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GLP-1 Receptor Agonists are a class of medications used in the management of type 2 diabetes mellitus. These drugs mimic the action of glucagon-like peptide-1 (GLP-1), an incretin hormone that plays a crucial role in glucose metabolism. Mechanism of Action Incretin Mimics**: GLP-1 receptor agonists activate the GLP-1 receptor, leading to several beneficial effects: Increased Insulin Secretion: Enhances glucose-dependent insulin secretion from the pancreas. Decreased Glucagon Secretion: Reduces glucagon levels, which lowers glucose production by the liver. Slowed Gastric Emptying: Delays gastric emptying, which helps to control postprandial blood glucose levels. Increased Satiety: Promotes a feeling of fullness, which can aid in weight loss. Common GLP-1 Receptor Agonists Liraglutide (Victoza, Saxenda) Semaglutide (Ozempic, Wegovy) Dulaglutide (Trulicity) Exenatide (Byetta, Bydureon) Lixisenatide (Adlyxin) 1. Liraglutide (Victoza) Dosage Starting Dose**: 0.6 mg subcutaneously once daily for one week. Maintenance Dose**: 1.2 mg to 1.8 mg once daily after the initial week. Administration**: Administer at any time of day, with or without food. 2. Semaglutide (Ozempic) Dosage Starting Dose**: 0.25 mg subcutaneously once weekly for four weeks. Maintenance Dose**: Increase to 0.5 mg once weekly; may be increased to 1 mg after at least four weeks based on glycemic control. Administration**: Administer at any time of day, with or without food. 3. Dulaglutide (Trulicity) Dosage Starting Dose**: 0.75 mg subcutaneously once weekly. Maintenance Dose**: 1.5 mg once weekly; may increase to 3 mg or 4.5 mg weekly if additional glycemic control is needed. Administration**: Administer at any time of day, with or without food. 4. Exenatide (Byetta) Dosage Starting Dose**: 5 mcg subcutaneously twice daily within 60 minutes before the two main meals. Maintenance Dose**: After one month, the dose may be increased to 10 mcg twice daily. Administration**: Do not inject after meals. Extended Release (Bydureon) Dosage**: 2 mg subcutaneously once weekly. Administration**: Can be administered at any time of day, with or without food. 5. Lixisenatide (Adlyxin) Dosage Starting Dose**: 10 mcg subcutaneously once daily within 60 minutes before the first meal. Maintenance Dose**: After two weeks, increase to 20 mcg once daily. Administration**: Administer within 60 minutes before a meal. Side Effects Common side effects of GLP-1 receptor agonists may include: Gastrointestinal Issues**: Nausea, vomiting, diarrhea, and constipation, especially during the initial period of treatment. Hypoglycemia**: Low risk when used alone, but may occur when combined with other antidiabetic medications. Pancreatitis**: Rare, but serious; patients should be monitored for symptoms. Injection Site Reactions**: Redness, swelling, or itching at the injection site. Contraindications Hypersensitivity**: Known allergy to GLP-1 receptor agonists or any of their components. Personal or Family History of Medullary Thyroid Carcinoma**: Contraindicated due to the risk of thyroid tumors. Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)**: Should not be used in patients with this condition. Monitoring Blood Glucose Levels**: Regular monitoring is important to assess effectiveness and prevent hypoglycemia. HbA1c Levels**: Periodic measurement to evaluate long-term glycemic control. Signs of Pancreatitis**: Patients should be educated about the symptoms of pancreatitis and advised to seek medical attention if they occur. Conclusion GLP-1 receptor agonists are effective agents for managing type 2 diabetes, offering multiple benefits, including improved glycemic control and weight loss. Their mechanisms of action, coupled with a generally favorable side effect profile, make them valuable in a comprehensive diabetes management plan. Always consult a healthcare provider for personalized dosing and management strategies.

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Lose fat, gain muscle. Known as “body recomposition”, many people believe this is impossible or reserved for a small percentage of people. But that’s not entirely true. Most people can definitely build muscle and lose fat at the same time. With the right nutrition and training plan, you can actually signal your body to use its existing fat stores as energy towards building muscle, and as a result, achieve body recomp. So, how do we do it? Well, there are 3 steps to a successful recomp, starting with nutrition.

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