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Counseling patients, especially on their first fill, can help open up communication and put patients at ease, Jennifer L. Costello, PharmD, BCPS, BC-ADM, ambulatory care clinical pharmacist at Saint Barnabas Medical Center, explains. Letting patients know that they may experience side effects such as gastrointestinal distress may help them stay adherent.

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Cutting without Counting: http://www.thinkeatlift.com/cut/ Sigma Nutrition Radio: http://sigmanutrition.com/episode65/ Link to the article: http://www.thinkeatlift.com/reffeds-help-you-lose-fat-faster/ ‎ Tags for search engines (ignore): As we lose weight, our bodies begin to adapt to the shortage of food. The metabolic rate drops a little, hunger increases, energy levels drop a little, and so do testosterone and other hormones. These adaptations are normal and are there to increase our chances of survival because our bodies don’t know we’re intentionally losing weight. Now, refeeding is a planned increase of calorie and carbohydrate intake during a diet. It's main purpose is to reset some of the negative metabolic adaptations by acutely raising leptin levels. Leptin is a hormone which regulates hunger, metabolic rate, libido, and a lot of other functions in the body. Here's why leptin is important: Studies have shown that leptin injections speed up the metabolic rate. So the logic behind refeeding is to acutely spike leptin levels by eating more carbs. In theory that will lead to an increase in metabolic rate for a few days and prevent metabolic slowdown. But there is a problem. Spiking leptin through injections is not the same as spiking it by eating more food. Leptin injections raise leptin levels to supraphysiological levels. Also they allow you to reset a lot of the metabolic adaptation without consuming more calories, meaning you stay in a calorie deficit. But in the case of a reffed day, to spike leptin levels and speed up your metabolic rate you have to overeat - basically eliminating the calorie deficit. The amount of food you have to eat is the main problem. Studies show that a full on binge increases the metabolic rate by 3-10% for about a day. Burning 50-200 calories more in a day sounds awesome but think of the food you have to eat to achieve that effect. You will no longer be in a calorie deficit. That makes sense from an evolutionary point of view. Our metabolic rate slows down to prevent starving to death. Would it be a wise decision to reverse all the metabolic adaptation just because you had access to food for one day or a few hours? Our body doesn't think so. The story is different with longer refeeds lasting 3 days or more. When you eat at maintenance or slightly above for a few days that will most likely reverse some of the fat loss adaptation but again, not to the pre-diet levels. Remember that the amount of calories we need for maintenance is very closely linked to our body weight. A smaller body burns less energy both at rest and during any kind of activity. So there are two ways to minimize metabolic slowdown using refeeds: have refeeds that last a few days or shorter refeeds more often. There is a price though. If you do that, your weekly caloric deficit will be small and your cut will take a long time - probably 4-5 months to drop 15 pounds. Or you could go very, very low in calories on the days that you are dieting so you average a better calorie deficit. But I wouldn't recommend that. You'll probably become obsessed with food and your fitness will take over your life completely. What I recommend is that you accept the fact that your metabolic rate will go down a little while cutting no matter what you do. And you don't need to get stressed about it - studies show that the metabolic rate doesn't slow down more than 15% than what would be predicted even in the case where you lose half of your body weight like in the Minnesota Starvation Experiment. If you lose only 10-20 lbs of fat your metabolism will slow down but probably only about 100-200 calories a day depending on the person. That's not so bad.

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With millions of people now taking GLP-1 agonists like Ozempic and Wegovy, I was curious to learn if there are known genetic mutations that predispose people to have serious side effects from these medications. So exploring the pharmacogenomic aspects of Ozempic and Wegovy. To answer these questions Dr. Josiah Allen is joining the show. Josiah Allen, PharmD, has spent over 15 years in the field of pharmacogenomics, beginning at the Mayo Clinic where he helped develop the GeneSight test. As a founding employee and the first medical science liaison at Assurex Health, he helped GeneSight become one of the fastest growing molecular diagnostic tests in history. He later served as director of medical affairs at OneOme and now works at St. Elizabeth Healthcare in Edgewood, KY, as a precision medicine pharmacist and PGY2 Clinical Pharmacogenomics pharmacy residency program director. He earned his bachelor's degree in psychology from Wheaton College and his Doctor of Pharmacy degree from the University of Minnesota. Topics Covered: The basics of pharmacogenomics and its role in personalized medicine. How genetic mutations, like those in the RET gene, influence medication risks. The pharmacogenomics of GLP-1 agonists (like Ozempic and Wegovy), including their contraindications for patients with RET mutations. Insights into the overlap between ACMG secondary findings and pharmacogenomic implications. Case studies illustrating the real-world impact of pharmacogenomics. Key Takeaways: GLP-1 agonists, such as Ozempic and Wegovy, carry a black box warning due to an association with thyroid cancer, particularly in individuals with RET gene mutations. Over one-third of the ACMG secondary findings genes have pharmacogenomic implications, emphasizing the need for clinicians to integrate genetic insights into prescribing practices. Pharmacists and geneticists need closer collaboration to bridge the gap between clinical genomics and pharmacogenomics for safer medication use. Get ready, genetic nerds—another brand-new episode of DNA Today drops next Friday! You can always count on us to deliver fresh content every Friday. While you wait, why not dive into our library of over 300 episodes? Binge them all on Apple Podcasts, Spotify, our website, or wherever you love to listen—just search “DNA Today.” DNA Today is hosted and produced by Kira Dineen, MS, LCGC, CG(ASCP)CM . Our Video Lead is Amanda Andreoli. Our Social Media Lead is Kajal Patel. Our Outreach Intern is Liv Davidson. And our logo Graphic Designer is Ashlyn Enokian, MS, CGC. See what else we are up to on Instagram, X (Twitter), BluSky, Threads, LinkedIn, Facebook, YouTube all at DNATodayPodcast. Our website is DNAToday.com. Questions/inquiries can be sent to [email protected].

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We’re back with Episode 9 of Ginger and the Giant. In this one, we’re talking about how bodybuilders actually manage their weight, GLP-1 meds, cutting without losing your mind, and the classic fats vs carbs debate. We get into what’s worked for us (and what hasn’t), how we think about diet, weight training for staying healthy long-term, and some honest thoughts on the supplement industry. It’s the usual unfiltered chat. If you want real talk on bodybuilding nutrition, weight cuts, training for longevity, GLP-1s in the sport, you’ll like this one. 0:00 INTRO 6:01 GLP-1 meds for weight cuts 12:01 Fats vs carbs debate 17:57 Blood sugar management 27:32 Balancing nutrition for bodybuilding 33:27 Weight training for longevity 41:24 Supplement industry talk 48:56 Communication and being blunt 54:14 Favorite fruits 1:00:00 Worst fruits 1:06:00 Closing thoughts & plans Join the convo and drop your thoughts below we love hearing from you guys!Weightloss Trial Hits A Snag Weight Gain

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Frank Melidona, DO of The Villages Health®, explains how weight loss is about 20% exercise and 80% nutrition. This video is just one of many that offers health and wellness tips at http://bit.ly/2j1jiqn "When you’re trying to lose weight, pay attention to your nutrition more than your exercise level. Weight loss is only about 20% exercise; the other 80% is nutrition. You can’t out-run or out-exercise your fork. "There are two different types of exercise levels: NEAT (Non-Exercise Activity Thermogenesis) and EAT (Exercise Activity Thermogenesis). NEAT is the voluntary and unconscious stuff that you can do that’s not really exercise but helps your body burn calories. You can add a little bit of activity, like standing, which burns more calories than sitting. So, if you have a desk job consider doing some of your work standing. "How about strolling? When you get to Publix, try parking farther away from the front door so you’re adding a little bit of exercise. "The worst modern invention that ever came about was the remote control. Remember getting up from your chair to change the TV? We don’t do that anymore; we just point and click. Then there's the dishwasher: you'll burn more calories standing at the sink and washing dishes rather than throwing them in the dishwasher. "Doing these little things on a daily basis, you would burn about 200 extra calories without even thinking about it. That’s going to come into play when you’re starting to lose weight." Learn more about weight management: http://bit.ly/2iBYKFu Disclaimer: This content is for entertainment purposes only and it is not meant to be relied on as medical advice, diagnosis, or treatment. Consult your physician before starting any exercise or dietary program or taking any other action respecting your health. In case of a medical emergency, call 911. Subscribe to the Evergreen Wellness channel now: https://www.youtube.com/c/MyEvergreenWellness?sub_confirmation=1 Socialize with us. It’s good for you! https://www.facebook.com/MyEvergreenWellness/ https://twitter.com/evergreentoday https://www.linkedin.com/company/evergreen-wellness/ https://www.pinterest.com/evergreenwellne/ https://www.instagram.com/evergreenwellness/ https://plus.google.com/+Myevergreenwellness