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As a mild mitochondrial poison, metformin carries a variety of downsides. Taking it may have about a 1-in-67,000 chance of killing you every year. This is the fourth video in a five-part series. If you missed any so far, see: • Naturally Boosting AMPK with Caloric Restriction for Life Extension (https://nutritionfacts.org/video/naturally-boosting-ampk-with-caloric-restriction-for-life-extension) • Naturally Boosting AMPK with Exercise for Life Extension (https://nutritionfacts.org/video/naturally-boosting-ampk-with-exercise-for-life-extension) • Does Metformin Work as a Life-Extension Drug? (https://nutritionfacts.org/video/does-metformin-work-as-a-life-extension-drug ) And stay tuned for The TAME Trial: Targeting Aging with Metformin (https://nutritionfacts.org/video/the-tame-trial-targeting-aging-with-metformin). AMPK is one of the anti-aging pathways I highlight in my longevity book, How Not to Age (https://nutritionfacts.org/book/how-not-to-age/), available in print, e-book, and audio. (All proceeds I receive from the book are donated directly to charity.) New subscribers to our e-newsletter always receive a free gift. Get yours here: https://nutritionfacts.org/subscribe/. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/side-effects-of-metformin-as-a-life-extension-drug and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at https://nutritionfacts.org/video/side-effects-of-metformin-as-a-life-extension-drug. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources: https://nutritionfacts.org/translations-info/ https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Books: https://nutritionfacts.org/books • Shop: https://drgreger.org • Facebook: https://www.facebook.com/NutritionFacts.org • Twitter: https://twitter.com/nutrition_facts • Instagram: https://www.instagram.com/nutrition_facts_org

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