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Dr. Bikman’s Metabolic Classroom lecture this week explores peptides and their effects on metabolism, fat loss, muscle growth, and overall health. Ben begins by defining peptides as short chains of amino acids that act as signaling molecules in the body. While some peptides occur naturally, others are synthetically developed for therapeutic purposes. He explains that peptides are gaining popularity in fitness, anti-aging, and metabolic health, influencing fat loss, muscle repair, insulin sensitivity, and even skin regeneration. He also introduces collagen peptides, highlighting their unexpected metabolic benefits, including their influence on GLP-1 and gut microbiome health. Ben then categorizes peptides based on their primary functions. For fat loss, peptides like CJC-1295 and Tesamorelin work by stimulating growth hormone and IGF-1, promoting fat breakdown while preserving muscle mass. Another peptide, Melanotan-2, originally known for increasing melanin, has been found to suppress appetite by affecting the melanocortin system. He also discusses peptides like Ipamorelin, which help enhance muscle recovery and growth by selectively increasing growth hormone secretion without affecting other pituitary hormones. In the anti-aging and skin health category, Thymosin Beta-4 stands out for its ability to enhance wound healing and tissue repair. Dr. Bikman also highlights the unexpected metabolic role of collagen peptides, explaining how they can increase GLP-1 levels, improve insulin sensitivity, and even activate AMPK, a crucial metabolic regulator involved in fat breakdown and cellular repair. Finally, he touches on how peptides are administered—most commonly via subcutaneous injections, though some peptides can be absorbed sublingually or applied topically. He cautions that not all peptides are created equal, warning against low-quality or counterfeit products. Ben emphasizes the need for high-quality sourcing and careful monitoring, as some peptides affect hormone levels and require medical supervision. Dr. Bikman concludes that peptides hold immense potential for metabolic health, fitness, and longevity, but should be used wisely and responsibly. Show Notes/References: For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more about becoming an Insider on our website: https://www.benbikman.com (Auto-Translate Note: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) #Peptides #MetabolicHealth #FatLoss #MuscleGrowth #CollagenPeptides #InsulinResistance #Hormones #GrowthHormone #CJC1295 #Tesamorelin #Ipamorelin #AntiAging #SkinHealth #Longevity #DrBenBikman #MetabolicScience #GLP1 #MuscleRecovery #GutHealth #PeptideTherapy Timestamps (approximate): 00:01 - Introduction: What Are Peptides & Why Do They Matter? 02:07 - How Peptides Influence Metabolism & Fat Loss 04:26 - Growth Hormone & Fat-Burning Peptides (CJC-1295, Tesamorelin) 06:44 - Melanotan-2: Appetite Suppression & Metabolic Effects 08:52 - Muscle Growth & Recovery Peptides (BPC-157, Ipamorelin) 12:25 - Peptides for Skin Health, Anti-Aging & Wound Healing 14:43 - The Unexpected Metabolic Benefits of Collagen Peptides 17:41 - How Peptides Are Administered: Injections, Sublingual, Topical 20:24 - Safety Considerations: Quality, Sourcing, & Monitoring 21:36 - The Future of Peptides in Metabolic Health & Longevity Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: BEN10) Ben’s favorite dress shirts and pants: https://toughapparel.com/?ref=40 (use BEN10 for 10% off) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd Learn more about becoming an Insider on our website: https://www.benbikman.com

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The ketogenic diet, commonly known as keto, has taken the health and wellness world by storm in recent years. This high-fat, low-carb diet has shown promising results for weight loss, improved energy levels, and overall health. However, it was not until keto products started appearing on the hit television show Shark Tank that the diet truly gained mainstream recognition. The synergy between keto and Shark Tank has led to a number of successful products and businesses that have helped to further popularize the diet.

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Keto on Shark Tank

Shark Tank is a reality TV show where entrepreneurs pitch their business ideas to a panel of wealthy investors, or “sharks”, in the hopes of securing funding and partnerships. Over the years, several keto-related products have been featured on the show, drawing attention to the benefits of the diet. One of the most well-known success stories is that of the company Nui, which offers low-carb, keto-friendly cookies. The founders of Nui appeared on Shark Tank and struck a deal with one of the sharks, leading to a surge in popularity for their products.

Another successful keto product that got its start on Shark Tank is the Keto Coffee from the company Kitu Super Coffee. This ready-to-drink coffee blend is made with MCT oil and protein, making it a convenient option for those following a ketogenic lifestyle. After a successful pitch on the show, Kitu Super Coffee received funding from the sharks and has since experienced rapid growth and success in the market.

One of the keys to the success of keto products on Shark Tank is the potential for scalability and mass appeal. The sharks are always looking for products that have the potential to reach a wide audience and generate significant revenue. The growing popularity of the ketogenic diet has made keto products increasingly attractive to investors on the show, leading to more opportunities for entrepreneurs in the space.

Benefits of Keto Products

One of the main advantages of keto products is their ability to support weight loss and fat burning. By reducing carbohydrate intake and increasing healthy fats, the body is forced to burn fat for fuel, leading to increased metabolism and weight loss. Keto products such as snacks, supplements, and meal replacements can make it easier for individuals to follow a ketogenic diet and achieve their health and fitness goals.

In addition to weight loss, keto products can also help improve energy levels and mental clarity. By stabilizing blood sugar levels and reducing inflammation, the ketogenic diet has been shown to boost cognitive function and overall energy levels. Keto-friendly snacks and beverages can provide a quick and convenient source of sustained energy without the crashes associated with high-carb foods.

Another benefit of keto products is their ability to support overall health and well-being. The ketogenic diet has been linked to a number of health benefits, including reduced inflammation, improved heart health, and better blood sugar control. Keto products that are made with high-quality ingredients and free from artificial additives can help individuals reap these benefits while enjoying delicious and satisfying food options.

The Future of Keto and Shark Tank

As the ketogenic diet continues to gain popularity and mainstream acceptance, the future looks bright for keto products on Shark Tank. Entrepreneurs who have developed innovative and high-quality keto products have a unique opportunity to showcase their offerings to a national audience and secure funding from experienced investors. The synergy between keto and Shark Tank has proven to be a winning combination, leading to the success of numerous businesses in the space.

Whether you’re a dedicated follower of the ketogenic diet or simply curious about the benefits of keto products, the collaboration between keto and Shark Tank offers a wealth of exciting opportunities and possibilities. From delicious low-carb snacks to convenient meal replacements, there has never been a better time to explore the world of keto and discover how it can transform your health and well-being.

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Stay tuned for future episodes of Shark Tank to see the latest and greatest keto products that are making waves in the health and wellness industry. With the support of the sharks and the backing of a national platform, the sky’s the limit for the future of keto on Shark Tank.

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Drs Piña and Kosiborod discuss semaglutide in obesity-related HF with and without diabetes. Both STEP HFpEF trials show similar HF benefits despite less weight loss in patients with diabetes. https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_yt -- TRANSCRIPT -- Ileana L. Piña, MD, MPH: Hello, and welcome to my blog. Today, I'm at the American College of Cardiology in Atlanta. I want to introduce and welcome Dr Kosiborod: from the Mid America Heart Institute, who has presented a very impactful paper, STEP HFpEF DM, that is in The New England Journal of Medicine right now. This is about semaglutide. A lot of patients ask me to give them that pill that makes them lose weight. I see primarily patients with heart failure (HF). So, Mikhail, congratulations on your presentation. Give us a little synopsis of what the trial is about. The STEP HFpEF Program Mikhail N. Kosiborod, MD: First of all, it is always a pleasure to be with you. Maybe a quick word about the STEP HFpEF program that included two trials: The first is STEP HFpEF, which was a trial of patients with obesity-related HF with preserved ejection fraction (HFpEF) who did not have diabetes, which we presented and published at European Society of Cardiology in August last year. The second installment of the program is the STEP HFpEF diabetes trial, which is essentially the same population of patients except they also have type 2 diabetes. I guess your question would be why we did two trials instead of just doing one trial that included patients, both with and without diabetes. I'll come back to that shortly. The crux of the hypothesis behind the program is that we all know the prevalence of HFpEF has increased dramatically in the past couple of decades. When I was a fellow in training, it was rare for me to see a patient with HF who had preserved EF. A majority of patients had HF with reduced EF. Now, the majority of people we see have HFpEF: Why did that happen? There are a lot of different reasons for the dramatic change in epidemiology. But certainly, one of them, at least in our opinion, is that the obesity epidemic has a lot to do with it. In fact, if you look at the population of patients with HFpEF in the United States, 80% of them are living with overweight or obesity. The hypothesis behind the program was that obesity is not just a comorbidity. It doesn't just happen to coexist by accident in this patient population, it may in fact be causing their HF. It may be a critical factor in the development and progression of HFpEF. In order to test our hypotheses, patients were randomly assigned to semaglutide, with the target dose of 2.4 mg once a week or matching placebo and treated for 52 weeks, or 1 year. The reason we did two separate trials is because part of that hypothesis was that if obesity is in fact the cause of HF, then certainly, weight loss would be probably not the only factor but "an important factor in the potential benefits of semaglutide in this patient population, provided that semaglutide is beneficial which of course we ultimately demonstrated. But what we knew from weight-loss trials — not HF trials but weight-loss trials of medications like semaglutide and also other anti-obesity medications like tirzepatide and others — is that people with diabetes tend to lose a lot less weight. With these medications, there's about a 40% less weight loss in people with type 2 diabetes. Lots of theoretical reasons why that could be the case. Nobody really knows for sure. We knew from the beginning that the weight loss likely was going to be different. Then, of course, there are other things that happen in people with diabetes: They have more severe HFpEF phenotype, and people with more severe disease sometimes don't respond to treatment the same way as those with less severe disease. Finally, we knew when we started the trial, which was back around 2019, 2020, that people with diabetes would be more likely to be treated with sodium-glucose cotransporter 2 (SGLT2) inhibitors. At the time, we didn't have the data for SLT2 inhibitors in HFpEF, but we knew that were going to be tested. There was, of course, an expectation that they may well be beneficial. For all of these reasons, we said, "You know what, the treatment effects may well be different between the patient population, but let's study them separately." Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_yt

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