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Low testosterone is sabotaging your health, motivation, and long-term vitality—and diet alone won’t fix it. In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to break through the testosterone misinformation that’s kept millions suffering. They unpack the real causes of the global testosterone crisis—including endocrine disruptors, poor sleep, processed food, and outdated fears around steroids and toxic masculinity. You’ll learn why testosterone matters for both men and women, how it powers dopamine, mitochondrial health, sleep, libido, and mood—and why “natural” testosterone boost methods usually fail. Dave and Shalin reveal how biohacking hormone health is evolving, and how new oral testosterone therapy (Kyzatrex®) is rewriting the rules with safer, more effective delivery—no injections, creams, or risky side effects. What You Will Learn in This Episode: • Why testosterone matters for men and women at every age • The real causes of the global testosterone crash • How testosterone misinformation and steroid stigma block effective treatment • Why diet, sleep, and exercise cannot fully fix low testosterone • Low testosterone symptoms most people ignore • How testosterone drives dopamine, motivation, sleep, and mitochondrial health • The breakthrough that makes oral testosterone safe and effective • How Kyzatrex® lowers SHBG and boosts free testosterone naturally • Why restoring testosterone is key to libido, brain health, and longevity • How to use testosterone therapy safely—without suppressing fertility ** Visit livethrive.co/asprey to get a discount on your first month's supply! ** Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey • Shalin’s Instagram - https://www.instagram.com/themetabolicceo/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: 00:00 Trailer 00:52 Introduction 01:29 Global Decline in Testosterone Levels 02:27 Symptoms of Low Testosterone 03:48 Personal Journey with Testosterone Therapy 05:06 The Role of Testosterone in Overall Health 06:18 Testosterone Levels in Men and Women 08:48 Challenges and Innovations in Testosterone Delivery 16:25 The Importance of Circadian Rhythm in Testosterone Therapy 19:19 The Future of Testosterone Therapy 32:00 Investment and Development in Testosterone Therapy 34:57 Introduction to FDA and Hormone Replacement 35:31 FDA’s Impact on Women’s Health 36:10 Testosterone and Cardiovascular Risk 39:05 Testosterone and Depression 40:30 Testosterone Testing and Misconceptions 44:58 The Testosterone Project and Female Hormone Therapy 47:51 Testosterone’s Role in Longevity and Health 55:37 Cost and Accessibility of Testosterone Therapy 01:04:03 Conclusion and Final Thoughts Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/
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In recent years, there has been a lot of buzz surrounding semaglutide as a potential weight loss medication. This drug, originally approved for type 2 diabetes, has shown promising results in clinical trials for its ability to help patients lose weight. But what exactly is semaglutide, and how does it work? If you’re considering using this medication for weight loss, here’s what you need to know.
What is Semaglutide?
Semaglutide is a medication that belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. Originally developed for the treatment of type 2 diabetes, semaglutide has been found to have additional benefits for weight loss.
When used for weight loss, semaglutide is typically administered via injection once a week. The drug works by mimicking the effects of a hormone called GLP-1, which helps regulate blood sugar levels and appetite.
Studies have shown that semaglutide can help people lose a significant amount of weight when used in conjunction with diet and exercise. In fact, some clinical trials have demonstrated that patients who took semaglutide lost up to 15% of their body weight.
Potential Side Effects
Like any medication, semaglutide does come with potential side effects. Some of the most common side effects reported by patients taking semaglutide for weight loss include nausea, vomiting, diarrhea, and constipation.
In rare cases, semaglutide has been associated with more serious side effects such as pancreatitis and thyroid tumors. It’s important to discuss the potential risks and benefits of taking semaglutide with your healthcare provider before starting treatment.
Additionally, some patients may experience allergic reactions to semaglutide, including rash, itching, and difficulty breathing. If you experience any of these symptoms after taking semaglutide, seek medical attention immediately.
Who Can Benefit from Semaglutide?
Semaglutide is generally recommended for individuals who have a body mass index (BMI) of 27 or higher and have at least one weight-related health condition, such as hypertension or type 2 diabetes. However, it’s important to note that semaglutide is not a magic pill for weight loss.
For the best results, semaglutide should be used in conjunction with a healthy diet and regular exercise. It’s also important to work closely with your healthcare provider to monitor your progress and adjust your treatment plan as needed.
Overall, semaglutide can be an effective tool for weight loss for the right candidates. If you’re considering using this medication, talk to your healthcare provider to see if it may be a good option for you.
Cost and Availability
One of the potential barriers to using semaglutide for weight loss is the cost. This medication can be expensive, especially for individuals who are not covered by insurance. However, some pharmaceutical companies offer financial assistance programs to help offset the cost of semaglutide for eligible patients.
In terms of availability, semaglutide is currently only available by prescription. Your healthcare provider can determine if semaglutide is a suitable option for you based on your individual health needs and goals.
Before starting treatment with semaglutide, be sure to discuss any concerns or questions with your healthcare provider. They can provide you with more information about how this medication works and whether it may be a good fit for your weight loss journey.

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