufacturer plans to request FDA approval for the 50mg dose if approved for weight loss. Convenience: The tablets must also be taken first thing in the morning with no more than 4 ounces of water. You must wait 30 minutes before eating, drinking, or taking other medications to absorb the Rybelsus fully. Initially, injections may seem scary, but with some practice, giving yourself a shot under the skin can be painless. Often the needles used for subcutaneous injections are as thin as two strands of hair. Would you rather give yourself a weekly injection or remember to take a daily pill? Heart benefits: Rybelsus is great for people with type 2 diabetes who don't want to give themselves injections. However, unlike Ozempic and Wegovy, Rybelsus doesn't have the same heart-related benefits (lower risk of heart attack and stroke). In fact, studies have shown to lower the risk of death due to heart problems in certain people by 26%. Medication Interactions: Rybelsus has been shown to lower the absorption of levothyroxine (a thyroid medication) by 33%. Make sure to let your healthcare provider know your full list of medications so they can check for potential drug interactions while taking Rybelsus. Cost: The average cash price (without prescription insurance) of Rybelsus is $1,100 for 30 tablets (3mg, 7mg, or 14mg tablets). This is lower than the average cash price of Wegovy which is about $1,500 for 4 prefilled pens. Price tags on these weight loss medications don't come cheap and, without the help of insurance, are out of reach for many. I don't anticipate the price for 50 mg Rybelsus tablets to be much better. It will likely have a similar cash price of around $1,000-1,1500 for 30 tablets. Thanks again for listening to The Peptide Podcast, we love having you as part of our community. You can find out more information about semaglutide on our previous podcasts. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! Pro Tips We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness? Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier.

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Are you looking for a convenient way to incorporate apple cider vinegar (ACV) into your ketogenic diet? Look no further than Truly Keto ACV Gummies! These tasty gummies are a convenient and delicious way to reap the benefits of ACV while staying on track with your keto lifestyle. In this article, we will delve into user feedback and results to help you determine if Truly Keto ACV Gummies are right for you.Walking At Disney To Lose Weight

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Many users have reported positive experiences with Truly Keto ACV Gummies. One user, Sarah, shared that she struggled to take traditional ACV due to its strong taste and odor. However, she found that Truly Keto ACV Gummies were much more palatable and easier to incorporate into her daily routine. Sarah noticed improved digestion and energy levels after regularly taking the gummies.

Another user, John, experienced a reduction in bloating and indigestion after adding Truly Keto ACV Gummies to his diet. He also mentioned that the gummies helped curb his sugar cravings, which was a significant benefit for maintaining his keto diet. John found that the gummies were a convenient way to get his daily dose of ACV without any hassle.

Overall, user feedback for Truly Keto ACV Gummies has been overwhelmingly positive. Many users appreciate the convenience and taste of the gummies, as well as the benefits they have experienced while taking them. If you’re looking for a simple and enjoyable way to incorporate ACV into your keto diet, Truly Keto ACV Gummies may be worth a try.

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In addition to the positive user feedback, many individuals have reported tangible results from taking Truly Keto ACV Gummies. One user, Emily, shared that she noticed a decrease in her appetite and cravings for unhealthy snacks after incorporating the gummies into her daily routine. This reduction in appetite helped Emily stay on track with her keto diet and reach her weight loss goals.

Another user, Mark, experienced an increase in his energy levels and mental clarity after taking Truly Keto ACV Gummies consistently. Mark found that the gummies helped him power through his workouts and stay focused throughout the day. He also noticed improvements in his skin complexion, which he attributed to the detoxifying effects of ACV.

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Jonah Hill has been a well-known figure in Hollywood for years, both for his acting chops and his distinctive appearance. Over the years, he has gained and lost weight, with his weight fluctuations often making headlines in the media. However, in recent years, Jonah Hill has undergone a significant transformation, shedding pounds and embracing a healthier lifestyle. His weight loss journey is not just about physical changes but also about self-acceptance and personal growth.

The Beginning of Jonah Hill’s Weight Loss Journey

Jonah Hill first gained prominence in the early 2000s for his comedic roles in movies like “Superbad” and “Knocked Up.” He quickly became known for his larger-than-life personality and his willingness to poke fun at himself. However, as his career began to take off, Jonah Hill’s weight became a constant source of criticism and scrutiny. Despite this, he continued to embrace his unique sense of style and humor, refusing to conform to Hollywood’s narrow standards of beauty.

As Jonah Hill’s career continued to soar, so did his weight. He struggled with his physical appearance and the pressures of fame, often turning to food for comfort. However, in 2011, Jonah Hill made a decision that would change his life forever. He embarked on a weight loss journey that would not only transform his body but also his mindset and outlook on life.

Commitment to Health and Wellness

Jonah Hill’s weight loss journey was not easy. He had to make significant lifestyle changes, including adopting a healthier diet and exercise routine. He began working with trainers and nutritionists to develop a plan that would help him reach his goals in a sustainable way. Jonah Hill also opened up about his struggles with body image and self-esteem, inspiring others to embrace their imperfections and prioritize their health.

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Over time, Jonah Hill’s dedication to his health and wellness paid off. He started to see results, both physically and mentally. He gained confidence in himself and his abilities, learning to love and accept himself for who he was. Jonah Hill’s weight loss was not just about shedding pounds; it was about reclaiming his identity and living life on his own terms.

Embracing Self-Acceptance and Transformation

Through his weight loss journey, Jonah Hill learned valuable lessons about self-acceptance and transformation. He realized that true happiness comes from within, not from external validation or approval. Jonah Hill’s journey taught him to prioritize his well-being and happiness above all else, inspiring others to do the same.

Today, Jonah Hill continues to be a role model for self-acceptance and transformation. He has come a long way from his early days in Hollywood, evolving into a confident and empowered individual. Jonah Hill’s weight loss journey serves as a powerful reminder that change is possible, no matter where you start or how far you have to go.

FAQs about Jonah Hill’s Weight Loss

Q: How much weight did Jonah Hill lose?
A: Jonah Hill has not disclosed the exact amount of weight he lost, but he has visibly slimmed down over the years.

Q: What motivated Jonah Hill to lose weight?
A: Jonah Hill’s motivation to lose weight came from a desire to prioritize his health and well-being, as well as to challenge societal standards of beauty and acceptance.

Q: Has Jonah Hill spoken about his weight loss journey?
A: Yes, Jonah Hill has been open about his struggles with weight and body image, sharing his journey to inspire others to embrace self-acceptance and transformation.

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Today, we dive deep into the multifaceted world of weight loss. Dr. Rukmini Rednam sits down with Erin Ho to discuss the complexities of weight loss medications, the importance of personalized care, and the role lifestyle changes play in sustainable weight management. From the pros and cons of medications like semaglutide and tirzepatide to the consequences of rapid weight loss on facial aging and muscle mass, this episode covers it all. We'll also explore the psychological triggers of snacking, the societal pressures of body image, and the essential balance of medical procedures with self-care.  Join us as we unravel the science, the stigma, and the strategies to achieving long-term success in weight management while offering a compassionate view to those dealing with these health challenges. Let's get started! Request your consultation here: Contact Rukmini Rednam, MD in Houston TX and The Woodlands (drrukminirednam.com) (https://drrukminirednam.com/contact/)

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