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Semaglutide Patent Issues in Canada: A $450 Fee That Could Change Everything In this episode of The Downsized, Christopher Durham addresses the recent developments surrounding Novo Nordisk's handling of the patent for Semaglutide in Canada. Durham explains how Novo Nordisk, the pharmaceutical company behind Ozempic and Wegovy, failed to pay a $450 maintenance fee, allowing the patent on Semaglutide to lapse. This oversight could pave the way for generic versions to enter the Canadian market as early as 2026, significantly lowering prices for patients. Durham and his wife, Laraine, discuss the implications of this for those currently using GLP-1 medications globally and how this could create economic and political pressure to lower prices in other countries, including the United States. With over 150 pounds lost between them, the Durhams share their personal experiences with GLP-1 medications and emphasize the importance of accessible pricing. The episode highlights the broader impacts of this patent lapse, including the potential for a major shift in the global pharmaceutical market and the opportunity for Novo Nordisk to lead the industry in making life-saving medications more affordable. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Ozempic Prices Could Plummet! Thanks to a $450 Novo Blunder 01:58 THE PATENT LAPSE THAT STARTED IT ALL 03:56 A TIMELINE OF MISSED OPPORTUNITIES 05:56 STRATEGY OR SLIP-UP? 08:26 GENERIC MANUFACTURERS MOVE IN 11:03 WHAT HAPPENS AFTER CANADA? 12:55 A DRUG SO BIG IT MOVED A NATION 14:27 WHY THIS MATTERS 15:59 A MOMENT FOR NOVO TO LEAD

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Learn how Berberine HCl can support your fast! https://bit.ly/3cTYOII ----- ➢New Video w/ Dr. Fung: https://youtu.be/jXXGxoNFag4 Links to Dr. Fung's books! The Fasting Lane (new): https://amzn.to/3ghnn4i The Complete Guide to Fasting: https://amzn.to/2Elfd70 The Obesity Code: https://amzn.to/2Fj9P6R ➢Free Keto Primer eCourse https://courses.highintensityhealth.com/store/Yw9HmUNW ➢ New Webinar on Autophagy: http://bit.ly/2VjtFJj ➢ MCT On the Go: https://amzn.to/2UMLxIR Other Books by Dr. Fung: The Diabetes Code: https://amzn.to/2uLTzcq The Longevity Solution: https://amzn.to/2uomnF8 ➢ Read the Interview Transcript: http://bit.ly/2h0bAeL ------------------------------- TOOLS & VIDEO GEAR-------------------------------------------- Blood Keto Meter: https://amzn.to/2ERV5tj Keto Test Strips: https://amzn.to/2Hc5S3O2 Best Vlog & FB Live Stabilizer: https://amzn.to/2wcoJXZ Nice HD Camera Canon 6D Mark II https://amzn.to/2JyxrG5 Interview Cam C100 ii: https://amzn.to/2EC5NE8 Best Lens Ever: https://amzn.to/2IJ9WZC Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Dope Lens - Canon 85mm f/1.4L IS: https://amzn.to/2IFRG3h Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm --------------------------------------Key Takeaways---------------------------------- 0:00 Intro 2:17 History of Fasting: Fasting has been done since the dawn of humanity. Religions prescribe periods of fasting. Ancient Greeks did it for mental clarity. In the last 50 years there has been a strong move against fasting. 3:06 Nothing Wrong with Fasting: Dr. Fung investigated fasting and found that fasting had a great many benefits. Periodic fasting allows your body to burn off fat. Dr. Fung uses it with all of his overweight patients. Blood sugar medications need to be monitored closely once implementing fasting, or blood sugar could go too low.05:25 Hypoglycemia: If you are taking blood sugar meds, you may become hypoglycemic. 9:42 Muscle Loss and Fasting: Starvation mode and muscle loss are two of the many myths. Hypoglycemia is not a big concern unless you are taking blood sugar meds. As you fast, you will consume glycogen. 16:53 Hormones of Fasting: Fasting increases growth hormone. It increases noradrenaline. These are counter regulatory hormones, which counter the effect of insulin. Insulin lowers blood glucose. 22:04 Three Day a Week Fast: Dr. Fung does 24 hour fasts. 26:32 Anti-Aging Benefits: Skin is protein, so skin may alter with intermittent fasting. During the process of fasting, you get rid of old cells as part of renovation. 28:44 Autophagy: mTOR is a major regulator of autophagy. Protein turns off autophagy. mTOR is a nutrient sensor, sensing protein. 33:37 Salt and Fasting: One reason why Dr. Fung’s patients use bone broth during a fast is for salt intake. 35:49 Kidney Function: 37:07 Hormone Impacts: The main hormone affected by fasting is insulin. 42:17 Cortisol and Fasting: Cortisol does rise with fasting. It is part of the counter regulatory hormones. 43:14 Noradrenaline & Fasting 48:09 Calories: Calories have nothing to do with weight loss. Fasting is about changing your hormones. 49:50 Nutrient Changes in the 1950s: There was little obesity. People ate cookies, white bread and ice cream. You ate within a 10 hour window. 54:51 Bullet Proof Coffee/Fat Fasting: Many of the benefits of fasting come from reducing insulin. Pure fat has almost no insulin effect. 56:26 Ketogenic Diet: Intermittent fasting and ketogenic diet are along the same spectrum, close cousins. The ultra-low carb ketogenic diet lowers insulin. Low carb diet delivers 71% of the insulin lowering of fasting. 1:00:39 Dr. Fung’s Morning Routine: 1:03:45 Dr. Fung’s Favorite Nutrient: 1:07:54 Dr. Fung’s Elevator Pitch: We need to teach people about the therapeutic value of fasting. It has the potential to change the entire health system of the world. Most of what we do is treat diabetes, high blood pressure and all of the downstream issues. All of this can be taken care of for free. We need to spread the knowledge of how to do it.

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Ready to transform your body and lose stubborn belly fat? Join this powerful Weight Loss Challenge in Malayalam that includes easy-to-follow exercises and a realistic belly fat loss diet plan. Whether you're just starting or struggling to reduce your tummy, this video gives you the right steps to see real results in just a few days! In this video, you'll learn: Simple home workouts to target belly fat Diet tips for weight loss without starving How to stay consistent and motivated Weekly plan to kickstart your fat burn journey Watch till the end and take the first step toward your dream body! weight loss challenge malayalam belly fat loss malayalam malayalam weight loss tips belly fat workout, diet for belly fat home workout malayalam lose belly fat in a week malayalam fitness Soorya's Homely Tips weight loss #weightlosschallenge #bellyfatloss #bellyfatlossexercise #fullbodyworkout #weightlossmalayalam #exerciseathome #sooryashomelytipsandtricks #zumbawithsoorya #fatburning #weightlossdiet #dietforweightloss #sooryazumba

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