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After just a few years on the market, a new wave of GLP-1 drugs approved for weight loss have upended what we know about obesity. By now, these are household names: Mounjaro. Wegovy. Zepbound… and yes, Ozempic. A Kaiser Family Foundation poll found that one in 8 American adults reported trying a GLP-1 medication (https://www.kff.org/health-costs/poll-finding/kff-health-tracking-poll-may-2024-the-publics-use-and-views-of-glp-1-drugs/) . “Body by Ozempic” has become a punchline on red carpets. Doctors and regulators have a strong body of evidence that GLP-1 drugs are remarkably effective at promoting weight loss and controlling diabetes. But new research looking at millions of patients in the VA medical system (https://theconversation.com/ozempic-and-similar-weight-loss-drugs-may-lower-risk-of-42-health-conditions-but-also-pose-risks-244243) has suggested they may have surprising effects on a range of other medical conditions – from cognitive diseases like Alzheimer’s to substance use disorder. The new data also found possible side effects that were not previously known.  Soundside spoke with Dr. David Cummings, professor of medicine in the Division of Metabolism, Endocrinology and Nutrition at the University of Washington, about recent data dives into the widespread use of GLP-1 medications, and what those studies tell us about how we can rethink obesity.  Guests:  • Dr. David Cummings, professor of medicine in the Division of Metabolism, Endocrinology and Nutrition at the University of Washington. Related Links:  • Sweeping review suggests weight-loss drugs’ effect on 175 conditions - The Washington Post (https://www.washingtonpost.com/health/2025/01/20/weight-loss-drugs-ozempic-wegovy-health-effects/) • End of the Line for BMI? Experts Propose New Obesity Definition - Newsweek (https://www.newsweek.com/end-bmi-experts-propose-new-obesity-definition-2015654) • Most people quit Ozempic within one year. Here's why. (https://www.usatoday.com/story/money/2025/02/02/why-people-quit-ozempic-within-one-year/78085106007/) Thank you to the supporters of KUOW, you help make this show possible! If you want to help out, go to kuow.org/donate/soundsidenotes (http://kuow.org/donate/soundsidenotes) Soundside is a production of KUOW in Seattle, a proud member of the NPR Network. See omnystudio.com/listener (https://omnystudio.com/listener) for privacy information.

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V tomto videu se dozvíte vše podstatné o obezitě jako závažném civilizačním onemocnění a o revoluční léčbě pomocí tzv. GLP-1 agonistů (např. Saxenda, Ozempic, Wegovy, Mounjaro). Co přesně je obezita, proč vzniká, jaké jsou její zdravotní dopady – a jak nám může moderní medicína pomoci? 🧬 Co je obezita a jak ji poznáme? Obezita je chronické, postupně se zhoršující metabolické onemocnění, které zásadně ovlivňuje délku i kvalitu života. Kromě BMI je důležité měřit i obvod pasu, protože vnitrobřišní tuk je rizikový pro srdce i další orgány. 📈 Proč je obezita tak rozšířená? V Česku má nadváhu téměř polovina mužů a více než třetina žen, obezitou trpí přes 20 % dospělé populace. Výskyt stále roste i u dětí! Hraje roli genetika, prostředí, špatné stravovací návyky i vliv mikrobiomu. ⚠️ Jaké jsou komplikace obezity? Zvyšuje riziko cukrovky 2. typu, vysokého tlaku, infarktu, některých nádorů, problémů s klouby, spánku i psychikou. Obezita může zkrátit život až o 10 let! 🩹 Jak obezitu léčit? Úprava stravování, pravidelný pohyb, změna životního stylu a psychologická podpora jsou základ. Pokud nestačí běžná opatření, přichází ke slovu moderní farmakoterapie. 💉 Co jsou GLP-1 agonisté a jak pomáhají? Léky jako Saxenda, Ozempic, Wegovy a Mounjaro napodobují hormon GLP-1 a ovlivňují centrum hladu v mozku, zpomalují vyprazdňování žaludku a zvyšují pocit sytosti. Výsledkem je snížení příjmu potravy a postupný pokles tělesné hmotnosti až o 10–20 % během několika měsíců. Některé jsou určeny i pro léčbu diabetu, jiné přímo pro léčbu obezity. ⚠️ Na co si dát pozor? Nejčastějšími vedlejšími účinky jsou trávicí obtíže (nevolnost, zvracení, průjem). Důležitá je postupná titrace dávky a úprava stravování během léčby. Nutné sledovat příjem bílkovin a vyhýbat se těžko stravitelným jídlům a alkoholu. 📝 Závěr GLP-1 agonisté představují velký pokrok v léčbě obezity, ale nejsou samospasitelné – vždy je nutné komplexní řešení zahrnující i změnu životního stylu. Vhodnost léčby vždy konzultujte s odborníkem. 👉 Pokud vás téma zaujalo, dejte like, odebírejte kanál a napište do komentářů, jaké s obezitou a hubnutím máte zkušenosti nebo co vás zajímá o nové generaci léčby! Prezentace: MUDr. Pavlína Doubravová Health Coaching: https://www.mindset.cz/aktualni-kurzy/8031-mindset-health-coaching/