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Learn more at Penn Medical Group: https://pennmedicalgroup.com/ or call us at (610) 321-7777 for a free consultation. GLP-1 (glucagon-like peptide-1) agonists are a class of medications primarily developed for the treatment of type 2 diabetes. They mimic the function of the body's natural GLP-1 hormone, which is involved in glucose regulation and appetite control. Here's how GLP-1 agonists work and why they're of interest for weight loss: Stimulation of Insulin Secretion: When glucose levels rise after eating, GLP-1 stimulates the pancreas to release insulin, which helps cells absorb glucose from the bloodstream. Decrease in Glucagon Release: GLP-1 reduces the release of glucagon, a hormone that raises blood sugar levels by stimulating the liver to release stored glucose. Appetite Regulation: GLP-1 is also produced in the intestines and plays a role in signaling the brain to induce feelings of fullness or satiety. This decreases appetite and leads to reduced food intake. Gastric Emptying Delay: GLP-1 agonists can slow the rate at which the stomach empties after eating, leading to a slower rise in blood glucose and a prolonged feeling of fullness. Given these effects, especially the appetite-suppressing quality, GLP-1 agonists have been studied for their potential in weight loss, even in individuals without diabetes. Clinical studies have shown that some people taking GLP-1 agonists lost significant amounts of weight in comparison to those not on the medication. Examples of GLP-1 agonists include: - Liraglutide (brand name: Victoza for diabetes and Saxenda for weight loss) - Exenatide (brand names: Byetta, Bydureon) - Dulaglutide (brand name: Trulicity) - Semaglutide (brand name: Ozempic for diabetes and Wegovy for weight loss) It's important to consult with a healthcare professional before starting any weight loss medication. They can provide insights into potential side effects, interactions with other medications, and guidance on appropriate use.

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ONLY 12% of Americans are metabolically healthy…? In this episode, Dr. Josh Axe uncovers 7 surprising truths about metabolic health and how to reset yours naturally. From gut health to blood sugar, or sleep: this is everything you didn’t know you needed to know about mitochondrial function. You’ll learn: * Why 88% of Americans have poor metabolic health * The hidden metabolic risks for “skinny” people * How processed food, stress, and toxins wreck your energy * The top foods, habits, and supplements to boost your metabolism #rfkjr #metabolism #eatinghealthy #holistichealth #drjoshaxe ------------------- 0:00 Intro 2:07 Metabolic syndrome 2:56 Type II diabetes 4:03 Obesity 5:04 NAFLD 7:36 Dyslipidemia 9:10 High blood pressure 9:39 PCOS 10:44 Gout, type I diabetes, & mitochondrial dysfunction 12:46 Biggest causes of metabolic dysfunction 14:09 Daily diet for healing metabolic dysfunction 16:45 Chronic stress and poor sleep = cortisol 18:28 Lack of movement 20:18 Preserve Gold Ad 21:20 Toxin exposure 23:13 Hormone imbalances 28:12 Double your protein intake 29:58 Aging doesn't mean your metabolism drops 32:05 Bloodwork Ad 32:56 Metabolism is a multi-organ symphony 34:50 Your mitochondria is responsible for your metabolism 36:47 Being skinny doesn't mean you have a good metabolism! 37:55 Your gut microbiome helps control your metabolism 39:56 CGM's aren't as accurate as we think 42:30 Fix cortisol and insulin ------------------- Links: https://pubmed.ncbi.nlm.nih.gov/30484738/ https://www.unc.edu/posts/2018/11/28/only-12-percent-of-american-adults-are-metabolically-healthy-carolina-study-finds/ https://www.cdc.gov/obesity/adult-obesity-facts/index.html https://bmjopen.bmj.com/content/6/3/e009892 https://pubmed.ncbi.nlm.nih.gov/30238324/ https://pubmed.ncbi.nlm.nih.gov/31105044/ https://www.nhlbi.nih.gov/health/overweight-and-obesity/causes https://www.researchgate.net/publication/7345113_Chronic_stress_at_work_and_the_metabolic_syndrome_Prospective_study https://www.cdc.gov/physical-activity/php/about/index.html https://dph.sc.gov/diseases-conditions/conditions/diabetes/insulin-resistance-prediabetes https://www.cdc.gov/tobacco/campaign/tips/diseases/diabetes.html https://www.sciencedirect.com/science/article/pii/S0002916522035006 https://www.researchgate.net/publication/51638384_Comfort_food_is_comforting_to_those_most_stressed_Evidence_of_the_chronic_stress_response_network_in_high_stress_women https://www.rockefeller.edu/news/37433-researchers-discover-a-cause-of-leptin-resistance-and-how-to-reverse-it/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5828430/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7539343/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8370708/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2804956/ https://royalsocietypublishing.org/doi/10.1098/rsob.210333 https://pmc.ncbi.nlm.nih.gov/articles/PMC4566449/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4566449/ https://pubmed.ncbi.nlm.nih.gov/31674658/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11187407/ https://www.cdc.gov/pcd/issues/2020/20_0020.htm https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/nyas.12030 https://pmc.ncbi.nlm.nih.gov/articles/PMC9520362/ https://pubmed.ncbi.nlm.nih.gov/37236549/ https://www.npr.org/2025/06/09/nx-s1-5418465/blood-sugar-glucose-monitor-metabolic-health https://www.businessinsider.com/continuous-glucose-monitors-blood-sugar-not-diabetic-study-cgm-2025-2 ------------------- Ads: * Get your free wealth protection guide from Preserve Gold. Visit www.preservegold.com/axe or text AXE to 50505 to claim your free guide, and you could receive up to $15,000 in free gold or silver with a qualified purchase or account rollover. Don’t wait – claim your special offers today! * Get advanced lab testing for key markers like hormones, thyroid, and metabolism—plus a personalized 1-hour consultation with a Senior Health Advisor. Limited spots available at: MyBloodwork.com MB01EPAC9UCLPVH ------------------- ➕ CONNECT WITH DR. JOSH AXE Facebook → https://www.facebook.com/DrJoshAxe/ Instagram → https://www.instagram.com/drjoshaxe/ X → https://x.com/drjoshaxe/ TikTok → https://www.tiktok.com/@thedrjoshaxeshow/ Website → https://thehealthinstitute.com/ ------------------- DISCLAIMER This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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What You Need to Track When Using Weight Loss Medications If you're using GLP-1 drugs, appetite suppressants, or fat absorption blockers, it’s essential to monitor your health. These medications can impact your heart, kidneys, liver, muscle mass, and metabolic function—so tracking the right health metrics is key to staying safe and maximizing results. In this video, a PartnerMD physician explains: ✔️ Why monitoring heart rate, blood pressure, and EKGs is critical ✔️ How weight loss medications can impact kidney & liver function ✔️ The importance of tracking muscle loss vs. fat loss ✔️ Why waist circumference and body composition matter more than BMI ✔️ How weight loss medications affect insulin resistance & metabolic health 📌 Watch now to learn how to safely use weight loss medications! Timestamps 0:00 – Why Monitor these Metrics? 0:14 – What to Track When Taking Appetite Suppressants 1:05 – How Fat Absorption Blockers Affect Nutrient Levels 1:16 – GLP-1 Medications & the Risk of Muscle Loss 1:31 – Body Composition Testing: What to Measure & Why 2:06 – Why Visceral Fat Is More Important Than BMI 2:50 – How GLP-1 Medications Impact Insulin Resistance & Metabolism At PartnerMD, we provide personalized concierge medicine and executive health programs to help our patients achieve proactive, long-term wellness. Our members enjoy longer appointments, 24/7 access to physicians, advanced screenings, and a preventive approach to healthcare. ✔️ Learn more about how a concierge doctor can help your health and wellness: https://www.partnermd.com/ 🎥 More Weight Loss Medication Videos: https://www.youtube.com/playlist?list=PLrMoG9MsgOoylWi7zGnQLEWo-_9n_PAgx 📝 Related Blog Posts - "The Ozempic Era: What Are Weight Loss Medications? Could They Be Right For You?" https://www.partnermd.com/blog/what-are-weight-loss-medications Connect with PartnerMD on Social Media: Facebook https://www.facebook.com/PartnerMD/ This video is for educational purposes only and is not intended as medical advice. Always consult with your healthcare professional before making any changes to your healthcare plan. #weightloss #glp1medication #weightlosssupplements #metabolichealth #partnermd

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What’s the fastest way to get to 10% body fat — without losing muscle or crashing your energy? In this video, I break down the exact strategy I used to get shredded without starving myself, doing hours of cardio, or cutting out carbs. ✅ You’ll learn: Why traditional “eat less, move more” diets backfire The smarter, muscle-preserving protocol to get lean fast The 3 most important levers to adjust as you get leaner The science behind slow vs fast fat loss (with studies!) My full transformation — calories, macros, training, supplements The mindset shift that helped me stay consistent and enjoy the process 📚 Citations used in this video: Helms et al. (2014) – Natural bodybuilding fat loss: https://doi.org/10.1123/ijspp.2013-0311 Astrup et al. (2004) – Rapid vs slow weight loss: https://doi.org/10.1038/sj.ijo.0802788 👉 Whether you're starting at 20% or trying to dial down from 14%, this video will give you the strategy and science to get lean the right way — and keep it. ⚠️ No crash diets. No muscle loss. Just real results. 💥 Don’t forget to like, comment, and subscribe if this helped you!

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